ID A0A137PBI9_CONC2 Unreviewed; 851 AA.
AC A0A137PBI9;
DT 11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT 11-MAY-2016, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN ORFNames=CONCODRAFT_4818 {ECO:0000313|EMBL:KXN72375.1};
OS Conidiobolus coronatus (strain ATCC 28846 / CBS 209.66 / NRRL 28638)
OS (Delacroixia coronata).
OC Eukaryota; Fungi; Fungi incertae sedis; Zoopagomycota;
OC Entomophthoromycotina; Entomophthoromycetes; Entomophthorales;
OC Ancylistaceae; Conidiobolus.
OX NCBI_TaxID=796925 {ECO:0000313|EMBL:KXN72375.1, ECO:0000313|Proteomes:UP000070444};
RN [1] {ECO:0000313|EMBL:KXN72375.1, ECO:0000313|Proteomes:UP000070444}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL 28638 {ECO:0000313|EMBL:KXN72375.1,
RC ECO:0000313|Proteomes:UP000070444};
RX PubMed=25977457; DOI=10.1093/gbe/evv090;
RA Chang Y., Wang S., Sekimoto S., Aerts A.L., Choi C., Clum A., LaButti K.M.,
RA Lindquist E.A., Yee Ngan C., Ohm R.A., Salamov A.A., Grigoriev I.V.,
RA Spatafora J.W., Berbee M.L.;
RT "Phylogenomic Analyses Indicate that Early Fungi Evolved Digesting Cell
RT Walls of Algal Ancestors of Land Plants.";
RL Genome Biol. Evol. 7:1590-1601(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
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DR EMBL; KQ964454; KXN72375.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A137PBI9; -.
DR STRING; 796925.A0A137PBI9; -.
DR EnsemblFungi; KXN72375; KXN72375; CONCODRAFT_4818.
DR OMA; TIRFPMP; -.
DR OrthoDB; 57056at2759; -.
DR Proteomes; UP000070444; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR CDD; cd18795; SF2_C_Ski2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.10.3380.10; Sec63 N-terminal domain-like domain; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004179; Sec63-dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR47835; HFM1, ATP DEPENDENT DNA HELICASE HOMOLOG; 1.
DR PANTHER; PTHR47835:SF2; SEC63 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF02889; Sec63; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00973; Sec63; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF158702; Sec63 N-terminal domain-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:KXN72375.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000070444}.
FT DOMAIN 81..253
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 295..482
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 851 AA; 97166 MW; C6417F8E8FC3608F CRC64;
MRRYESNSKP NKFKPPWQKR PRASGFKSNI GYTNINSTDV PISNTQPSDY DRLLPVSVLG
TKFSKLFPYS HLNKVQSECY HSIMDSNDNI VVNAPTGSGK TGILELAMSK VFSNDQFDKC
IYLAPTRSLC YERYSDWKEK LRNLQISCVE FTGDSEMEMS EALCYHLILS TPEKWDSATR
KNFMANYEMM KKIKLIMIDE VHILNENRGA ALEALVSRMK SVFTNIRIIS VSATIPNISS
IANWISTPDK TFMKLNTTIK VFGENYRPVP LKKVVVAQRN NSRNPFIFEQ NLNHKLPELI
KGYSNSKPTL IFCTSRKAAQ TSCKFLSENI NGNSLNQFYF PSNILDKVQD SSLKSYLVHG
VGYHHAGLGL QDKHIVENAF REGRLSILFA TSTLAVGVNL PAHLVIIKST KGYFNSEYRQ
YSDLEILQMI GRAGRPQFDT SATAVILTET ETKEHYENLI NGKQFIESCL HNYLIEHLNA
EICLGSVKNM KEAIHWLKTT FLYVRIQENP TYYSFLSNVD MLLSPEKKLE ALCIKNLNLL
DKNGIINIEP INDNFISTPL SAAMSKYYLK FESILVLIEE KKNFTLSQLI ELISKTCEFR
EVRFQPGEKP GLNDLLKDPG IKFKLKKIKL ISDKINLLIQ AHIGSVNLSS VKNFNINLET
LKISSLASRL CKCLIEISKY YKLGLSLKNS VILIRCIKNR LWPEDNKLKQ LKNLGQTTSK
TLIMNEIKTF DELANTEPRK IEWILKRNPP FGNNIIETVK LLPKFFMNID RSKNGFIKAE
IGIQNSEVIE LTKDGFPHFA TLIVTTSDNQ LILHSRYTLY KLTNSIEIEI KIKNYANLNI
LIDLINESIG M
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