ID A0A139W8Y1_TRICA Unreviewed; 1274 AA.
AC A0A139W8Y1;
DT 11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT 11-MAY-2016, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Protein unc-13 homolog B-like Protein {ECO:0000313|EMBL:KXZ75744.1};
GN Name=AUGUSTUS-3.0.2_31721 {ECO:0000313|EMBL:KXZ75744.1};
GN ORFNames=TcasGA2_TC031721 {ECO:0000313|EMBL:KXZ75744.1};
OS Tribolium castaneum (Red flour beetle).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Tenebrionidae; Tenebrionidae incertae sedis; Tribolium.
OX NCBI_TaxID=7070 {ECO:0000313|EMBL:KXZ75744.1, ECO:0000313|Proteomes:UP000007266};
RN [1] {ECO:0000313|EMBL:KXZ75744.1, ECO:0000313|Proteomes:UP000007266}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Georgia GA2 {ECO:0000313|EMBL:KXZ75744.1,
RC ECO:0000313|Proteomes:UP000007266};
RX PubMed=18362917; DOI=10.1038/nature06784;
RG Tribolium Genome Sequencing Consortium;
RA Richards S., Gibbs R.A., Weinstock G.M., Brown S.J., Denell R.,
RA Beeman R.W., Gibbs R., Beeman R.W., Brown S.J., Bucher G., Friedrich M.,
RA Grimmelikhuijzen C.J., Klingler M., Lorenzen M., Richards S., Roth S.,
RA Schroder R., Tautz D., Zdobnov E.M., Muzny D., Gibbs R.A., Weinstock G.M.,
RA Attaway T., Bell S., Buhay C.J., Chandrabose M.N., Chavez D.,
RA Clerk-Blankenburg K.P., Cree A., Dao M., Davis C., Chacko J., Dinh H.,
RA Dugan-Rocha S., Fowler G., Garner T.T., Garnes J., Gnirke A., Hawes A.,
RA Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N., Joshi V.,
RA Khan Z.M., Jackson L., Kovar C., Kowis A., Lee S., Lewis L.R., Margolis J.,
RA Morgan M., Nazareth L.V., Nguyen N., Okwuonu G., Parker D., Richards S.,
RA Ruiz S.J., Santibanez J., Savard J., Scherer S.E., Schneider B.,
RA Sodergren E., Tautz D., Vattahil S., Villasana D., White C.S., Wright R.,
RA Park Y., Beeman R.W., Lord J., Oppert B., Lorenzen M., Brown S., Wang L.,
RA Savard J., Tautz D., Richards S., Weinstock G., Gibbs R.A., Liu Y.,
RA Worley K., Weinstock G., Elsik C.G., Reese J.T., Elhaik E., Landan G.,
RA Graur D., Arensburger P., Atkinson P., Beeman R.W., Beidler J., Brown S.J.,
RA Demuth J.P., Drury D.W., Du Y.Z., Fujiwara H., Lorenzen M., Maselli V.,
RA Osanai M., Park Y., Robertson H.M., Tu Z., Wang J.J., Wang S., Richards S.,
RA Song H., Zhang L., Sodergren E., Werner D., Stanke M., Morgenstern B.,
RA Solovyev V., Kosarev P., Brown G., Chen H.C., Ermolaeva O., Hlavina W.,
RA Kapustin Y., Kiryutin B., Kitts P., Maglott D., Pruitt K., Sapojnikov V.,
RA Souvorov A., Mackey A.J., Waterhouse R.M., Wyder S., Zdobnov E.M.,
RA Zdobnov E.M., Wyder S., Kriventseva E.V., Kadowaki T., Bork P., Aranda M.,
RA Bao R., Beermann A., Berns N., Bolognesi R., Bonneton F., Bopp D.,
RA Brown S.J., Bucher G., Butts T., Chaumot A., Denell R.E., Ferrier D.E.,
RA Friedrich M., Gordon C.M., Jindra M., Klingler M., Lan Q., Lattorff H.M.,
RA Laudet V., von Levetsow C., Liu Z., Lutz R., Lynch J.A., da Fonseca R.N.,
RA Posnien N., Reuter R., Roth S., Savard J., Schinko J.B., Schmitt C.,
RA Schoppmeier M., Schroder R., Shippy T.D., Simonnet F., Marques-Souza H.,
RA Tautz D., Tomoyasu Y., Trauner J., Van der Zee M., Vervoort M.,
RA Wittkopp N., Wimmer E.A., Yang X., Jones A.K., Sattelle D.B., Ebert P.R.,
RA Nelson D., Scott J.G., Beeman R.W., Muthukrishnan S., Kramer K.J.,
RA Arakane Y., Beeman R.W., Zhu Q., Hogenkamp D., Dixit R., Oppert B.,
RA Jiang H., Zou Z., Marshall J., Elpidina E., Vinokurov K., Oppert C.,
RA Zou Z., Evans J., Lu Z., Zhao P., Sumathipala N., Altincicek B.,
RA Vilcinskas A., Williams M., Hultmark D., Hetru C., Jiang H.,
RA Grimmelikhuijzen C.J., Hauser F., Cazzamali G., Williamson M., Park Y.,
RA Li B., Tanaka Y., Predel R., Neupert S., Schachtner J., Verleyen P.,
RA Raible F., Bork P., Friedrich M., Walden K.K., Robertson H.M., Angeli S.,
RA Foret S., Bucher G., Schuetz S., Maleszka R., Wimmer E.A., Beeman R.W.,
RA Lorenzen M., Tomoyasu Y., Miller S.C., Grossmann D., Bucher G.;
RT "The genome of the model beetle and pest Tribolium castaneum.";
RL Nature 452:949-955(2008).
RN [2] {ECO:0000313|EMBL:KXZ75744.1, ECO:0000313|Proteomes:UP000007266}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Georgia GA2 {ECO:0000313|EMBL:KXZ75744.1,
RC ECO:0000313|Proteomes:UP000007266};
RX PubMed=19820115; DOI=10.1093/nar/gkp807;
RA Kim H.S., Murphy T., Xia J., Caragea D., Park Y., Beeman R.W.,
RA Lorenzen M.D., Butcher S., Manak J.R., Brown S.J.;
RT "BeetleBase in 2010: revisions to provide comprehensive genomic information
RT for Tribolium castaneum.";
RL Nucleic Acids Res. 38:D437-D442(2010).
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DR EMBL; KQ972879; KXZ75744.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A139W8Y1; -.
DR EnsemblMetazoa; TC031721_003; TC031721_003; TC031721.
DR Proteomes; UP000007266; Unassembled WGS sequence.
DR GO; GO:0098793; C:presynapse; IEA:UniProt.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0019992; F:diacylglycerol binding; IEA:InterPro.
DR GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR GO; GO:0007268; P:chemical synaptic transmission; IEA:InterPro.
DR CDD; cd04027; C2B_Munc13; 1.
DR CDD; cd08395; C2C_Munc13; 1.
DR Gene3D; 1.10.357.50; -; 1.
DR Gene3D; 1.20.58.1100; -; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR010439; MUN_dom.
DR InterPro; IPR014770; Munc13_1.
DR InterPro; IPR014772; Munc13_dom-2.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR027080; Unc-13.
DR InterPro; IPR037302; Unc-13_C2B.
DR PANTHER; PTHR10480; PROTEIN UNC-13 HOMOLOG; 1.
DR PANTHER; PTHR10480:SF12; UNC-13, ISOFORM E; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF00168; C2; 2.
DR Pfam; PF06292; MUN; 1.
DR PRINTS; PR00360; C2DOMAIN.
DR SMART; SM00109; C1; 1.
DR SMART; SM00239; C2; 2.
DR SMART; SM01145; DUF1041; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR PROSITE; PS50004; C2; 2.
DR PROSITE; PS51258; MHD1; 1.
DR PROSITE; PS51259; MHD2; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000007266};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 63..113
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 232..356
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 664..807
FT /note="MHD1"
FT /evidence="ECO:0000259|PROSITE:PS51258"
FT DOMAIN 917..1083
FT /note="MHD2"
FT /evidence="ECO:0000259|PROSITE:PS51259"
FT DOMAIN 1099..1227
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
SQ SEQUENCE 1274 AA; 144298 MW; D4392F3C2EB5D128 CRC64;
MPDIRPRRKS IPLVSDLTMA ATKRNAGLTS AVPRATLNDE ELKMHVYKKT LQALIYPISS
TTPHNFVPWT ATSPTYCYEC EGLLWGIARQ GVRCTECSVK CHEKCKDLLN ADCLQRAAEK
SSKHGAEDKA NSIITAMKER MKQREREKPE IFELIRAVFG VEDKSHAGHM KAVKQSVLDG
TSKWSAKIAI TVPNSVAMDS LVVVYIFCCI GVLVSGSGRT TFSVDPDTHI DSIEQAEQMT
IEGTSKWSCK IAITVKSAQG LIAKDKSGTS DPYVTVQVGK VKKRTRTMPQ ELNPVWDEKF
YFECHNSSDR IKVRVWDEDN DLKSKLRQKL TRESDDFLGQ TIIEVRTLSG EMDVWYNLEK
RTDKSAVSGA IRLHISVEIK GEEKVAPYHV QYTCLHENLF HYLCEQNSGV VSLPQAKGDD
AWKVYFEEAG EEIVDEFAMR YGIESIYQAM THFHCLSTKY LCPGVPAVMS MLLANINAYY
AHTTASSAVS ASDRFAASNF GKEKFVKLLD QLHNSLRIDL SMYRNNFPAS SPDKLMDLKS
TVDLLTSITF FRMKVQELTC PPRASTVVKD CVKACLRSTY QFLFENTYEL YNREFQSDPN
EPKRDPEDHG PRLDSVDFWH KLIALIVSVI EEDKNSYGPV LNQFPQELNI GQLSAATMWS
LFAVDMKYAL EEHEQHRLCK SSAYMNLHFK VKWLYSNYVK DVPPYKGAVP EYPAWFEPFV
MQWLNENDDV SLEYLHGAFN RDKKDGFQRS SEHALFSNSV VDVFTQLTQC FDVVSKLECP
DPEIWKRYMK RFAKTIVKVL IAYADIVKGE FPEHVKEERI ACILMNNIQQ LRVQLEKMFE
SMGGEKLEED AANILKDLQQ TLNGCLDELA TQFASSLEPR ITVSVKELGD LLLSIKGGGQ
PGTTQPAQRN VVASEADEVL RPLMDLLDGS LSLYAQSCEK TVLKRLLKEL WKIVMRILEK
TVVLPPMTDK TMMFKSLTDN AKNLAAKTKI EDMSTLFKNH MAGKQDVKNA LSGVMDISKE
VEKNLSPKQC AVLDVALDTI KQYFHAGGNG LKKAFLDKSP ELQSLRYALS LYTQTTDTLI
KTFVTTQINE DTLDGQEGSV GEVSIQVDLF THPGTGEHKV TVKVVAANDL KWNVVSGMFR
PFVEVNLIGP HLSDKKRKHA TKSKANNWSP KYNETFHFTI GNEEQLDYFE LHICVKDYCF
AREDRLVGVA VMQLKDIVEK GSCACWLSLG KRIQMDETGW TILRILSQRT NDEVAKEFVK
LKSDIRQENP LPNQ
//
