ID A0A137QAW1_9AGAR Unreviewed; 347 AA.
AC A0A137QAW1;
DT 11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT 11-MAY-2016, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Sterol 24-C-methyltransferase erg6 {ECO:0000313|EMBL:KXN84388.1};
GN ORFNames=AN958_12647 {ECO:0000313|EMBL:KXN84388.1};
OS Leucoagaricus sp. SymC.cos.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Agaricineae; Agaricaceae; Leucoagaricus.
OX NCBI_TaxID=1714833 {ECO:0000313|EMBL:KXN84388.1, ECO:0000313|Proteomes:UP000070249};
RN [1] {ECO:0000313|EMBL:KXN84388.1, ECO:0000313|Proteomes:UP000070249}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SymC.cos {ECO:0000313|EMBL:KXN84388.1,
RC ECO:0000313|Proteomes:UP000070249};
RA Hu H.;
RT "Leucoagaricus sp. SymC.cos WGS genome.";
RL Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. Erg6/SMT family. {ECO:0000256|ARBA:ARBA00038188,
CC ECO:0000256|PROSITE-ProRule:PRU01022}.
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DR EMBL; KQ962641; KXN84388.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A137QAW1; -.
DR STRING; 1714833.A0A137QAW1; -.
DR OrthoDB; 275921at2759; -.
DR Proteomes; UP000070249; Unassembled WGS sequence.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:1901617; P:organic hydroxy compound biosynthetic process; IEA:UniProt.
DR GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR025714; Methyltranfer_dom.
DR InterPro; IPR030384; MeTrfase_SMT.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR013705; Sterol_MeTrfase_C.
DR PANTHER; PTHR44068:SF1; HYPOTHETICAL LOC100005854; 1.
DR PANTHER; PTHR44068; ZGC:194242; 1.
DR Pfam; PF13847; Methyltransf_31; 1.
DR Pfam; PF08498; Sterol_MT_C; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51685; SAM_MT_ERG6_SMT; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|PROSITE-ProRule:PRU01022,
KW ECO:0000313|EMBL:KXN84388.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000070249};
KW S-adenosyl-L-methionine {ECO:0000256|PROSITE-ProRule:PRU01022};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU01022}.
FT DOMAIN 48..345
FT /note="SAM-dependent methyltransferase Erg6/SMT-type"
FT /evidence="ECO:0000259|PROSITE:PS51685"
SQ SEQUENCE 347 AA; 39453 MW; 21DCEEAF44DAF659 CRC64;
MTVTQTVDGR VADRIENYTK YWKEDPNAEQ SQDNEKRLDN YTDVVNGYYD GATGLYEWGW
SQSFHFSRFY KGEAFLASLA RHEHYLSCHM SLKPGMRVLD VGCGVGGPAR EIAMFSDANI
VGLNNNAFQV GRARKYTQKM GLENQVQFVQ GDFMKLSEQF GENSFDAVYA IEATVHAPTW
EGVYGEIFKV LKPGGVFGVY EWCMTDDWDP SIPEHKALAH QIELGNGIPE MRPLRLARQA
LKDVGFEIEH EEDLADRPDS VPWYYPLEGD ISKAQTFWDY LTVWRMSWSG KLVSHNAIRL
MEWVGILPKG TFDVSESLKV AADALVKGGQ TKLFTPMYLV VSRKPRN
//
