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Database: UniProt
Entry: A0A138AUJ9_9ACTN
LinkDB: A0A138AUJ9_9ACTN
Original site: A0A138AUJ9_9ACTN 
ID   A0A138AUJ9_9ACTN        Unreviewed;       497 AA.
AC   A0A138AUJ9;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   25-OCT-2017, entry version 15.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=AXK60_21410 {ECO:0000313|EMBL:KXP14056.1};
OS   Tsukamurella pseudospumae.
OC   Bacteria; Actinobacteria; Corynebacteriales; Tsukamurellaceae;
OC   Tsukamurella.
OX   NCBI_TaxID=239498 {ECO:0000313|EMBL:KXP14056.1, ECO:0000313|Proteomes:UP000070258};
RN   [1] {ECO:0000313|EMBL:KXP14056.1, ECO:0000313|Proteomes:UP000070258}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCM 15929 {ECO:0000313|EMBL:KXP14056.1,
RC   ECO:0000313|Proteomes:UP000070258};
RA   Wen L., He K., Yang H.;
RL   Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00735475}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KXP14056.1}.
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DR   EMBL; LSRF01000007; KXP14056.1; -; Genomic_DNA.
DR   RefSeq; WP_068570138.1; NZ_LSRF01000007.1.
DR   EnsemblBacteria; KXP14056; KXP14056; AXK60_21410.
DR   Proteomes; UP000070258; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000070258};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895}.
FT   DOMAIN      191    319       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      403    471       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     199    206       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   497 AA;  55180 MW;  DFE1C482860441EC CRC64;
     MTVDPLIETW TAVVDELCGD NTDRTLTKQE KAWLKLVQPL TLTEGFALVA VPSQLMKDAI
     ERSLREPLVA ALTTRLGQDV ELGVRISPDA TPPVVAPAVG SPAEAPSGPS TADLAVPVTE
     ISSGMPGAPS PSVQLPPPTT GPAPSGNGTG PSGSSGSSLN QKYTFETFVI GASNRFAHAA
     AFAVAEAPAR AYNPLFIWGE SGLGKTHLLH AAGHYARRLF PGMRVKYVST EEFTNDFINS
     LKDDRQVQFK QRYRDVDILL VDDIQFLEGK LGIQEEFFHT FNTLHNANKQ IVVSSDRPPK
     QLATLEDRLR TRFEWGLITD VQPPELEIRM AILLKKAQME RIHVPPDVLE LIATRIDRNI
     RELEGALIRV TAFASLTQTD VTYELAEMVL RDLVPDTTTL EISSSTILSV VAEYFEISVA
     DLKGTERARA VTHARQIAMY LCRELTELSL PKIGQIFDRD HTTVMYAERK IRKEMPERRR
     VYDQVQELTT RIKRRSQ
//
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