ID A0A139WBF9_TRICA Unreviewed; 4209 AA.
AC A0A139WBF9;
DT 11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT 11-MAY-2016, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Dynein heavy chain 2, axonemal-like Protein {ECO:0000313|EMBL:KYB25181.1};
GN Name=AUGUSTUS-3.0.2_31238 {ECO:0000313|EMBL:KYB25181.1};
GN ORFNames=TcasGA2_TC031238 {ECO:0000313|EMBL:KYB25181.1};
OS Tribolium castaneum (Red flour beetle).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Tenebrionidae; Tenebrionidae incertae sedis; Tribolium.
OX NCBI_TaxID=7070 {ECO:0000313|EMBL:KYB25181.1, ECO:0000313|Proteomes:UP000007266};
RN [1] {ECO:0000313|EMBL:KYB25181.1, ECO:0000313|Proteomes:UP000007266}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Georgia GA2 {ECO:0000313|EMBL:KYB25181.1,
RC ECO:0000313|Proteomes:UP000007266};
RX PubMed=18362917; DOI=10.1038/nature06784;
RG Tribolium Genome Sequencing Consortium;
RA Richards S., Gibbs R.A., Weinstock G.M., Brown S.J., Denell R.,
RA Beeman R.W., Gibbs R., Beeman R.W., Brown S.J., Bucher G., Friedrich M.,
RA Grimmelikhuijzen C.J., Klingler M., Lorenzen M., Richards S., Roth S.,
RA Schroder R., Tautz D., Zdobnov E.M., Muzny D., Gibbs R.A., Weinstock G.M.,
RA Attaway T., Bell S., Buhay C.J., Chandrabose M.N., Chavez D.,
RA Clerk-Blankenburg K.P., Cree A., Dao M., Davis C., Chacko J., Dinh H.,
RA Dugan-Rocha S., Fowler G., Garner T.T., Garnes J., Gnirke A., Hawes A.,
RA Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N., Joshi V.,
RA Khan Z.M., Jackson L., Kovar C., Kowis A., Lee S., Lewis L.R., Margolis J.,
RA Morgan M., Nazareth L.V., Nguyen N., Okwuonu G., Parker D., Richards S.,
RA Ruiz S.J., Santibanez J., Savard J., Scherer S.E., Schneider B.,
RA Sodergren E., Tautz D., Vattahil S., Villasana D., White C.S., Wright R.,
RA Park Y., Beeman R.W., Lord J., Oppert B., Lorenzen M., Brown S., Wang L.,
RA Savard J., Tautz D., Richards S., Weinstock G., Gibbs R.A., Liu Y.,
RA Worley K., Weinstock G., Elsik C.G., Reese J.T., Elhaik E., Landan G.,
RA Graur D., Arensburger P., Atkinson P., Beeman R.W., Beidler J., Brown S.J.,
RA Demuth J.P., Drury D.W., Du Y.Z., Fujiwara H., Lorenzen M., Maselli V.,
RA Osanai M., Park Y., Robertson H.M., Tu Z., Wang J.J., Wang S., Richards S.,
RA Song H., Zhang L., Sodergren E., Werner D., Stanke M., Morgenstern B.,
RA Solovyev V., Kosarev P., Brown G., Chen H.C., Ermolaeva O., Hlavina W.,
RA Kapustin Y., Kiryutin B., Kitts P., Maglott D., Pruitt K., Sapojnikov V.,
RA Souvorov A., Mackey A.J., Waterhouse R.M., Wyder S., Zdobnov E.M.,
RA Zdobnov E.M., Wyder S., Kriventseva E.V., Kadowaki T., Bork P., Aranda M.,
RA Bao R., Beermann A., Berns N., Bolognesi R., Bonneton F., Bopp D.,
RA Brown S.J., Bucher G., Butts T., Chaumot A., Denell R.E., Ferrier D.E.,
RA Friedrich M., Gordon C.M., Jindra M., Klingler M., Lan Q., Lattorff H.M.,
RA Laudet V., von Levetsow C., Liu Z., Lutz R., Lynch J.A., da Fonseca R.N.,
RA Posnien N., Reuter R., Roth S., Savard J., Schinko J.B., Schmitt C.,
RA Schoppmeier M., Schroder R., Shippy T.D., Simonnet F., Marques-Souza H.,
RA Tautz D., Tomoyasu Y., Trauner J., Van der Zee M., Vervoort M.,
RA Wittkopp N., Wimmer E.A., Yang X., Jones A.K., Sattelle D.B., Ebert P.R.,
RA Nelson D., Scott J.G., Beeman R.W., Muthukrishnan S., Kramer K.J.,
RA Arakane Y., Beeman R.W., Zhu Q., Hogenkamp D., Dixit R., Oppert B.,
RA Jiang H., Zou Z., Marshall J., Elpidina E., Vinokurov K., Oppert C.,
RA Zou Z., Evans J., Lu Z., Zhao P., Sumathipala N., Altincicek B.,
RA Vilcinskas A., Williams M., Hultmark D., Hetru C., Jiang H.,
RA Grimmelikhuijzen C.J., Hauser F., Cazzamali G., Williamson M., Park Y.,
RA Li B., Tanaka Y., Predel R., Neupert S., Schachtner J., Verleyen P.,
RA Raible F., Bork P., Friedrich M., Walden K.K., Robertson H.M., Angeli S.,
RA Foret S., Bucher G., Schuetz S., Maleszka R., Wimmer E.A., Beeman R.W.,
RA Lorenzen M., Tomoyasu Y., Miller S.C., Grossmann D., Bucher G.;
RT "The genome of the model beetle and pest Tribolium castaneum.";
RL Nature 452:949-955(2008).
RN [2] {ECO:0000313|EMBL:KYB25181.1, ECO:0000313|Proteomes:UP000007266}
RP GENOME REANNOTATION.
RC STRAIN=Georgia GA2 {ECO:0000313|EMBL:KYB25181.1,
RC ECO:0000313|Proteomes:UP000007266};
RX PubMed=19820115; DOI=10.1093/nar/gkp807;
RA Kim H.S., Murphy T., Xia J., Caragea D., Park Y., Beeman R.W.,
RA Lorenzen M.D., Butcher S., Manak J.R., Brown S.J.;
RT "BeetleBase in 2010: revisions to provide comprehensive genomic information
RT for Tribolium castaneum.";
RL Nucleic Acids Res. 38:D437-D442(2010).
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR EMBL; KQ971372; KYB25181.1; -; Genomic_DNA.
DR STRING; 7070.A0A139WBF9; -.
DR EnsemblMetazoa; TC031238_001; TC031238_001; TC031238.
DR eggNOG; KOG3595; Eukaryota.
DR InParanoid; A0A139WBF9; -.
DR OMA; MYPALIN; -.
DR Proteomes; UP000007266; Linkage group 9.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd00009; AAA; 1.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF32; DYNEINS HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 3.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000007266}.
FT DOMAIN 1849..1985
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2128..2264
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2463..2610
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2808..2866
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3038..3100
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3351..3378
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 7..33
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4209 AA; 485467 MW; 6E1384AC0697596A CRC64;
MTTPSPLDEA EEKDSLFSDK SEDKAVKIQT PEAETSEHVK VSYTDEDLDK LVGFVRNLTT
LYDLRPDDWK EENYEVIKRF FLTPTEPILT IYFVNDDLIC SLGPPVKSVM DLTYFLRQPF
EVFEVATFFD NINFGTMDDN IEGSILNIVE NIYAPVFFKS NHWPESVKND FSHNLHMFLS
KFTDVHSRLF GLTVLYIPRE ALDIPVDVAS LDKELVKRME AIVVYWTKQI RVGLQDQDQN
TPDDLLTPLD EYDFWVYRFE NLSGLNYQLT NESLKHICNI LIAVQSTYVH QFLILADEIE
RNVKESMSNI EYLAVLRKPC TELSEIENPN EMHTKLAEIL HLIRFIWMNS PYYNTIEKIT
SLCRALSNQV ILQCTKYINM DILFEEKKSR EGIKMFETCI ECLTNYIRTY VLISESHTMF
GPSPWLLDKA PIFNHVDSFI QRCKDMIEIC EAMINFGRHD ETEEIPKPNF GGSRRIEFLN
WCNKVEDMFA ESLKSVQEVK HLILDVQVST WYDQMLQFKN RMKDIEVVIE NLTNAVFEEV
ANVEEGIESL AALYNYSKRE SLKALFDGKT LFVYEMFKEE IHGVKKELTE SEMYPARLPY
YAGRAMIANM KKNRLVLIRK FFDDAKWMLP CSVSQEIFSQ YEKLVSSIDE RILGLYRKWN
DRLGEDVAKR LHRPLMCKSI SKPGLLECNI DRSLLEIFTE ARYWESLNYE VPSHIKSVYD
KANNVRFVYE SVLAVVLDYN KILASLSDDE RLLFKPLITI VEKKIAPGLS KLTWASEVSD
EYIAECSHNT AELQQFLDDY KSCNLQIVTI CEKVCDTYMF RITPNYVFNI RELIIEISTQ
LEKTMEKLVI HYQNIIQFLI LVFEGFENYM TVMANQWITY INNFDTLVEE ALKISCRNTL
NHMYECLHGD DTLGPNPVLE LTASLKANRI NFEPTLSEVA KVVHNILPNM VEALTTLPRL
NDKFHVAETD FTPYWGIIEQ DAECQKIQKM LNDEMSLNVK KIQEYMTIWE PFRDLWEIDK
DLFMTKYETE NPTAAQFDAN IGRYTEVANN VQIQEGVTVV HFIRINCSEL KKSIIEHCLQ
WQMKLCQLLY KLTVRNIDDV YEYIKVNTEA VLKEPQNLIE MEKAIALHER LVNEVSQKEE
TFPFITDQML VLEKYNVSVS NEVRNREKAI PNEWSRYLDV LSDADKMLGY SKDTFKTRLL
EDAEVLKKDG KKLLDDFLAT GPFSSDWSAE DALKYIADIK AKLAYLREHE KDLRGDLGIF
GLSLPDTIEL TKLEREIAAI ELVWQLTDEW NKAWEKYKSG EFWTIETEEM EVTAQTLFRK
LTRLSRELKD KNWEIVDHTR QRVDAFRRTL PLIGDLKNPS MRPRHWDRVR KVVGKDFDEN
GPEFNLEAIY AMEMHKYAEE INDISNAATM ELQIEKGLAN IAHIWKDIKI EMVPHKDKGL
YRIKSVEECF QTLEDHMLQL STMKSTRFVE PFAKEVDYWE RTLSYILETL EAALTVQRQW
LYLENIFFGE DIRKQLPRES EGFDRLSEEW KNITIHMHAG KTAMKATQYE PAPYLYNKLN
RMNDKLELIQ RALERYLETK RHIFPRFYFI SNDDMLEILG NSKKPEAVQP HLKKLFDNLT
KLKMQRNLVT GKQEAMGMFS EDGEYMDFTK LIVLDGPVEM WLLEVEAQMR AALKKEFKPC
RSALKKMLSK RDKWLLSYCG QLCNACSQIQ WTTDCTKALV HAKITDSKKP LKKLRKKQNQ
VLSKLSELSR RELTKLQRLK ANALITIEIH SRDVIDKMYK ANCRDTNSFE WFSQLRFYWD
RDLDDCVIKQ TNTAFMYGYE YNGNSGRLVI TPLTDRCYIT LTTALHLFRG GSPKGPAGTG
KTETVKDLGK AMGMWVIVNN CSEGLDYKSM GKCFSGLAQT GAWGCFDEFN RINIEVLSVV
AQQILSILSA IARKMKQFVF EGTEINLKLT CGIFITMNPG YAGRTELPDN LKSMFRPISM
MVPDSAIIAE NILFSDGFQN TKTLSKKVFT LYQLAMQQLS KQDHYDFGLR SMVALLRYGG
RKRRQFPHFP EDEIIYLAMR DMNIARLTSD DLPLFNGIMS DIFPGVSIPK VDYVDMTDAI
VSHMKENGLQ PIENAITKII QLYETKSSRH SVMILGQTGS AKSTTWKTLQ GALGILHKAG
KPGFNVVHVY AINPKALNLG ELYGEYNLST NEWLDGVISA VMRTTCAEET PDEKWILFDG
PVDAVWIENM NSVMDDNKIL TLINSDRITM PEQVSLLFEV GDLSVASPAT VSRCGMVYND
YKDWGWLPYV TSWVQKQHKR GKEFQDIMMD FFHVYLQKIL DFKRLHCEEA AGCVELNLVM
SLCKLLEILA TVENGVNPHD EDNFADMAKN WFLFCLIWSV CCTTNEEGRK KIDNFIREKE
GVFPIKDTIY EYFVDVPNKS FALWEVKLPY DWKYDPGCAF FEIIVPTVDT VRYEYITNAL
LSHGYPVLLT GPVGTSKTST AQSVLASLSS EKYTVLNINM SAQTSSLNLQ EAIESRLEKR
TKGVYAPVGG KLLITFLDDL NMPAKETYGS QPPLELLRQW LDYNFWYDRQ KQTKKFVINM
HILAAMGPPG GGRNVISERL LSIFNVINIT FPDETNILRI YGTMLGQHLA DFNEVVKIVG
REITETTIDL YNNIKSKLAN AAKKAGVFPT SEAMYNFLIK RVRANLHIII CMSPIGDAFR
NRLRQYPALV NCTTIDWFCE WPKVALLEVA NKYITDVNFV QTITGEVLGK RRASVLLSSQ
DRLREAVAST FATIHDSVAK CARRMAIEMK RHSYVTPTNY LELVAGYKKM LQEKRDEVSA
QANKLRNGLW KIEDCRNKVQ SMSIELEEAQ VKVAEFQQQC DEYLVIIVAQ RKQADEQQKE
VTQKSIKIRE DEVQCQKLAD VAQADLDEAM PALEEAIRAL DSLSKKDISE MKSYGKPPAK
VEMVMEAIMI LKQVEPTWAE SKRQLGEINF LKDLKDFDKN HISDRTLKKV ANYTQNPEFI
PEKVGTVSFA AKSLCQWVIA IEKYARVWKI VEPKQMKFDE AMASLREKQA MLAEAQAKLA
ELNIMLARLQ KEYEEKLEQK EELNRKAELL KIKLERAYIL VECLAGEKTR WEETVAKLDI
SFDCLPGDCL LATAFLSYLG PYVSNYREEL MEMWKNEVAT LEIPYSTNFE IISFLTDPTT
VREWNLQGLP ADGFSTENGI IVTTGQRWPL VIDPQCQAQK WIKNMEAVNN LKVVDFGMHS
YMKILEDAVQ NGKPVLLQNI LETMDPSLNS ILAKAVVKQG GMNLIKIDDK MVSYNDDFRF
FITTKLTNPH YPPEISTKTT LVNFAVKEQG LEAQLLGIVV RKERPQLEEQ KDKLVTAIAK
GKRQLIDLEN ELLRLLNETR GSLLEDAELF NTLQTSKATS IAVAKSLETA ETTEVQIDMA
REGYRPCAER ASILFFVLND LGRIDPMYQF ALDSYIFLFE KSIQNSTKSQ ILSERIMELN
DYHTYSVYRN TCRTLFEHHK LMFSFHMCVK ILENMGKVVK AEYNFLLRGG VVLDKENQMD
NPCAAWLSDE GWDNITELDK IAGFHGIIDT FEQYPREWHA WYTHTEPETL PLIAEWNEIC
NNFQKMLFIR SLRQDRMSFC ITNFIINQLG SKFVEPPVLD IKAVLEESVA QTPLIFVLSP
GVDPTTALMQ LAESAGMMGA FQSLSLGQGQ SPIATRMIQR GAKEGHWVFL ANCHLSLSWM
PQLDKIVETL QTGKINPRAN LTRLYQLITE EQFSVCQCQE KYKKLLFSLC FFHAILLERK
KFQQLGWNVI YSFNDSDFEV SENLLTIYLD EYENTPWDAL KYLIAGVNYG GHVTDDWDRR
LLLTYINQYF CDDVLNIPYH RLSSLPTYYI PRDGSLQTYQ DYVRLLPTID RPEAFGQHPN
ADITSLITES RMFCETLMSL EIQSSSGESE SQEDKVSQLA AEVLSKIPNP IDYETTEKLI
GVDKKPLDVV LLQEILRYNT LLVDIRTSLD ELQKGIKGLV VMSSQLEEIF TCIFEGRVPS
DWLKAYASLK LLGSWTRDLI ARVEHFETWA STTHPPMFFW LSAYTFPTGF LTAVLQTTAR
ANEVPIDTLS WEFTVITVDE SQLIERPENG VYVKGMFLEG AGWDRKNACL IEPQPMQLVC
AMPVIHFKPQ EVLKKKTRGL YSCPCYYFPI RTGAPNRPAF VVAVDLKSGA ENADFWIKRG
TALLLSLSN
//
