ID A0A139NMA3_9STRE Unreviewed; 467 AA.
AC A0A139NMA3;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=Regulatory protein MsrR {ECO:0000256|ARBA:ARBA00040752};
GN ORFNames=STRDD12_00161 {ECO:0000313|EMBL:KXT77027.1};
OS Streptococcus sp. DD12.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=1777880 {ECO:0000313|EMBL:KXT77027.1, ECO:0000313|Proteomes:UP000070638};
RN [1] {ECO:0000313|EMBL:KXT77027.1, ECO:0000313|Proteomes:UP000070638}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DD12 {ECO:0000313|EMBL:KXT77027.1,
RC ECO:0000313|Proteomes:UP000070638};
RA Denapaite D., Rieger M., Koendgen S., Brueckner R., Ochigava I.,
RA Kappeler P., Maetz-Rensing K., Leendertz F., Hakenbeck R.;
RT "Highly variable Streptococcus oralis are common among viridans
RT streptococci isolated from primates.";
RL Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in SarA attenuation. Affects resistance to oxacillin
CC and teicoplanin, as well as the synthesis of virulence factors.
CC {ECO:0000256|ARBA:ARBA00037178}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004401};
CC Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004401}.
CC -!- SIMILARITY: Belongs to the LytR/CpsA/Psr (LCP) family.
CC {ECO:0000256|ARBA:ARBA00006068}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KXT77027.1}.
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DR EMBL; LQRG01000001; KXT77027.1; -; Genomic_DNA.
DR RefSeq; WP_066913998.1; NZ_KQ969495.1.
DR AlphaFoldDB; A0A139NMA3; -.
DR STRING; 1777880.STRDD12_00161; -.
DR PATRIC; fig|1777880.3.peg.163; -.
DR OrthoDB; 9782542at2; -.
DR Proteomes; UP000070638; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 3.40.630.190; LCP protein; 1.
DR InterPro; IPR004474; LytR_CpsA_psr.
DR NCBIfam; TIGR00350; lytR_cpsA_psr; 1.
DR PANTHER; PTHR33392; POLYISOPRENYL-TEICHOIC ACID--PEPTIDOGLYCAN TEICHOIC ACID TRANSFERASE TAGU; 1.
DR PANTHER; PTHR33392:SF8; REGULATORY PROTEIN MSRR; 1.
DR Pfam; PF03816; LytR_cpsA_psr; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000070638};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 140..160
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 209..384
FT /note="Cell envelope-related transcriptional attenuator"
FT /evidence="ECO:0000259|Pfam:PF03816"
FT REGION 42..82
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 96..131
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 49..63
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 467 AA; 52895 MW; 3896DB323F2237A3 CRC64;
MARHSYLSRH EELRYNYLLK NISFLSARER EEFDYLDQKK KGYFEANPGP SQASYQTRDY
WADEAPSQSY EPEDWAQDRE RLPDEDQDVY YDRLQTYQKP SANRPRNRQR QAPVYADEGN
PAPQRPPKVR RRRKIRWKRI LACIGALVLL IVGLMGYNVY KGYKSVTASN SNYSPAVKEV
FHGEDSEDGT NILILGSDQR VTQGSTDART DTIMVVNVGN KEGKIKMVSF MRDTLVNIED
VSDTTTEPDV KLNTAFSIGE QNNNQGAELM RQTLKRNFGI KIKYYALVDF QTFAEAIDTL
FPKGVDIDAQ FATVDGQAVS SVEVPDDLNA ANGVTPNQTI SVGKQKMDGR TLLNYARFRK
DDEGDYGRTK RQQQVMQAIM TQIKNPTKLF TGSEAIGKVF GLTSTNLPYT FLLTHGVSLV
KDASNGIEQT TIPANGDWVD VYDKYGGAAL YIDRDSYKTK LKEMGLE
//
