ID   A0A139H7U6_9PEZI        Unreviewed;       780 AA.
AC   A0A139H7U6;
DT   06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT   06-JUL-2016, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   RecName: Full=Transketolase-like pyrimidine-binding domain-containing protein {ECO:0000259|SMART:SM00861};
GN   ORFNames=AC578_2604 {ECO:0000313|EMBL:KXS98491.1};
OS   Pseudocercospora eumusae.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC   Dothideomycetidae; Mycosphaerellales; Mycosphaerellaceae; Pseudocercospora.
OX   NCBI_TaxID=321146 {ECO:0000313|EMBL:KXS98491.1, ECO:0000313|Proteomes:UP000070133};
RN   [1] {ECO:0000313|EMBL:KXS98491.1, ECO:0000313|Proteomes:UP000070133}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 114824 {ECO:0000313|EMBL:KXS98491.1,
RC   ECO:0000313|Proteomes:UP000070133};
RA   Chang T.-C., Salvucci A., Crous P.W., Stergiopoulos I.;
RT   "Comparative genomics of the Sigatoka disease complex on banana suggests a
RT   link between parallel evolutionary changes in Pseudocercospora fijiensis
RT   and Pseudocercospora eumusae and increased virulence on the banana host.";
RL   Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Co(2+); Xref=ChEBI:CHEBI:48828;
CC         Evidence={ECO:0000256|ARBA:ARBA00001941};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- COFACTOR:
CC       Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC         Evidence={ECO:0000256|ARBA:ARBA00001964};
CC   -!- SIMILARITY: Belongs to the transketolase family.
CC       {ECO:0000256|ARBA:ARBA00007131}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KXS98491.1}.
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DR   EMBL; LFZN01000112; KXS98491.1; -; Genomic_DNA.
DR   STRING; 321146.A0A139H7U6; -.
DR   OrthoDB; 5399939at2759; -.
DR   Proteomes; UP000070133; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR   GO; GO:1901135; P:carbohydrate derivative metabolic process; IEA:UniProt.
DR   GO; GO:0006163; P:purine nucleotide metabolic process; IEA:UniProt.
DR   CDD; cd07033; TPP_PYR_DXS_TK_like; 1.
DR   CDD; cd02012; TPP_TK; 1.
DR   Gene3D; 3.40.50.920; -; 1.
DR   Gene3D; 3.40.50.970; -; 2.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR009014; Transketo_C/PFOR_II.
DR   InterPro; IPR005475; Transketolase-like_Pyr-bd.
DR   InterPro; IPR020826; Transketolase_BS.
DR   InterPro; IPR033248; Transketolase_C.
DR   InterPro; IPR033247; Transketolase_fam.
DR   InterPro; IPR005474; Transketolase_N.
DR   PANTHER; PTHR43522; TRANSKETOLASE; 1.
DR   PANTHER; PTHR43522:SF6; TRANSKETOLASE-LIKE PYRIMIDINE-BINDING DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR   Pfam; PF02779; Transket_pyr; 1.
DR   Pfam; PF02780; Transketolase_C; 1.
DR   Pfam; PF00456; Transketolase_N; 1.
DR   SMART; SM00861; Transket_pyr; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
DR   SUPFAM; SSF52922; TK C-terminal domain-like; 1.
DR   PROSITE; PS00802; TRANSKETOLASE_2; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000070133};
KW   Thiamine pyrophosphate {ECO:0000256|ARBA:ARBA00023052};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          436..616
FT                   /note="Transketolase-like pyrimidine-binding"
FT                   /evidence="ECO:0000259|SMART:SM00861"
SQ   SEQUENCE   780 AA;  86811 MW;  9B23A5D7F2495786 CRC64;
     MAPGAVSTQD IDHLPIDLNG KKSNGISNGD VADIQLEEKS KTDHVLNTFR CLVADLCHQF
     GCGHPGSAMG MAAIGVALWK YVMKISPSNP NYFNRDRFVL SNGHACLWQY CFLHLVGFEQ
     MTWEQLLSYH SVRFDSVTPG HPEIEIDGVE VTTGPLGQGI ANAVGLAMAT KHLGAQYNRP
     GYELVNNMTW CTIGDACLQE GVGMEAIQLA GHWKLNNLCV IFDRNEVTCD GTVDICTSDD
     HNMKFRACGW NVLEVEDGNN DVEGLVKAMI QARASKDKPT VINVRTTIGH GSEKAGQAST
     HGADLGEKDV AYVKRFFGMD PEKKFQIDDD VYSYFREVVP RGKDLEKQWH ELRQGYAKEY
     PSLAAEFDKR VKGEMIEDWT KLIPKTEDFP TEDTPTRKAA GQIMAGXXXX XXXXXXXXXX
     XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXADL TPSVHLSWKD KIDFQHPDLR
     TVSGPNGKYS GRYIHWGIRE QAMAACSNGL AAFNRGTIIP ITSSFFMFYI YCANGVRMGA
     LQNLRTIHLA THDSIGTGED GPTHQPIELA ALYRAMPNFL YIRPADSEEC AGAILAALHA
     PETPSMISVS RHKLPQYPSL SSRTGVLKGA YILLDTESPD ITLIGVGAEL KFALEAHALL
     LKTHNIKSRI VSFPCHRLFE RQTPEYKRLV LGTAPRFVIE AYSRLGWEGY ADAGFHMRTF
     GQSLTGDVVY ERFGFTGEKI AEKCREFLEE VERNGMGSLR GLYRDWNDYE EGVQFAAYRK
//