ID A0A139SWF1_9GAMM Unreviewed; 518 AA.
AC A0A139SWF1;
DT 11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT 11-MAY-2016, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=AXE65_10950 {ECO:0000313|EMBL:KXU38956.1};
OS Ventosimonas gracilis.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC Ventosimonadaceae; Ventosimonas.
OX NCBI_TaxID=1680762 {ECO:0000313|EMBL:KXU38956.1, ECO:0000313|Proteomes:UP000072660};
RN [1] {ECO:0000313|EMBL:KXU38956.1, ECO:0000313|Proteomes:UP000072660}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CV58 {ECO:0000313|EMBL:KXU38956.1,
RC ECO:0000313|Proteomes:UP000072660};
RA Wen L., He K., Yang H.;
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KXU38956.1}.
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DR EMBL; LSZO01000058; KXU38956.1; -; Genomic_DNA.
DR RefSeq; WP_068387842.1; NZ_LSZO01000058.1.
DR AlphaFoldDB; A0A139SWF1; -.
DR OrthoDB; 9784823at2; -.
DR Proteomes; UP000072660; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 1.20.1260.30; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR022749; D12N6_MeTrfase_N.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR004546; Restrct_endonuc_T1M.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR038333; T1MK-like_N_sf.
DR NCBIfam; TIGR00497; hsdM; 1.
DR PANTHER; PTHR42933:SF1; SITE-SPECIFIC DNA-METHYLTRANSFERASE (ADENINE-SPECIFIC); 1.
DR PANTHER; PTHR42933; SLR6095 PROTEIN; 1.
DR Pfam; PF12161; HsdM_N; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Endonuclease {ECO:0000313|EMBL:KXU38956.1};
KW Hydrolase {ECO:0000313|EMBL:KXU38956.1};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Nuclease {ECO:0000313|EMBL:KXU38956.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000072660};
KW Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 10..158
FT /note="N6 adenine-specific DNA methyltransferase N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF12161"
FT DOMAIN 171..479
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
SQ SEQUENCE 518 AA; 57720 MW; 15F8D70DB8B66E34 CRC64;
MTSTQQRAAL QRQIWQIAND VRGAVDGWDF KQYVLGTLFY RFISENFTAY IEADDDCIQY
AKLSDSVITP EIKDDAIKTK GYFIYPSQLF VNVAASANTN ESLNTDLARI FAAVESSANG
YPSERDIKGL FADFDTTSNR LGNTVADKNS RLAAVLKRVA ELDFGDFKDN HIDLFGDAYE
FLISNYAANA GKSGGEFFTP QNVSKLIARL AMHKQASVNK IYDPACGSGS LLLQAKKQFD
EHIIEDGFYG QEINHTTYNL ARMNMFLHNI NYDKFNIQLG DTLRSPHFGD EKPFDAIVSN
PPYSVKWIGG DDPTLINDDR FAPAGVLAPK SKADFAFVLH ALHYLSAKGR AAIVCFPGIF
YRGGAEQKIR QYLVDNNYVE SVISLAPNLF FGTTIAVNIL VLSKHKADTN TQFIDASSLF
KKETNNNVLL DSHIEQIMSV FDSKADVEHF AKSVNHDVIA DNDYNLSVSS YVQAKDTREE
MDIAKLNAEL KTTVARIDQL RKDIDAIVAE IEGRGQEA
//
