ID   A0A137QDZ6_9AGAR        Unreviewed;       799 AA.
AC   A0A137QDZ6;
DT   11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT   11-MAY-2016, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   RecName: Full=Translation initiation factor eIF2B subunit epsilon {ECO:0000256|ARBA:ARBA00044144};
DE   AltName: Full=eIF2B GDP-GTP exchange factor subunit epsilon {ECO:0000256|ARBA:ARBA00044345};
GN   ORFNames=AN958_11276 {ECO:0000313|EMBL:KXN85472.1};
OS   Leucoagaricus sp. SymC.cos.
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC   Agaricomycetidae; Agaricales; Agaricineae; Agaricaceae; Leucoagaricus.
OX   NCBI_TaxID=1714833 {ECO:0000313|EMBL:KXN85472.1, ECO:0000313|Proteomes:UP000070249};
RN   [1] {ECO:0000313|EMBL:KXN85472.1, ECO:0000313|Proteomes:UP000070249}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SymC.cos {ECO:0000313|EMBL:KXN85472.1,
RC   ECO:0000313|Proteomes:UP000070249};
RA   Hu H.;
RT   "Leucoagaricus sp. SymC.cos WGS genome.";
RL   Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000256|ARBA:ARBA00004514}.
CC   -!- SIMILARITY: Belongs to the eIF-2B gamma/epsilon subunits family.
CC       {ECO:0000256|ARBA:ARBA00007878}.
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DR   EMBL; KQ962466; KXN85472.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A137QDZ6; -.
DR   STRING; 1714833.A0A137QDZ6; -.
DR   OrthoDB; 5474157at2759; -.
DR   Proteomes; UP000070249; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0031369; F:translation initiation factor binding; IEA:InterPro.
DR   CDD; cd04197; eIF-2B_epsilon_N; 1.
DR   CDD; cd11558; W2_eIF2B_epsilon; 1.
DR   Gene3D; 1.25.40.180; -; 1.
DR   Gene3D; 2.160.10.10; Hexapeptide repeat proteins; 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR035543; eIF-2B_epsilon_N.
DR   InterPro; IPR005835; NTP_transferase_dom.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   InterPro; IPR011004; Trimer_LpxA-like_sf.
DR   InterPro; IPR003307; W2_domain.
DR   InterPro; IPR044123; W2_eIF2B_epsilon.
DR   PANTHER; PTHR45887; TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON; 1.
DR   PANTHER; PTHR45887:SF1; TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON; 1.
DR   Pfam; PF00483; NTP_transferase; 1.
DR   Pfam; PF02020; W2; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
DR   SUPFAM; SSF51161; Trimeric LpxA-like enzymes; 1.
DR   PROSITE; PS51363; W2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Initiation factor {ECO:0000313|EMBL:KXN85472.1};
KW   Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW   Reference proteome {ECO:0000313|Proteomes:UP000070249}.
FT   DOMAIN          573..748
FT                   /note="W2"
FT                   /evidence="ECO:0000259|PROSITE:PS51363"
FT   REGION          454..575
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          739..799
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        553..569
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   799 AA;  87973 MW;  86A9A64A114604F1 CRC64;
     MASQTNTKEK LIDDEEVLQA VVLADSFNKR FRPLTARKPR CLLPICNAPL LDWTFESLAL
     AGVQEVFVIC RSHADQVKEA IKESKWSKPG SGMKICPIMT SRETYSPGDA MRDIYTRGLV
     TTDFVLVTGD LVSNIRIDEV VRVHKERRKT NKDAIMTMVV KASGAQHRTR ARGESSIFVV
     DPATSECLHY ESITGFPSTK VAKMPREILA EHSEVEIRND LIDCSIDVCV VTLLTALPTA
     LTCPKVPSLF QDNFDYGDIR RDFVHGVLTS DLLMKSIHLY VAQEGYAARV QDTRSYESIR
     QVLARSPKDI LSRWTFPLVP DDNHPSGHNY ELRRGNRYIA KDGTVVLARS CKIGPNTLIG
     PSTKISEDTE IISSVIGQNC TIGAGTIIDN SYIFDNTVIG PNCKIQRSIV GSGCSIGENT
     HILNGSLIGD GVIIGPDVSL SPFERLSVQR LSVTRAPTTD DSGEEDSDLE AVEGDQGSIK
     GNLNLGKNSN ALVWPRGPPD EEEDTEDVEN YKNQRFMRLG DNASDILSSD SGSETSENEE
     SSSEDDLDSQ YDGRSVSALS DTSAPSDIHT FPDTAEKEFR TEVKQSLDRA FAEGHSVDNA
     AVELKTLRMA SNVSLTRVRE AVIAAIVERI PLIDSGTIQQ RKEIATVIDR WGALIDKIGG
     VDAVETVCLL QAHCATSARM PLFGQILAAL YQDDIADEDD IRKWHDLLAS KGDERKPSPE
     TDNFKKCWLI GSHMIKQFDD QGSEEEDDDV ESSPVPANES TPVGESEDEE DDRHAVPSSA
     SASQRRMSRQ SEGESDEEE
//