ID A0A137QQM0_9AGAR Unreviewed; 1699 AA.
AC A0A137QQM0;
DT 11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT 11-MAY-2016, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE RecName: Full=DNA-directed RNA polymerase subunit {ECO:0000256|RuleBase:RU004279};
DE EC=2.7.7.6 {ECO:0000256|RuleBase:RU004279};
GN ORFNames=AN958_05429 {ECO:0000313|EMBL:KXN89562.1};
OS Leucoagaricus sp. SymC.cos.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Agaricineae; Agaricaceae; Leucoagaricus.
OX NCBI_TaxID=1714833 {ECO:0000313|EMBL:KXN89562.1, ECO:0000313|Proteomes:UP000070249};
RN [1] {ECO:0000313|EMBL:KXN89562.1, ECO:0000313|Proteomes:UP000070249}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SymC.cos {ECO:0000313|EMBL:KXN89562.1,
RC ECO:0000313|Proteomes:UP000070249};
RA Hu H.;
RT "Leucoagaricus sp. SymC.cos WGS genome.";
RL Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC {ECO:0000256|RuleBase:RU004279}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.6; Evidence={ECO:0000256|ARBA:ARBA00024550,
CC ECO:0000256|RuleBase:RU004279};
CC -!- SIMILARITY: Belongs to the RNA polymerase beta' chain family.
CC {ECO:0000256|RuleBase:RU004279}.
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DR EMBL; KQ962079; KXN89562.1; -; Genomic_DNA.
DR STRING; 1714833.A0A137QQM0; -.
DR OrthoDB; 169836at2759; -.
DR Proteomes; UP000070249; Unassembled WGS sequence.
DR GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR CDD; cd02735; RNAP_I_Rpa1_C; 1.
DR CDD; cd01435; RNAP_I_RPA1_N; 1.
DR Gene3D; 1.10.132.30; -; 1.
DR Gene3D; 1.10.150.390; -; 1.
DR Gene3D; 1.10.357.120; -; 1.
DR Gene3D; 2.40.40.20; -; 1.
DR Gene3D; 3.30.70.2850; -; 1.
DR Gene3D; 6.10.250.2940; -; 1.
DR Gene3D; 3.30.1490.180; RNA polymerase ii; 1.
DR Gene3D; 4.10.860.120; RNA polymerase II, clamp domain; 1.
DR Gene3D; 1.10.274.100; RNA polymerase Rpb1, domain 3; 1.
DR InterPro; IPR047107; DNA-dir_RNA_pol1_lsu_C.
DR InterPro; IPR015699; DNA-dir_RNA_pol1_lsu_N.
DR InterPro; IPR045867; DNA-dir_RpoC_beta_prime.
DR InterPro; IPR000722; RNA_pol_asu.
DR InterPro; IPR006592; RNA_pol_N.
DR InterPro; IPR007080; RNA_pol_Rpb1_1.
DR InterPro; IPR007066; RNA_pol_Rpb1_3.
DR InterPro; IPR042102; RNA_pol_Rpb1_3_sf.
DR InterPro; IPR007083; RNA_pol_Rpb1_4.
DR InterPro; IPR007081; RNA_pol_Rpb1_5.
DR InterPro; IPR044893; RNA_pol_Rpb1_clamp_domain.
DR InterPro; IPR038120; Rpb1_funnel_sf.
DR PANTHER; PTHR19376; DNA-DIRECTED RNA POLYMERASE; 1.
DR PANTHER; PTHR19376:SF11; DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA1; 1.
DR Pfam; PF04997; RNA_pol_Rpb1_1; 1.
DR Pfam; PF00623; RNA_pol_Rpb1_2; 1.
DR Pfam; PF04983; RNA_pol_Rpb1_3; 1.
DR Pfam; PF05000; RNA_pol_Rpb1_4; 1.
DR Pfam; PF04998; RNA_pol_Rpb1_5; 1.
DR SMART; SM00663; RPOLA_N; 1.
DR SUPFAM; SSF64484; beta and beta-prime subunits of DNA dependent RNA-polymerase; 1.
PE 3: Inferred from homology;
KW DNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022478,
KW ECO:0000256|RuleBase:RU004279};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000256|RuleBase:RU004279}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000070249};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU004279};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU004279}.
FT DOMAIN 350..693
FT /note="RNA polymerase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00663"
FT REGION 147..168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 439..460
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1118..1138
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1372..1478
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1118..1135
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1389..1427
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1428..1452
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1457..1478
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1699 AA; 190340 MW; 554DC707A5850361 CRC64;
MNIAHSLPST VASIGFSFLT TQDVRRISVK QIVNPVLLDD LNRPNIGGLY DPALGPSDRS
DICTTCRLTY FTCPGHYGHI ELPAPVFHPL FMGNMYNLLR GCCMFCHRFK MGRTTLCKYT
AKFRLLERGL LEAAQGIDDI QLRARKRKTK ARGEDEEEEE TVDTGLPDET PQEFMTRINL
YVAIHLSRAK GNTRDDYKDG LVYQARKELI NDFLKNTLIK KCQNGDCNSV AYTYRKEGYT
KIIEYDLSPK QKASLTRKRP DVLLAEKTGN FTLLQQSKPA VDSAVDMDGS QAGEMKTARG
RNERVVAPEE CRAHLRRLFR NEAVACSLIF GRHGPFAPLS HEQLSYASAD MFFMEVIPVS
PTRFRPPAKM GETLFEHAQN ELLSRVLSTS YRMRDINVEL RALQQKKDEP IDENTRRTLL
ASLLERLVQL QVDVNSFVDS SKNPQPVRQG KLPPPGVKQG LEKKEGLFRK HMMGKRVNYA
ARSVISPDVN IEPNEIGVPP VFARKLTFPE PVTPANFHEM RQRVIIGPHG YPGASMVEYE
DGHQQSLDKL TVEQRTAIAN QLLTPQEGER AASGRKGLHT RTPAINKKVY RHLKDGDILI
LNRQPTLHKP SMMAHKAKVL KGEKTIRMHY ANCNSYNADF DGDEMNIHFP QNHVARAEAM
MIANTDNQYL VPTSGNPLRG LIQDHVVAGV WMTSQDAFFS REEYFQLLYG ALRPEDEDYC
ASGRLETLPP TIWKPKPLWT GKQIISTILK NITPPQYKGL NLNAKTKVPG FLWGKDSKED
KVVFMDGELL CGVLDKAAFG ASDYGLVHSV YELYGADIAG KFLGILSRLF TKFLQHRAFT
CRMDDLVLTP EGDHKRDELL EKGKNLGTEA AIENFPSLKN IPTSEIPVAL EALLQDVLRD
DNKMAGLDMT VKTKLSKLTS SISDACLPNG LLRKFPHNHM QTMTQSGAKG SAVNARQISC
GLGQQELEGR RVPVMISGKT LPSFRPFETK AIAGGYVASR FLTGIKPQEF YFHCMAGREG
LIDTAVKTSR SGYLQRCLIK HLEGIHVHYD HTVRGSDNSV YQFTYGGDAL DVTKQKHLCQ
FNFIAQNEES LVMRLQPGRV ADAVDNSAAL SYMKKVLKRS TEHPRRGEPS KRDKYDPALS
TYSPSRFLGA TSEQFAVAVD NYMKGNTSGL LEKKGEEEFF KRRHEKMTAY NFKMLVNVKY
MRSLVEPGEA VGLLASQGVG EPSTQMTLNT FHFAGHGAAN VTLGIPRLRE IVMTASQKPK
TPSMTMTIRK GVPQAEIDLF CKRASRVALS QLVENVIVRE TSKVEGQARR TVFSIDINFF
PQDEYTKEHD VEPSEILNVF AVRFPLTLKK EIANEMKRLD ADLKSQIAEL GKGKKVSERE
GGDGDVDEES EEAPKKRRGD DEESEVGDGD AGDEKRARQK KQQATYESDE DEDEDEPEGE
YDDAEIEAAY AEDQDTMEVG SDEKKKKKKP SSLEEEASRV ADTFTSHLHH AISFTFTPSQ
CNFELEFTTD VPKLLFVGII ERTCRASVIR EIPGITDCFQ TKDDNKKEPE IKLTTNGSNL
RGMWEFAAGS GESILEDEEI YSNDIYAILK TYGVEMARAA ILREMGGVFG AYNIQVDRRH
LELIADYMTF EGGYKPFNRK GISTSPSPLL KASYETTAAF LSDATLYGDF DDLSTPSGNI
VLGRPNATGT GVFDVVMPV
//
