ID   A0A137QG61_9AGAR        Unreviewed;       917 AA.
AC   A0A137QG61;
DT   11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT   11-MAY-2016, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   SubName: Full=Putative Xaa-Pro aminopeptidase P {ECO:0000313|EMBL:KXN86245.1};
GN   ORFNames=AN958_10323 {ECO:0000313|EMBL:KXN86245.1};
OS   Leucoagaricus sp. SymC.cos.
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC   Agaricomycetidae; Agaricales; Agaricineae; Agaricaceae; Leucoagaricus.
OX   NCBI_TaxID=1714833 {ECO:0000313|EMBL:KXN86245.1, ECO:0000313|Proteomes:UP000070249};
RN   [1] {ECO:0000313|EMBL:KXN86245.1, ECO:0000313|Proteomes:UP000070249}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SymC.cos {ECO:0000313|EMBL:KXN86245.1,
RC   ECO:0000313|Proteomes:UP000070249};
RA   Hu H.;
RT   "Leucoagaricus sp. SymC.cos WGS genome.";
RL   Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|ARBA:ARBA00001936};
CC   -!- SIMILARITY: Belongs to the peptidase M24B family.
CC       {ECO:0000256|ARBA:ARBA00008766}.
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DR   EMBL; KQ962373; KXN86245.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A137QG61; -.
DR   STRING; 1714833.A0A137QG61; -.
DR   OrthoDB; 869at2759; -.
DR   Proteomes; UP000070249; Unassembled WGS sequence.
DR   GO; GO:0070006; F:metalloaminopeptidase activity; IEA:InterPro.
DR   CDD; cd01085; APP; 1.
DR   Gene3D; 3.90.230.10; Creatinase/methionine aminopeptidase superfamily; 1.
DR   Gene3D; 3.40.350.10; Creatinase/prolidase N-terminal domain; 2.
DR   InterPro; IPR029149; Creatin/AminoP/Spt16_NTD.
DR   InterPro; IPR036005; Creatinase/aminopeptidase-like.
DR   InterPro; IPR000587; Creatinase_N.
DR   InterPro; IPR000994; Pept_M24.
DR   InterPro; IPR033740; Pept_M24B.
DR   InterPro; IPR032416; Peptidase_M24_C.
DR   PANTHER; PTHR43763; XAA-PRO AMINOPEPTIDASE 1; 1.
DR   PANTHER; PTHR43763:SF6; XAA-PRO AMINOPEPTIDASE 1; 1.
DR   Pfam; PF01321; Creatinase_N; 1.
DR   Pfam; PF16189; Creatinase_N_2; 1.
DR   Pfam; PF00557; Peptidase_M24; 1.
DR   Pfam; PF16188; Peptidase_M24_C; 1.
DR   SUPFAM; SSF55920; Creatinase/aminopeptidase; 1.
DR   SUPFAM; SSF53092; Creatinase/prolidase N-terminal domain; 1.
PE   3: Inferred from homology;
KW   Aminopeptidase {ECO:0000313|EMBL:KXN86245.1};
KW   Hydrolase {ECO:0000313|EMBL:KXN86245.1};
KW   Protease {ECO:0000313|EMBL:KXN86245.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000070249}.
FT   DOMAIN          291..422
FT                   /note="Creatinase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF01321"
FT   DOMAIN          616..828
FT                   /note="Peptidase M24"
FT                   /evidence="ECO:0000259|Pfam:PF00557"
FT   DOMAIN          841..899
FT                   /note="Peptidase M24 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF16188"
FT   REGION          22..265
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        25..71
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        112..128
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        136..157
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        172..190
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        191..209
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        213..235
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        236..265
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   917 AA;  102844 MW;  C5FCDBFA73C4B579 CRC64;
     MPPPPPPPIC FPFISKKQKR RLSIGAASEI SSGQHLGGSG HARTASATHL SRHHSYSSSS
     TLTSVPDNLT FRTDSEKYDE VPPLLTGTGS GQHSPRGGSD KMKGFLTNPV SLKRGNAITG
     TKKSTASSKW GGYGWGLGKK EKEVEAELMR ERDRESTSSP LPLYQPERTP SSESKKGVDG
     YKDRELMSPI RHNSKSSQGS RSTAATLHSH DLHYSEGLLE RRDTVKSRDT ARTKDSKFTQ
     GTSSSRSSAP RPRPPLTASD STSTLVGSAL ERKIQGDVES IPDKSVSTTE RLADLRAEME
     KAGVDYYIVP SEDAHGSEYV AASDKRREFI TGFTGSKGDA IITRESAYLV TDPRYWTQAE
     NQTDRNWTIV KAGVVHDISQ KVYRDWVEFF LTLLSKGQKI GIDARMIAHE KAAMINSKLT
     NLDCKFVFPS QNLIDLVWKE KPGKPRGVVY VQSIEYTGKD ASYKLYKLKE WIKAHPPSIP
     SFSKNTEPTP QQMHVGMLVT SLACIAWALN LRGVDIPFNP LFHAYLYIGL DKTILFLDSS
     KVDDAVTSYL EKMNVERRNY TDLWSFLRRR EWGEGKLLIP PSTSYAISLM LTHFRYTLAP
     NRVEYMMALK NETELEGLRK AYIRDGVAFV QFLAWLDNKL NSGYDITEWE AAWRIKEFRM
     KQRKFMGLAY ETVSASGPNG AIPHYAPKKH SARMIDRDTP YLNDSGGQYR DGTCDTTRTV
     HFGRPTPDQS EAYTRVLQGH IAIDSAVFPE GTSGYQLDVL ARKALWKDGL NYMHGTGHGF
     GSFLTVHEGD HGFNSSAPLM PGHVITNEPG FYIKNKWGVR IESALIVRRV QTKHEFNGNI
     WLGFERITCV PIQTRMVKES MLTKEEKSWL KEHNQKCWDV LSPYLKDDKV ALKWLKREAD
     RGIGIASGPA GMAIDWD
//