ID A0A139CTH3_9FIRM Unreviewed; 545 AA.
AC A0A139CTH3;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=inorganic diphosphatase {ECO:0000256|ARBA:ARBA00012146};
DE EC=3.6.1.1 {ECO:0000256|ARBA:ARBA00012146};
DE AltName: Full=Pyrophosphate phospho-hydrolase {ECO:0000256|ARBA:ARBA00032535};
GN ORFNames=AWU54_749 {ECO:0000313|EMBL:KXS44479.1};
OS Candidatus Frackibacter sp. T328-2.
OC Bacteria; Bacillota; Clostridia; Halanaerobiales; Halobacteroidaceae;
OC Frackibacter.
OX NCBI_TaxID=1785949 {ECO:0000313|EMBL:KXS44479.1, ECO:0000313|Proteomes:UP000070439};
RN [1] {ECO:0000313|EMBL:KXS44479.1, ECO:0000313|Proteomes:UP000070439}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=T328-2 {ECO:0000313|EMBL:KXS44479.1};
RA Wolfe R., Daly R., Wrighton K.;
RT "Candidatus Frackibacter-2 T328 Annotated.";
RL Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=diphosphate + H2O = H(+) + 2 phosphate; Xref=Rhea:RHEA:24576,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019,
CC ChEBI:CHEBI:43474; EC=3.6.1.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000926};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KXS44479.1}.
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DR EMBL; LSBO01000024; KXS44479.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A139CTH3; -.
DR PATRIC; fig|1785949.3.peg.582; -.
DR Proteomes; UP000070439; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0004427; F:inorganic diphosphate phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 3.10.310.20; DHHA2 domain; 1.
DR Gene3D; 3.40.1390.20; HprK N-terminal domain-like; 1.
DR Gene3D; 3.90.1640.10; inorganic pyrophosphatase (n-terminal core); 2.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR001667; DDH_dom.
DR InterPro; IPR038763; DHH_sf.
DR InterPro; IPR004097; DHHA2.
DR InterPro; IPR038222; DHHA2_dom_sf.
DR InterPro; IPR010766; DRTGG.
DR InterPro; IPR028979; Ser_kin/Pase_Hpr-like_N_sf.
DR PANTHER; PTHR12112; BNIP - RELATED; 1.
DR PANTHER; PTHR12112:SF22; MANGANESE-DEPENDENT INORGANIC PYROPHOSPHATASE; 1.
DR Pfam; PF00571; CBS; 2.
DR Pfam; PF01368; DHH; 1.
DR Pfam; PF02833; DHHA2; 1.
DR Pfam; PF07085; DRTGG; 1.
DR SMART; SM00116; CBS; 2.
DR SMART; SM01131; DHHA2; 1.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF64182; DHH phosphoesterases; 1.
DR SUPFAM; SSF75138; HprK N-terminal domain-like; 1.
DR PROSITE; PS51371; CBS; 2.
PE 4: Predicted;
KW CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}.
FT DOMAIN 73..130
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 253..310
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
SQ SEQUENCE 545 AA; 60854 MW; F46B94337D1B517C CRC64;
MFKEKLVIGH QNPDTDSICS AIGYAELKQK QGENVVAARC GKLNPETEFV LDYFDLPAPK
LVTDVYTRVS DIMEKSNLKS VLPSTPIKEV GELLEQEAIK VIPVVDKDNK LLGIVTASDI
AHRYLQELAV ESLREVPTSL ENIIQTLDGE LINNQQDLSS EVTGNIFTGA MDTETMCEYI
NPGDIVLLGN RIKAQEAVLE REISCLIVTG NLEIKSEVKD LAIEKGITVI RVPYDTFAAA
RLINMSIPIS KVMSTEVEKF YPDELVEDVK EEIINSAHRS YPVTDRQNRL LGLVSARNLI
DVETKEVILV DHNEKSQAVD GIEEATLVEV IDHHRLGDLE TLEPILVRNE PVGSTATIIA
KLYFEYGVEL SVEIAGVLLS AILSDTVIFR SPTCTGVDKM IAEKLAEIVE VEIEKFGRRL
FKAGSVLNKL EPRELILNDY KEYKFDEIKI GVGQIEIMDL AEFKEMQHNI LNVMNEVKKE
SGNDYLFLLV TDVLNEGSLL LYNQTATSLV KRNFVGEEEE VGFYLPGVMS RKKQVIPVLS
KALID
//
