ID A0A139WEF9_TRICA Unreviewed; 8149 AA.
AC A0A139WEF9;
DT 11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT 11-MAY-2016, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=Microtubule-actin cross-linking factor 1 {ECO:0008006|Google:ProtNLM};
GN Name=AUGUSTUS-3.0.2_33680 {ECO:0000313|EMBL:KYB26247.1};
GN ORFNames=TcasGA2_TC033680 {ECO:0000313|EMBL:KYB26247.1};
OS Tribolium castaneum (Red flour beetle).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Tenebrionidae; Tenebrionidae incertae sedis; Tribolium.
OX NCBI_TaxID=7070 {ECO:0000313|EMBL:KYB26247.1, ECO:0000313|Proteomes:UP000007266};
RN [1] {ECO:0000313|EMBL:KYB26247.1, ECO:0000313|Proteomes:UP000007266}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Georgia GA2 {ECO:0000313|EMBL:KYB26247.1,
RC ECO:0000313|Proteomes:UP000007266};
RX PubMed=18362917; DOI=10.1038/nature06784;
RG Tribolium Genome Sequencing Consortium;
RA Richards S., Gibbs R.A., Weinstock G.M., Brown S.J., Denell R.,
RA Beeman R.W., Gibbs R., Beeman R.W., Brown S.J., Bucher G., Friedrich M.,
RA Grimmelikhuijzen C.J., Klingler M., Lorenzen M., Richards S., Roth S.,
RA Schroder R., Tautz D., Zdobnov E.M., Muzny D., Gibbs R.A., Weinstock G.M.,
RA Attaway T., Bell S., Buhay C.J., Chandrabose M.N., Chavez D.,
RA Clerk-Blankenburg K.P., Cree A., Dao M., Davis C., Chacko J., Dinh H.,
RA Dugan-Rocha S., Fowler G., Garner T.T., Garnes J., Gnirke A., Hawes A.,
RA Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N., Joshi V.,
RA Khan Z.M., Jackson L., Kovar C., Kowis A., Lee S., Lewis L.R., Margolis J.,
RA Morgan M., Nazareth L.V., Nguyen N., Okwuonu G., Parker D., Richards S.,
RA Ruiz S.J., Santibanez J., Savard J., Scherer S.E., Schneider B.,
RA Sodergren E., Tautz D., Vattahil S., Villasana D., White C.S., Wright R.,
RA Park Y., Beeman R.W., Lord J., Oppert B., Lorenzen M., Brown S., Wang L.,
RA Savard J., Tautz D., Richards S., Weinstock G., Gibbs R.A., Liu Y.,
RA Worley K., Weinstock G., Elsik C.G., Reese J.T., Elhaik E., Landan G.,
RA Graur D., Arensburger P., Atkinson P., Beeman R.W., Beidler J., Brown S.J.,
RA Demuth J.P., Drury D.W., Du Y.Z., Fujiwara H., Lorenzen M., Maselli V.,
RA Osanai M., Park Y., Robertson H.M., Tu Z., Wang J.J., Wang S., Richards S.,
RA Song H., Zhang L., Sodergren E., Werner D., Stanke M., Morgenstern B.,
RA Solovyev V., Kosarev P., Brown G., Chen H.C., Ermolaeva O., Hlavina W.,
RA Kapustin Y., Kiryutin B., Kitts P., Maglott D., Pruitt K., Sapojnikov V.,
RA Souvorov A., Mackey A.J., Waterhouse R.M., Wyder S., Zdobnov E.M.,
RA Zdobnov E.M., Wyder S., Kriventseva E.V., Kadowaki T., Bork P., Aranda M.,
RA Bao R., Beermann A., Berns N., Bolognesi R., Bonneton F., Bopp D.,
RA Brown S.J., Bucher G., Butts T., Chaumot A., Denell R.E., Ferrier D.E.,
RA Friedrich M., Gordon C.M., Jindra M., Klingler M., Lan Q., Lattorff H.M.,
RA Laudet V., von Levetsow C., Liu Z., Lutz R., Lynch J.A., da Fonseca R.N.,
RA Posnien N., Reuter R., Roth S., Savard J., Schinko J.B., Schmitt C.,
RA Schoppmeier M., Schroder R., Shippy T.D., Simonnet F., Marques-Souza H.,
RA Tautz D., Tomoyasu Y., Trauner J., Van der Zee M., Vervoort M.,
RA Wittkopp N., Wimmer E.A., Yang X., Jones A.K., Sattelle D.B., Ebert P.R.,
RA Nelson D., Scott J.G., Beeman R.W., Muthukrishnan S., Kramer K.J.,
RA Arakane Y., Beeman R.W., Zhu Q., Hogenkamp D., Dixit R., Oppert B.,
RA Jiang H., Zou Z., Marshall J., Elpidina E., Vinokurov K., Oppert C.,
RA Zou Z., Evans J., Lu Z., Zhao P., Sumathipala N., Altincicek B.,
RA Vilcinskas A., Williams M., Hultmark D., Hetru C., Jiang H.,
RA Grimmelikhuijzen C.J., Hauser F., Cazzamali G., Williamson M., Park Y.,
RA Li B., Tanaka Y., Predel R., Neupert S., Schachtner J., Verleyen P.,
RA Raible F., Bork P., Friedrich M., Walden K.K., Robertson H.M., Angeli S.,
RA Foret S., Bucher G., Schuetz S., Maleszka R., Wimmer E.A., Beeman R.W.,
RA Lorenzen M., Tomoyasu Y., Miller S.C., Grossmann D., Bucher G.;
RT "The genome of the model beetle and pest Tribolium castaneum.";
RL Nature 452:949-955(2008).
RN [2] {ECO:0000313|EMBL:KYB26247.1, ECO:0000313|Proteomes:UP000007266}
RP GENOME REANNOTATION.
RC STRAIN=Georgia GA2 {ECO:0000313|EMBL:KYB26247.1,
RC ECO:0000313|Proteomes:UP000007266};
RX PubMed=19820115; DOI=10.1093/nar/gkp807;
RA Kim H.S., Murphy T., Xia J., Caragea D., Park Y., Beeman R.W.,
RA Lorenzen M.D., Butcher S., Manak J.R., Brown S.J.;
RT "BeetleBase in 2010: revisions to provide comprehensive genomic information
RT for Tribolium castaneum.";
RL Nucleic Acids Res. 38:D437-D442(2010).
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DR EMBL; KQ971354; KYB26247.1; -; Genomic_DNA.
DR EnsemblMetazoa; TC033680_003; TC033680_003; TC033680.
DR Proteomes; UP000007266; Linkage group 7.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0045104; P:intermediate filament cytoskeleton organization; IEA:InterPro.
DR CDD; cd21188; CH_PLEC-like_rpt1; 1.
DR CDD; cd21189; CH_PLEC-like_rpt2; 1.
DR CDD; cd00176; SPEC; 17.
DR Gene3D; 1.20.58.60; -; 30.
DR Gene3D; 3.30.160.780; -; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 3.30.920.20; Gas2-like domain; 1.
DR Gene3D; 3.90.1290.10; Plakin repeat; 15.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR041615; Desmoplakin_SH3.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR003108; GAR_dom.
DR InterPro; IPR036534; GAR_dom_sf.
DR InterPro; IPR049538; PCN-like_spectrin-like_rpt.
DR InterPro; IPR043197; Plakin.
DR InterPro; IPR035915; Plakin_repeat_sf.
DR InterPro; IPR001101; Plectin_repeat.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR23169; ENVOPLAKIN; 1.
DR PANTHER; PTHR23169:SF23; SHORT STOP, ISOFORM H; 1.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF02187; GAS2; 1.
DR Pfam; PF00681; Plectin; 1.
DR Pfam; PF17902; SH3_10; 1.
DR Pfam; PF00435; Spectrin; 20.
DR Pfam; PF21020; Spectrin_4; 1.
DR SMART; SM00033; CH; 2.
DR SMART; SM00243; GAS2; 1.
DR SMART; SM00250; PLEC; 31.
DR SMART; SM00150; SPEC; 37.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF143575; GAS2 domain-like; 1.
DR SUPFAM; SSF75399; Plakin repeat; 20.
DR SUPFAM; SSF46966; Spectrin repeat; 31.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
DR PROSITE; PS51460; GAR; 1.
PE 4: Predicted;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000007266};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 39..142
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 291..396
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 7963..7998
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 7999..8034
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 8039..8111
FT /note="GAR"
FT /evidence="ECO:0000259|PROSITE:PS51460"
FT REGION 3083..3110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5156..5217
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 7808..7905
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1082..1176
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 4539..4566
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 4604..4659
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 5283..5310
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 5544..5578
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 5646..5673
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 5761..5816
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 6091..6118
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 7682..7709
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 5169..5217
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7808..7849
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 8149 AA; 925189 MW; 890EEA349922DF9F CRC64;
MDFDKDPTLQ EWTREQPLSV LALDSADRAV LRIADERDAV QKKTFTKWVN KHLKKANRQV
RDLFEDLRDG HNLISLLEVL TGEQLPREKG NMRFHMLHNI DTALHFLHCK KIKLVNIRSE
DIVDGNPKLT LGLIWTIILK FQCNAIMSMY RFVKDGHAGG QKRLFVQGTS GESSRVLGPP
IVTRFSDPNE MDNLQAVYTK KRLSTEVLGS SIESTKTSRR AEDGTRRITT RIVRKVTTLT
RGEEKSTAED LTKRAVTRSI QSREDVAKQT EAVQPKRVKI SDIVVGQEPN VSAKDYLLRW
AKRTTHKYPG VHVQDFTKSW RDGLAFSAII HRNRPDLIDW RSVKTQRASE RMETAFYIAE
REYGVTRLLD PEDVDTHEPD EKSLITYISS LHEVFPEPPA IHPLYDSGAQ QRVYEYRELA
SSLHIWMREK YTLMTDRSFP NTLIEMKKIA TELSRFRTDE LPPRQRDKNY LSQLFRDLEK
YFKTIGEVDV EPELHIDNIE RNWQRLMGAY QERDRHVQDE IKRLEKLQRL AEKVHREIKQ
TDSGLDTIER TIGNESRRIE RMHPLEAKKI ADQLDQDLAN AEASIQGLTT DVNTLRNGRY
PQAGELDKRV KNLHERWVHL RRLLHNKIVG PLSNLSFPVE ERTVTKHIRT VQETRNVDTN
PHFRSLQEYI EWCKNKLKQL KKADYGNDLQ SVQAERNFHQ HEHKQIDQFH SKVESCAKAR
QYFTGEELAL YNQHLGQLQK VYADLLSFST NRMTDLDTLY DFIQSATTEL QWLNEKEEVE
VTRDWSDVKM NVASVETYYE NLMSKLEKRE DQFNSVQERG EFLIQQQNHP ASKAIEAHIA
AMQAQWAWII QLSHCLETHL QNTRNYQQFF KDVQTAEEWL KEKDDVMNNE FSQGDFSLDT
GEKLLQGMQL LKDELNSFGD QVQTLIARSQ EIVPLKQRRQ PVTRPLTVIA ISNYKQNNFV
IEQNKECTLT DNSGRIKWRV HNEKGIEAQV PGVCFVIPPP DKDAIDAAER LRRQYDRSIA
LWQKKQLRLR QNMIFATIKV VKGWDLPQFI AIGAEQRNAI RRALNEDADK IMAEGDPSDP
QLRRLKREMD EVNRLFDEFE KRARAEEESK NQTRIFNQQI SNLQQALDEA ERIINKRVIA
HLPRDIDTLQ HLVLEHKEFE SRLQNLEPEI EQVKDTFRSI TLKTPQHKKD LEKVLDKWKY
IWNTSNLYIE RLKCIEIVLN GMEDATLVIS EFESKLALFH ELPSSEKGLE GVHEDLLKLQ
SAIGQQQIAM DQLNDDFDNT RRLTEKSRPN QRGPHTDIER LDKEIQKLNA RWSNVCSQLA
DRLRGCEQAY NLLKNYKKPK ENEDAWLDEH YGKLENLQPI KDRAKEHLEA TRNLLNSVYE
RAPVIEQVNV NGGRFIREGK IWSKGLQRFR EALLETQPSL DVVFRAAKES GPTGADIIAK
ELDEFNARYQ YLIDELYRRL QEIAARCPGD IVTLRLVEQM QPRPFRTFRS EFHMSSASEQ
TATYTTTTHL STQYIHQKPI LTENGTTVSI TTDSLNQSLD ERDKISNGRP PDKYTTKTQI
IHESQNWGKS MHFTEIKSLK RVHKVHEGIG TESITDTPGI VNPYNGELIT VREAIAARIL
DGRTGKIVIS PDGTQVSIEE ARKRQLIDPK IAEGLISPCG IIEDGRELTL LEAIQRKIYE
AEHGFVDPSE KRIKVTHSST INQAIDDGKV DVNTGTFRLE SGETIDIKEA YKRGYLLQHT
EVKLQTGAMA LSDAITQGLI DDRTGWIVDR NSGSKYQIDA AVKTNVIDGD IREIVDPRSD
DKLTVIQAIE QGLINPKIGK YVYFHEKFSY LEAKRRQLIV KPKTLKEVVD DGLMDDSGKI
LSPTHQTRLT ILEAVARGVL DVDTIKSILD FQKNELVTLG DALKDGIITP DGKFQNSVTG
EIMTIQEAVS RGYIISVVKK SIFDVDAFQP PDKSDHISYN AANAKGYISK KSNGSLLVNS
KSGKLIPFSE GVETGEVKPE VYEMLTRKIG IFENQKELTV LEAVFRGYID PKTGNLIDIT
RNEIVYLNEA IAQHLITPEG AAMLNSLLNL NVSTQVTRTL VQRYVTVTQK DLKSTQLTYS
QALRQGLIDN ESQTFRDPET NQVIPIVQAI SDGKLAPDSE SSSQVVSTGA VPRKSTVVTI
TSRKEIPVTK FDVQTATTDL LTSERNLGEK QVYELPTEGW ALQDAINQKL FDPVTGLFII
PGTDRLTSLK ECITLKIINP NSAVVIDPSN QRKVSLVKSL SKKILDDTGH YNSGSDKITM
KEAISKELIL FESEMEVETN SQRLLQITKL DGKPDKIEVS NVLDNYPPTY TEVKTSETKD
AQPVEVAPGV IYDPANALVV CPQTKQASPL LTAIQEKTIP ATSITVKDPH TGKDLPIEEA
IRRNIVDKNT GEYTNKSGHK ISLGDAAKYG IIAVVGAPLA ATYSIAKAVK TFVVDPKSGE
KVPVDEALQR GVIDQHQYSK LQSQALVDSE KSGAFDDEGP SEAEKTRARI TVEPTYKVTI
GRVQSLSPDR DAKKVVLQKL RRKVVKPRDA AEKGMIDKDT AQLLDKKDTF TSPSGDSLTL
QEALDSKKVD GDKGKIIDPQ RGDELTINEA IARGILDPDG TNQLLVPLNR SLSIPELFHQ
GLIDPDSQKV VHPETGAHLS IREAIVCDIV DPLSTLTEKT GAKVTLEQAI DSGVVNDAKS
TVRTRKGSVD LQKAVNDKVF DDSVPSGPEK LPMAGMTFPV ALKRGLVDPN KKEITHPITK
ERIPIKDAID DEFIMSVPFP TSPEAIKVED ALECKLIDPK TGTFKDPKSG EMLPVAEAVE
KGLLVIKDYP IGISSQPVTT VTETVNTIHT VTTRTIELLS GYALVSATEV LNTQTGEIIP
FEEARKRGII TNDEETKNTT TVKDVMSFSD ALNRGLVDMN AGTFTDPKSG EKILIKEALQ
EGKLLATSTE DTSSVQTTEM NIAQAFDTIY DEKTAKFHDP SNPQKSLTFE EAIKKEIIDP
NSVVYDVTSQ KPITVEQAVE KGLIDSKTGK VHDQKSGKSI DFKEATKKGL IAVLGGLAMP
VVAPVLAGAA AVKAVKKYAD EKKAKQEPVG QKVETTKEEP PRQKVEITRE DPPRQKVEIT
IIKKVDEEEV KTKKSVVEDQ VEEIEEIALR LPLSEAIEEG RIVPDKCRVV HNDKQLPYSV
AEGLKLNKLY PGDIVQIVNK HSVIFIESSV SILVISKDVT PQKLVELGYY DLKSRRFIDP
RTGEFITFET FLYELELFNP DAILVKDLTS KPPVYVTLEE ALNRPLIDKN TGYMVDPKTG
KRVPFFEAVK LRWIIDIKDK PKQKYQPLTL EEIVETDKFD PVKVEVKSND EIIPLSKALT
SNIIDPKSVT IRDEKNMQLV PYYEAVDRSI VDPQRALVLN TATQKTMTYS EAFLHGFVRA
LPRPITLEAI IYKGLYDPQT ATITDPITKQ SLIIAEAVDR QIIDDKLSEV KDTKRGTFVP
LDEALKTNLV QDGRLKDTKT GQLVPLSVAL DQHLIRSKPI VFNLLQALLS NYYLSRSGTI
LNPITGEEIT LQKAIEYKLV DPVTTRIKDN KRGRIVELRE AIQTNLVDPE KGILTEPALP
LDQAYLKGYI LSTVLPWSLQ ETLAQKVYDP KTGQFTVNNA NVTLVQAIEG GIVNPNVLTV
KDPRSGDIIT LNDAISLRII DPVKGQAYDP LTSTEMNLYD AQDRGLIVPY KSQITLPEAV
FKGFYDPTTG KFINPKSKER LRAESAINRG YVDTSSTLVT IDEELVTFEQ AVVEGYIDTI
EGVVISSRHE PVDFNEAFER GLLVEVGPPI PLSEAIAKGL YDEESQLFLD PQTGNYVTLI
EAIEINLIDA DSVSVKDTRV GVWRKIPLID AIHNGYVDGN TGNVKDFSQG ESCEVPLQKA
FHLGILVDNK AAVSLQRAIH QGLYHEATGK IIDPHTDRKI TLHEAIRKFI INPLLPVYFD
KKRGKLVNLT DTCRLGIVDK RNGTFKDPHT EETMKLTEAL DKGLIVDIET ANFGLYEAID
MGLYDPDDGM FIHPSTCRKF TLKDACNNEL INPEMSLVKN SKQNKYIFLP EAIEKQLVDP
ELGKFILPNG NSITLLEAKR KGLIVTVRRN LTLEEAIRNG LYRPDSGKFA DPLNGEFYDL
TQALANNFID PTTTAFKDPF NGTIKSLPLA IQDGKIDTDK GRVLDTKSKQ TYNFDVALDK
GLLVTLDKPL VEEVMQKSVT DSSKASKTAR ECTLEAAIKF ELIDPNRAVV KDLQTGRFKT
VQDAIDAKIL DINKSVTFEP QKDKVKSRIV TYDQTTPIYL DEPLTFLQAI ESNHLDVTTG
KFTDPQTKEV LSLKDSLSLG FIDPDTALIK DGNKKKLIKL PEGFRKGLID ADKGNVLDSS
TSKLYPLPTA IDTGLLITPS RGFTLIEALI YGLYNPTTGG FTCPFTITSI IDRKRLTLTE
AIDDNLIDPS STVVKDPESG GVVPLLHAID SKIVNAVDGR IRDDDKEIDF IKGHEKGLIL
PAEQRQAVEE KYKLCDETLS KLLQWIGDVE DKIASQDVIH EVEEDLRNKI NTMKQIRDDL
DQHSSQVAHC GDQVRQLVLT AGDVLSKSEV STLEKNGRNL KTRYDKAVDR SERLLRKLLS
AKDELTKLKG ELNTFSDWLG KARRILEDKE RALSDLQRLD SSADSTKEFV SDVIAHQGDL
RFINMSAQKF FDESKEYLAL LNDFRTSLPS RLHHIEPIAA QDSPVRTEVS LVGQQYRDLL
NRANNLSDRL SGVGGRQREY SDAVDKARQW LREAEPRAIK ILDEPIGGDP KAVEEQLHRA
KSLNNEFVAN GRLIDNAKQA TDALLNSLQG QISPAEMSRL EQPVIELDQK YNQLSNALAD
RCQELDTALV QSQGVQDALD GIMNWLNTAE SQFKTMQKPA SLIKERLDEQ LREHRVFQSD
IDTHISSIDS VYLSASELIA SSSNARVAKK IETKLNDVKA RFEKLFERAQ KRGEFLEEVN
KGLTAFLAGA SQFEQWHASI VEIIESRELA KLSIEEYAVR MQEIAANRDD KRPLFEEVIK
CGKDLLNKRD TTDTANVRDR VKSMENQWRE LGSLLDEKQK LSKQRAEQLN AYEALRQQVC
DWLSRFEARI ARLEVVAIDI EILKKQNEEL KPITKEYKDY SSTIDKVNDI GTAYDNLVRG
DRPESPSKRR NQVYSPTKRT YRPTQDTRSP SPSKGLSPLS PGGSSGFSSR RSSQDGFHLE
ELSPVQQQLS EINHRYSLLG VKINDRQSEI DSIRDEVKKH LDSLKTLSAF LDKVQRQLPK
DIVPATKDEA DKLNRQIKQA LEEMYEKQSL LDSTKSQVKD LLRRKPGALG ADNLNDELED
VVSHWKSVSD HLKNRIKFME DMKEFHDTHD SLSSWLSAKD RMLTVLGPIS SDSRMVQSQV
QQVQVLREEF RTQQPQLQHL IDVGDSVLSY LDPRSPDGQK VNNKLANIQQ RWADLLSKLE
ERADSLGAAA DTSREFDAQL TRLRDALQGI SDNLDELPLD KDPEEQLRKV ENLERQLEGQ
RPLLADLEAA GSQLCDVLSD PASRADIQAK LASVGRQYNA LQKKLDHKKA EIEGSLRDGR
QFEASCAKTL GWLSDELGSL SEKLLISAIR DVLEQQLAHH EPIYRDVLAR EHEVIMLLNK
GRDMLARNNR SDSRSLQRDL DKIQQQWEKL RKETVDRQTR LQTCKEHCRK YYKVLESFLP
WLRQAEDKLD TLRPSSFQRK HIEKQLKELQ AFRNEVWKKS GEYENTRTLG DTFVSACDID
KEVVKNELND LKERWDKLNN DLIERTQALE DQSRKLADFN ENIRELQHGV ERCEDKLASH
DALGGAARDP KLLERIKALR EETAKLRKPL QTVKQQAQDL ASEAAQNGID AHHLEDEVDS
LGDRIDELTS KLDDRCSELQ SAATAVTQFN EQVKGLSHDL TGLETELDEM KPPGRDLKTV
RGQIDDIGRF LVKINKATDD VNDAIAAGER LVDSGFAPDT AQTRQQVETL RKQLGKLDDR
ARSREQSLED IHKKLEQFYM SHANVLDDIH DASEQLRKLK AVGSEVDSIR AQQQDFKKFR
AKTVEPVGKA VENCNRVGQG LIQSAAPGVN TAILEKDLEK MNEQWNDLKE RLNDRERRLD
VALLQSGKFQ EALDGLAKWL TDTEELVANQ KPPSADYKVV KAQLQEQKFL KKMLLDRQNS
MSSLFSMGNE IAKEAEPAER KAIEKQLKNL MGRFDALTEG AQQRTLDLEQ AMKVAKEFQD
KLIPLQDWLD RSEKKVKDME IIPTDEEKIQ QKIREHGALH NDILGKKPDF RELTDIASNL
MSLVGEDEAA TLADKLQEVT DRYGNLVDAS ERIGQLLTDS RQGLRHLVLT YQDLAAWMDS
MEHRLGRFKV LAVHTDKLLE QMDDLTALTE EIASRQQDVD STVDAGVELM RHISSDEALQ
LKDKLDSLQR RYNDLTSRGA DLLKHADDML PLVKQFHNNH NRLVDWMQGA ESVLQSAEPH
EGDIARLELD LQELRPVLEH INLLGPQLCQ NSPGEGASTI EGLVTRDNRR FDAIAEQIQR
RAERIHLGKQ RALEVTGDID ELLEWFREVE SQIRDAEKPS AEPDLIRVQL KEHKALNDDI
SSQKGRVRDV LSTAKKVLRE SPPSEDTSLI REKMEDLRET MDTVSALSSD RLGILEQALP
LAEHFHDTHN VLSNWLSDIE EQISMLAMPA MRPDLIAQQQ DRNEMFIQSI NDHKPLVDKL
NKTGEALIRL CNDDDGSKVQ ELLDSDNARY AALKLELRER QQALEQALQE SSQFSDKLEG
MLRALSNTAD QVNNLEPISA HVPKIKDQIE DNDALISDLD KRKEAYAAVQ RAADDVINKA
PNRSDPAIKD IKRKLDKLKN LWDDVQKATN NRGRSLDDTL DAAQKFWKEL HAIMATLKDL
EDSLVSQEPP AVEPKAIQQQ QVALQEIRHE IDQTKPEVDQ VRASGKDLMR LCGEPDKPEV
KKHIEDLDNA WDNITALYAK REENLIDAME KAMEFHETLQ NLLAFLDKAE KKFAKMGPLG
TDIDAVKKQI DQLKNFKAEV DPHMVKVEAL NRQAQELTER TSADQAAAIK EPLSGVNKRW
DDLLRGIVER QRQLENALLR LGQFQHALNE LLVWISKTDK TLDELKPVQG DPQILEIELA
KLKVLVNDIQ AHQTSVDTLN DAGRQIIETG EGSDEASITQ DKLNTLNTQW RALMQKAADR
QRELEDSLNE AQRFNAEIQD LLSWLCDVDG IITASKPVGG LPETASEQLE RFMEIYNEIE
DNRPKVETVL AQGQEYLRKG SNAASNLQHN LRTLKQRWDS VTSRANDKKI KLEIALKEAT
EFHEALENFV EWLTNAEKIL SNLKPVSRVL ETIQGQMEEH KIFQKDVSAH REIMLDLDKK
GTHLKYFSQK QDVILIKNLL VSVQHRWERV ASKSAERTRA LDLGYKEAKE FHDGWSGLMT
WLNETEDSLD RLLSESVGND PEAIKSRLHK HQEFQRNLSA KQGTYDHVMK TGKVLKEKAP
KSDEPTIRQM MSDLKAKWTA VCNKSVDRQR KLEEALLYSG QFKDAIAALL QWLKKVEKEL
SVDSPVHGDL DTVNHLVDLH NQFEKELERR NEQMESVIRT GTDLERKANR ADATQIRSQL
TELNELWNSV TKLTRIRSGR LDEALHEAER LHKSVHMLLD WLSEAERQLR FVGSTPEDEA
TAYEQLQALD RFRAELKDKE REKNHTLDLA QSVLAKAHPD AINVIKNWIK VIQSRWEEVS
QWAMQRHQKL TAHMQSLRDL DECLEELIQW LLGLENTLIA LKREDLPMDI PATEQLIADH
KEFMENTQKR QGEVDRVCKA KQIKPTNAKE PKKFVKGKGP IRGSQHDIRE PSPDSYGSLG
RKQSFKGSRD LLAHRGSRSS PGRELSPDPQ LPHIGPRFPS GSEPEFRSPR VKFLYDKWRH
VWMLSWERQR QLYDHLAYLK EKEKADNFSW DDWRKRFLKF MNYKKSRLTD LFRKMDKDNN
ELIPRDDFID GIIKTKFDTS RLEMKHVADM FDQDNRGLID WKKFIAALRP DWEEKPADTD
AQKIHDEVKR LVMLCTCRQK FRVFQVGEGK YRFGESQKLR LVRILRSTVM VRVGGGWVAL
DEFLIKNDPC RGECLPITKP KKIYIKILSK QNYTSLITML CPLLRHTSY
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