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Database: UniProt
Entry: A0A139WB50_TRICA
LinkDB: A0A139WB50_TRICA
Original site: A0A139WB50_TRICA 
ID   A0A139WB50_TRICA        Unreviewed;      1877 AA.
AC   A0A139WB50;
DT   11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT   11-MAY-2016, sequence version 1.
DT   27-SEP-2017, entry version 12.
DE   SubName: Full=Voltage-dependent calcium channel type A subunit alpha-1-like Protein {ECO:0000313|EMBL:KYB25147.1};
GN   ORFNames=TcasGA2_TC011226 {ECO:0000313|EMBL:KYB25147.1};
OS   Tribolium castaneum (Red flour beetle).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Coleoptera; Polyphaga;
OC   Cucujiformia; Tenebrionidae; Tenebrionidae incertae sedis; Tribolium.
OX   NCBI_TaxID=7070 {ECO:0000313|EMBL:KYB25147.1, ECO:0000313|Proteomes:UP000007266};
RN   [1] {ECO:0000313|EMBL:KYB25147.1, ECO:0000313|Proteomes:UP000007266}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Georgia GA2 {ECO:0000313|EMBL:KYB25147.1,
RC   ECO:0000313|Proteomes:UP000007266};
RX   PubMed=18362917; DOI=10.1038/nature06784;
RG   Tribolium Genome Sequencing Consortium;
RA   Richards S., Gibbs R.A., Weinstock G.M., Brown S.J., Denell R.,
RA   Beeman R.W., Gibbs R., Beeman R.W., Brown S.J., Bucher G.,
RA   Friedrich M., Grimmelikhuijzen C.J., Klingler M., Lorenzen M.,
RA   Richards S., Roth S., Schroder R., Tautz D., Zdobnov E.M., Muzny D.,
RA   Gibbs R.A., Weinstock G.M., Attaway T., Bell S., Buhay C.J.,
RA   Chandrabose M.N., Chavez D., Clerk-Blankenburg K.P., Cree A., Dao M.,
RA   Davis C., Chacko J., Dinh H., Dugan-Rocha S., Fowler G., Garner T.T.,
RA   Garnes J., Gnirke A., Hawes A., Hernandez J., Hines S., Holder M.,
RA   Hume J., Jhangiani S.N., Joshi V., Khan Z.M., Jackson L., Kovar C.,
RA   Kowis A., Lee S., Lewis L.R., Margolis J., Morgan M., Nazareth L.V.,
RA   Nguyen N., Okwuonu G., Parker D., Richards S., Ruiz S.J.,
RA   Santibanez J., Savard J., Scherer S.E., Schneider B., Sodergren E.,
RA   Tautz D., Vattahil S., Villasana D., White C.S., Wright R., Park Y.,
RA   Beeman R.W., Lord J., Oppert B., Lorenzen M., Brown S., Wang L.,
RA   Savard J., Tautz D., Richards S., Weinstock G., Gibbs R.A., Liu Y.,
RA   Worley K., Weinstock G., Elsik C.G., Reese J.T., Elhaik E., Landan G.,
RA   Graur D., Arensburger P., Atkinson P., Beeman R.W., Beidler J.,
RA   Brown S.J., Demuth J.P., Drury D.W., Du Y.Z., Fujiwara H.,
RA   Lorenzen M., Maselli V., Osanai M., Park Y., Robertson H.M., Tu Z.,
RA   Wang J.J., Wang S., Richards S., Song H., Zhang L., Sodergren E.,
RA   Werner D., Stanke M., Morgenstern B., Solovyev V., Kosarev P.,
RA   Brown G., Chen H.C., Ermolaeva O., Hlavina W., Kapustin Y.,
RA   Kiryutin B., Kitts P., Maglott D., Pruitt K., Sapojnikov V.,
RA   Souvorov A., Mackey A.J., Waterhouse R.M., Wyder S., Zdobnov E.M.,
RA   Zdobnov E.M., Wyder S., Kriventseva E.V., Kadowaki T., Bork P.,
RA   Aranda M., Bao R., Beermann A., Berns N., Bolognesi R., Bonneton F.,
RA   Bopp D., Brown S.J., Bucher G., Butts T., Chaumot A., Denell R.E.,
RA   Ferrier D.E., Friedrich M., Gordon C.M., Jindra M., Klingler M.,
RA   Lan Q., Lattorff H.M., Laudet V., von Levetsow C., Liu Z., Lutz R.,
RA   Lynch J.A., da Fonseca R.N., Posnien N., Reuter R., Roth S.,
RA   Savard J., Schinko J.B., Schmitt C., Schoppmeier M., Schroder R.,
RA   Shippy T.D., Simonnet F., Marques-Souza H., Tautz D., Tomoyasu Y.,
RA   Trauner J., Van der Zee M., Vervoort M., Wittkopp N., Wimmer E.A.,
RA   Yang X., Jones A.K., Sattelle D.B., Ebert P.R., Nelson D., Scott J.G.,
RA   Beeman R.W., Muthukrishnan S., Kramer K.J., Arakane Y., Beeman R.W.,
RA   Zhu Q., Hogenkamp D., Dixit R., Oppert B., Jiang H., Zou Z.,
RA   Marshall J., Elpidina E., Vinokurov K., Oppert C., Zou Z., Evans J.,
RA   Lu Z., Zhao P., Sumathipala N., Altincicek B., Vilcinskas A.,
RA   Williams M., Hultmark D., Hetru C., Jiang H., Grimmelikhuijzen C.J.,
RA   Hauser F., Cazzamali G., Williamson M., Park Y., Li B., Tanaka Y.,
RA   Predel R., Neupert S., Schachtner J., Verleyen P., Raible F., Bork P.,
RA   Friedrich M., Walden K.K., Robertson H.M., Angeli S., Foret S.,
RA   Bucher G., Schuetz S., Maleszka R., Wimmer E.A., Beeman R.W.,
RA   Lorenzen M., Tomoyasu Y., Miller S.C., Grossmann D., Bucher G.;
RT   "The genome of the model beetle and pest Tribolium castaneum.";
RL   Nature 452:949-955(2008).
RN   [2] {ECO:0000313|EMBL:KYB25147.1, ECO:0000313|Proteomes:UP000007266}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Georgia GA2 {ECO:0000313|EMBL:KYB25147.1,
RC   ECO:0000313|Proteomes:UP000007266};
RX   PubMed=19820115; DOI=10.1093/nar/gkp807;
RA   Kim H.S., Murphy T., Xia J., Caragea D., Park Y., Beeman R.W.,
RA   Lorenzen M.D., Butcher S., Manak J.R., Brown S.J.;
RT   "BeetleBase in 2010: revisions to provide comprehensive genomic
RT   information for Tribolium castaneum.";
RL   Nucleic Acids Res. 38:D437-D442(2010).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
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DR   EMBL; KQ971374; KYB25147.1; -; Genomic_DNA.
DR   UniGene; Tca.18730; -.
DR   EnsemblMetazoa; TC011226_004; TC011226_004; TC011226.
DR   Proteomes; UP000007266; Unassembled WGS sequence.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   SMART; SM01062; Ca_chan_IQ; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007266};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007266};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM     37     54       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     75     96       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    108    131       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    166    188       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    255    278       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    290    310       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    444    462       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    474    492       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    569    591       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    646    670       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    771    790       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    810    831       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    843    861       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    907    929       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1021   1046       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1091   1114       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1135   1155       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1167   1191       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1212   1241       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1341   1376       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      673    708       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1877 AA;  213108 MW;  02E49832C5674092 CRC64;
     MGGASAAGGQ GPSSLFLFSE ENPIRRHTRF IIEWPPFEYA VLLTIIANCV VLALEEHLPN
     HDKTLLAQKL EATEVYFLGI FCVEASLKIL ALGFVLHRGS YLRNIWNIMD FFVVLTGCLT
     LFLQDFVAVD LRTLRAIRVL RPLKLVSGIP SLQVVLKSII KAMAPLLQIG LLVLFAIVIF
     AIIGLEFYSG ALHRTCYSLY DIDEIAKEGD AEVPCNTDNE TQARAQGSNW CRDGNSVCLE
     RWQGPNNGIT SFDNIGFAML TVFQCITMEG WTAILYWMND AVGSTFNWMY FVPLIVLGSF
     FMLNLVLGVL SGEFAKEREK VENRQEFLKL RRQAQLEREL NGYVQWICKA EEVILAEERT
     TEEEKLHIME ARRRAAKKKK LKKMGKSKST DTEEEEQEEE VADDGFGRTS YLKSRAKGQG
     GCARFWRAEK RFRFAIRHMV KSQWFYWSVI VLVFFNTFCV AVEYHGQPDW LSKFLYYAEY
     VFLGLFMSEM FLKMYALGPR IYFESAFNRF DCVVITGSIF EVIWSEVKGG SFGLSVLRAL
     RLLRIFKVTK YWSSLRNLVI SLLNSMRSII SLLFLLFLFI LIFALLGMQL FGGQFNFENE
     TPPTNFNTFP IALLTVFQIL TGEDWNEVMY YGIEALGGHD NGGMIYSLYF IILMLFGNYT
     LLNVFLAIAV DNLANAQELT AAEEEQAEEN KEKQALELEK EMEALQMEAG SNPRVEVCPP
     SPIKSRKKKD EKPPDEEEEI VGPKPMLPYS SMFVLSPTNP VRRFAHGIVN LRYFDFFIMV
     VICLSSMALA AEDPVNEDSN WNLILDRLDY AFTGVFAVEM LLKIIDLGII LHPGSYLREF
     WNIMDAAVVI CALVSMGFDV AQNKAGANLS TIKSLRVLRV LRPLKTIKRV PKLKAVFDCL
     VNSLKNVINI LIVYILFQFI FAVIAVQLFN GKFRHCTDAS KFTEATCQGQ YFIFDEDNDV
     PRVEKREWKL QSFHYDDVAM AMLTLFAVQT GEGWPQVLQH SMSATYEDQG PIQNFRIEMS
     IFYIVYFVVF PFFFVNIFVA LIIITFQEQG EAELQSGEID KNQKSCIDFT IQARPLERYM
     PNKRNSFKYK IWRIVVSTPF EYFIMMLIVF NTLLLMMKFD KQSEIYTKTL KYLNWGFTGM
     FTVECFLKIL AFGVRNFFKD PWNTFDFITV IGSIVDAMVV EFGENFINVG FLRLFRAARL
     IKLLRQGYTI RILLWTFVQS FKALPYVCLL IAMLFFIYAI IGMQVFGNIA EIPSASITRH
     NNFRTFIQGL MLLFRCATGE AWPNIMLSCI KGQPCDPEAK KPPNSCGSNI AYAYFMLNLF
     VAVIMDNFDY LTRDSSILGA HHLDEFVRIW AEYDPNATGK IHYIEMYDML KNMDPPLGFG
     NKCPNRLAYK KLIRMNMPVD DEGKVNFTTT LFALIRENLN IKMRPAEEMD QADDELRETI
     KNIWPLQAKN MVDLLVPPND HLNNGKLTVG KLYAGLLILE SWRSTRFGQV EPTGIPGFGN
     SPSANHAKAS FFDCLLDMAG HLGGSRTGSV SLEGAPLMGS QEPPDSHAHE ESSLATLARR
     NTKRNRSMRN KKVMELQEGM GSRRQSCELS QHILPILIGD QHLHPDFLCR RGNSPSLQRS
     PSPRRKYPPH LHHDIGFSDT VSNVVEIVKH EHQRSHSNRR FVRGSWSAST SPARSPSPSD
     IRHNCGYGPL RSSRRGYGTT SLCQRSRSPS PTHPIPHQQG PPIIAGAVVG IPMQQQQQQS
     SSTHESTSVQ HSHPVLGGRR GQGRRLPPTP SKPSTLQLRP GPINFPKLNA SPTHIQSHSA
     HATPHAAPHN YHREVVATSN VPTAATALRD GNQAPLSFEQ AVALGRGGRM LPSPVPNGYK
     PKPTRSRHSD SDDDDWC
//
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