ID A0A139TRK2_9BACT Unreviewed; 1050 AA.
AC A0A139TRK2;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=HMPREF3039_01557 {ECO:0000313|EMBL:KXU54229.1};
OS Akkermansia sp. KLE1798.
OC Bacteria; Verrucomicrobiota; Verrucomicrobiae; Verrucomicrobiales;
OC Akkermansiaceae; Akkermansia.
OX NCBI_TaxID=1574265 {ECO:0000313|EMBL:KXU54229.1, ECO:0000313|Proteomes:UP000070454};
RN [1] {ECO:0000313|EMBL:KXU54229.1, ECO:0000313|Proteomes:UP000070454}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KLE1798 {ECO:0000313|EMBL:KXU54229.1,
RC ECO:0000313|Proteomes:UP000070454};
RA Wen L., He K., Yang H.;
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KXU54229.1}.
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DR EMBL; LTZM01000033; KXU54229.1; -; Genomic_DNA.
DR RefSeq; WP_067571544.1; NZ_KQ971081.1.
DR AlphaFoldDB; A0A139TRK2; -.
DR PATRIC; fig|1574265.3.peg.1514; -.
DR OrthoDB; 9810135at2; -.
DR Proteomes; UP000070454; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}.
FT DOMAIN 1..467
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 468..717
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 11..18
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1050 AA; 118604 MW; 18A43D9CBCB4C8EC CRC64;
MSALTNILIS ASAGTGKTYQ LSLRFLALLV LNRGSHPERL IAVTFTRKAA GEFKDRILTD
LAAGATDSAG AARLRDRLWA VIKGTPEEPG LWPQAAESWK KEHLCQERFR HMLRLLVQQL
SRLNLCTIDS LFAQIAATST FELGVSGFSM IDTTAEKLAR REALLTLYRE CSLNPEQEQS
FEDAFLSGAD SDAEAADAED SMARRLNTYH ELFLDESDTG KWGNPATLGF TPEELLPPVP
LERFNAALHA LMDRARDMPA PEGRNGAKNK EMFLRFLNGF STYVKLGRLK FHDTEKKLTM
EEAREKFRDF WSPPLDELIQ SWLRMETLQA LHRTRSTHGL MRIFEDKYSA LVRNKGRFLF
HDVTRMLGNG AVTPELKRDL QYRMYCRYDH WMLDEFQDTS QSQWRVIKPF LDDLTDTREE
QEGSIFVVGD LKQSVYQWRG GDPALFRSVA GQLHLEERGM ATSYRSVQPV LDMVNDICDY
ARTAADCGQA ALEQWGDYPP HVCAPSLASR TGCARIWQTP RAEETSANDL VCQAMADILE
QSNALRRGLD VAVLVSTRNQ ALIVREWLTS HGWPAEVCDD VPVGQDSPLG KTLLSFFRWL
LSPGDAFISG LLSHSPLHPL ISPDRRPGMD WNGWHMVLER EGYAAIMTEL EKRMALAGVE
LTDFHRDRLS VWMNEAEQVD ERGASLDEWI RRMEDLTRRE DPSGGIVRIM TIHKSKGLGF
DMVILPQIGK DAPFADSRHL THFVKRDGNG LVEGIVMAPS KQVYTAVPQF HALYESWKAT
QQFDGFCKLY VALTRARRAC HIILPGREGK GELRTESMWK IIRSAALAAS CGTEDTLPES
GAECLYSRGE PEWYAELPEK DTRTEPENAP EWPVHKPLLR QRVSPSGLDG ENGLFRSMHD
AALRESAAFG SAVHAVFERI TRWNGEDKPH WVLHPVTEAE RTVAACMDVP AIRELFMPAE
TAIVMKEQRI EAIDGNVWIS GVIDRLVIDG DSACIVDFKT DHADTAEQLR ERHGAQLQAY
ARIVSKITRI PCDRIRRMII STHLKTVIQV
//