ID A0A139WI03_TRICA Unreviewed; 4086 AA.
AC A0A139WI03;
DT 11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT 11-MAY-2016, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Dynein heavy chain, cytoplasmic-like Protein {ECO:0000313|EMBL:KYB27407.1};
GN Name=AUGUSTUS-3.0.2_14710 {ECO:0000313|EMBL:KYB27407.1};
GN ORFNames=TcasGA2_TC014710 {ECO:0000313|EMBL:KYB27407.1};
OS Tribolium castaneum (Red flour beetle).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Tenebrionidae; Tenebrionidae incertae sedis; Tribolium.
OX NCBI_TaxID=7070 {ECO:0000313|EMBL:KYB27407.1, ECO:0000313|Proteomes:UP000007266};
RN [1] {ECO:0000313|EMBL:KYB27407.1, ECO:0000313|Proteomes:UP000007266}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Georgia GA2 {ECO:0000313|EMBL:KYB27407.1,
RC ECO:0000313|Proteomes:UP000007266};
RX PubMed=18362917; DOI=10.1038/nature06784;
RG Tribolium Genome Sequencing Consortium;
RA Richards S., Gibbs R.A., Weinstock G.M., Brown S.J., Denell R.,
RA Beeman R.W., Gibbs R., Beeman R.W., Brown S.J., Bucher G., Friedrich M.,
RA Grimmelikhuijzen C.J., Klingler M., Lorenzen M., Richards S., Roth S.,
RA Schroder R., Tautz D., Zdobnov E.M., Muzny D., Gibbs R.A., Weinstock G.M.,
RA Attaway T., Bell S., Buhay C.J., Chandrabose M.N., Chavez D.,
RA Clerk-Blankenburg K.P., Cree A., Dao M., Davis C., Chacko J., Dinh H.,
RA Dugan-Rocha S., Fowler G., Garner T.T., Garnes J., Gnirke A., Hawes A.,
RA Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N., Joshi V.,
RA Khan Z.M., Jackson L., Kovar C., Kowis A., Lee S., Lewis L.R., Margolis J.,
RA Morgan M., Nazareth L.V., Nguyen N., Okwuonu G., Parker D., Richards S.,
RA Ruiz S.J., Santibanez J., Savard J., Scherer S.E., Schneider B.,
RA Sodergren E., Tautz D., Vattahil S., Villasana D., White C.S., Wright R.,
RA Park Y., Beeman R.W., Lord J., Oppert B., Lorenzen M., Brown S., Wang L.,
RA Savard J., Tautz D., Richards S., Weinstock G., Gibbs R.A., Liu Y.,
RA Worley K., Weinstock G., Elsik C.G., Reese J.T., Elhaik E., Landan G.,
RA Graur D., Arensburger P., Atkinson P., Beeman R.W., Beidler J., Brown S.J.,
RA Demuth J.P., Drury D.W., Du Y.Z., Fujiwara H., Lorenzen M., Maselli V.,
RA Osanai M., Park Y., Robertson H.M., Tu Z., Wang J.J., Wang S., Richards S.,
RA Song H., Zhang L., Sodergren E., Werner D., Stanke M., Morgenstern B.,
RA Solovyev V., Kosarev P., Brown G., Chen H.C., Ermolaeva O., Hlavina W.,
RA Kapustin Y., Kiryutin B., Kitts P., Maglott D., Pruitt K., Sapojnikov V.,
RA Souvorov A., Mackey A.J., Waterhouse R.M., Wyder S., Zdobnov E.M.,
RA Zdobnov E.M., Wyder S., Kriventseva E.V., Kadowaki T., Bork P., Aranda M.,
RA Bao R., Beermann A., Berns N., Bolognesi R., Bonneton F., Bopp D.,
RA Brown S.J., Bucher G., Butts T., Chaumot A., Denell R.E., Ferrier D.E.,
RA Friedrich M., Gordon C.M., Jindra M., Klingler M., Lan Q., Lattorff H.M.,
RA Laudet V., von Levetsow C., Liu Z., Lutz R., Lynch J.A., da Fonseca R.N.,
RA Posnien N., Reuter R., Roth S., Savard J., Schinko J.B., Schmitt C.,
RA Schoppmeier M., Schroder R., Shippy T.D., Simonnet F., Marques-Souza H.,
RA Tautz D., Tomoyasu Y., Trauner J., Van der Zee M., Vervoort M.,
RA Wittkopp N., Wimmer E.A., Yang X., Jones A.K., Sattelle D.B., Ebert P.R.,
RA Nelson D., Scott J.G., Beeman R.W., Muthukrishnan S., Kramer K.J.,
RA Arakane Y., Beeman R.W., Zhu Q., Hogenkamp D., Dixit R., Oppert B.,
RA Jiang H., Zou Z., Marshall J., Elpidina E., Vinokurov K., Oppert C.,
RA Zou Z., Evans J., Lu Z., Zhao P., Sumathipala N., Altincicek B.,
RA Vilcinskas A., Williams M., Hultmark D., Hetru C., Jiang H.,
RA Grimmelikhuijzen C.J., Hauser F., Cazzamali G., Williamson M., Park Y.,
RA Li B., Tanaka Y., Predel R., Neupert S., Schachtner J., Verleyen P.,
RA Raible F., Bork P., Friedrich M., Walden K.K., Robertson H.M., Angeli S.,
RA Foret S., Bucher G., Schuetz S., Maleszka R., Wimmer E.A., Beeman R.W.,
RA Lorenzen M., Tomoyasu Y., Miller S.C., Grossmann D., Bucher G.;
RT "The genome of the model beetle and pest Tribolium castaneum.";
RL Nature 452:949-955(2008).
RN [2] {ECO:0000313|EMBL:KYB27407.1, ECO:0000313|Proteomes:UP000007266}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Georgia GA2 {ECO:0000313|EMBL:KYB27407.1,
RC ECO:0000313|Proteomes:UP000007266};
RX PubMed=19820115; DOI=10.1093/nar/gkp807;
RA Kim H.S., Murphy T., Xia J., Caragea D., Park Y., Beeman R.W.,
RA Lorenzen M.D., Butcher S., Manak J.R., Brown S.J.;
RT "BeetleBase in 2010: revisions to provide comprehensive genomic information
RT for Tribolium castaneum.";
RL Nucleic Acids Res. 38:D437-D442(2010).
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR EMBL; KQ971343; KYB27407.1; -; Genomic_DNA.
DR STRING; 7070.A0A139WI03; -.
DR EnsemblMetazoa; TC014710_002; TC014710_002; TC014710.
DR InParanoid; A0A139WI03; -.
DR OMA; GRDIPCS; -.
DR Proteomes; UP000007266; Linkage group 5.
DR GO; GO:0005929; C:cilium; IEA:UniProtKB-KW.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46961; DYNEIN HEAVY CHAIN 1, AXONEMAL-LIKE PROTEIN; 1.
DR PANTHER; PTHR46961:SF9; DYNEIN HEAVY CHAIN, CYTOPLASMIC-LIKE PROTEIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR PROSITE; PS00978; FAD_G3PDH_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000007266}.
FT DOMAIN 716..1121
FT /note="Dynein heavy chain linker"
FT /evidence="ECO:0000259|Pfam:PF08393"
FT DOMAIN 1249..1575
FT /note="Dynein heavy chain hydrolytic ATP-binding dynein
FT motor region"
FT /evidence="ECO:0000259|Pfam:PF12774"
FT DOMAIN 1743..1891
FT /note="Dynein heavy chain AAA 5 extension"
FT /evidence="ECO:0000259|Pfam:PF17852"
FT DOMAIN 2114..2209
FT /note="Dynein heavy chain 3 AAA+ lid"
FT /evidence="ECO:0000259|Pfam:PF17857"
FT DOMAIN 2270..2531
FT /note="Dynein heavy chain AAA module D4"
FT /evidence="ECO:0000259|Pfam:PF12780"
FT DOMAIN 2546..2890
FT /note="Dynein heavy chain coiled coil stalk"
FT /evidence="ECO:0000259|Pfam:PF12777"
FT DOMAIN 2919..3140
FT /note="Dynein heavy chain ATP-binding dynein motor region"
FT /evidence="ECO:0000259|Pfam:PF12781"
FT DOMAIN 3384..3498
FT /note="Dynein heavy chain region D6 P-loop"
FT /evidence="ECO:0000259|Pfam:PF03028"
FT DOMAIN 3533..3672
FT /note="Dynein heavy chain AAA lid"
FT /evidence="ECO:0000259|Pfam:PF18198"
FT DOMAIN 3678..3988
FT /note="Dynein heavy chain C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18199"
FT COILED 73..110
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2789..2823
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4086 AA; 468509 MW; E3CB38243A95C2ED CRC64;
MGSRGRDIER ERLLKRIAEK RARLEARGDL NIKVPRLTVP SDFNIQDRNV FSLPPEILRP
VIASSYPKYR KKVAEQKKRD EELKNKLKSY TELRKQREEF RKRLVDLIVN KDDDAEVDPN
QIPSADEREI LRYYYYIKYG VDTIHVAPLD IKVLNRVLAL VPRKLMKWEQ TLEASIEDMK
TDFMMAVKKA IVDFVLQDPA FVKVVAEKES PHKKELKDMV LTVKNVIQTA KAKLERDLHV
INPCLAAILD IWYSRFRKLR LVDTKELMAH EGAFSLEEFK WTINNQIDAC KQTLMNDYYA
AVTDVFLQGS KRNLLPDPAK PKRMKSFYNA VATIMTYNLQ TLCLKSLYDY ISYITDIKYS
NKGFIIHLHQ KVNTLVFEPP FKHFTDALLN VIDFIIEAVM TVPRLECRLY LDAGQEVYLK
PTIPELTVGN YRQQIRDLLE NQRIGPELRV QDFDEYMPLI NGEDEEWINQ FLAEDRSFDE
YVEEILRYKQ IIDEIPIVKE HVITMEMYDM ERFEMIKALV AAAENFKDIL IKRCTKDYQS
LCKALGEEYQ AIAEKSLKTP ANTAELMALI RFVEDTEATT LPEMEDRLRI VLKYMLFLSD
HAIFTPIEMK QNNITFLWYL RMPRVIEEHR QLVDVKMEEF QASLAARIQK FVDDLQLYAK
MVEELQHNGN IDDLPRYHKK ATQLDNRLIT AMEKIDAFNE EEAAFGFELS QYPLRKQTHD
KLTPYKKLYD NAMEFLTKYE LWMKSQVGTY DPEEIEQDVA QCYRNVYKLE KVFSDRPATQ
QLATTVRTQI EEFKEHMPII QTLGNPGMKP RHWEKISEIV GFPIKVDAEL TLEKIIDYGL
DEYIDKFEAI SEAATKENNL EKNLSKMMTE WQDMEFVVHA YRDTGTYILS AVDDIQVLLD
DHIVKTQTMK NSPYIKPFEK EILSWEAKLQ LLQEILDEWL KVQSTWMYLE PIFSSPDIQQ
QMPEEGRRFS AVDKIWRDLM KTVNADCRVL SVVEIDKMLE RLKKCNSLLE MIQRGLNDYL
EKKRLYFPRF FFLSNDELLE ILSETKDPTR VQPHLKKCFE GIAKLTFTED LDVTEMKSSE
GEVVPLVDVI QTALARGQVE KWLVELETDM KKSVHKMVHE AVKDYVKRVR EQWVLVWPGQ
TIQCISMTYW TLEVHKAIET GTQAMKTYLE KCTEQIGKIV DLVRGKLNAQ NRITLGALVV
LDVHARDVLA EIITLGVKNV TDFKWLCHLR YYWEENNLKT SMINSTLKYG YEYLGNTTRL
VVTPLTDRCY RTLFGALHLH LGGAPEGPAG TGKTETTKDL AKAVAKQCVV FNCSDGLDYI
ALGKFFKGLA SCGAWSCFDE FNRIDLEVLS VVAQQILTIQ RGINSGNEKL FFEGTELTLD
PTCAVFITMN PGYAGRSELP DNLKALFRSV AMMVPDYALI SEIELYASGF LTAKPLAVKI
VATYRLCSEQ LSSQCHYDYG MRAVKSVLRA AGALKLRYPD EQEDILVLRS IKDVNLAKFL
NMDVPLFQGI TSDLFPGVIL PEPDYVIMNQ AVDDACKTAN IQNTPFFLEK VQQLYEMIIV
RHGLMIVGLP FGGKTTSYRI LADALALIEE RGGMDEHRAI YTVMNPKSIT MGQLYGQFDP
VSHEWSDGVL AVSFRQFAMS TTDDRKWLIF DGPVDAVWIE NMNTVLDDNK KLCLMSGEII
QLANTTNLIF EPMDLEVASP ATVSRCGMIY MEPASLGWEP LLISWLNNLP AFINTDFYKT
MIKTLFVRFC KPLLWLLHKG GLKEIASTSQ TNLLRATMNL FDCFMDDYHD EKYREQVSDL
DVRAQIEGSF FFACIWSMGG TLDAASRPKF NLLFRALLER EFPEKVREEL HIPFEIAKPE
KPYIFTIPIG ETVFDYRYIK EGKGKWKLWS DELASAPPIP RDIPVNQIIV PTVETIRNIT
IMQLLVQHQK AMMIIGPTGT GKSCYVTDFL LKKNDTNTYK PVFISFSAQT TANQTQDIIM
AKLDKRRKGV FGPPVTKKCV IFVDDVNMPL KEVYGAQPPI ELLRQWFDHE MWYDRKEIVP
IKLVDIQFMC AMCPPTGGGN TITPRFSRHF NHLCIDEFQE NVLIHIFSKI MLWHLDTRGF
SKEFDPCIQQ IVLATLDIYK MARANLLPTP AKSHYLFNLR DFSRVIQGVL LSVPEAMEDL
VAMKRLWVHE VLRVYYDRLV DDADRSWIVE ALREVTSQQL EENFDTMFER LASAESSIIG
ETELRNLLYC DFANPKADQR HYIEVLDLEQ LKEIVEGYLA EFNNMTKKPM NLVLFRFAIE
HLSKLCRILK QPRSHGLCVG VGGSGRQSLT RLAAHISEYE LFQVEITRSY GVAEWREDVK
VILRKASATD QHGVFLFTDS QIKEEGFLED ISNLMNSGEV PNIFTGEERV ELCEKMRQLD
RQRDKSLQTD GSPVALYNFF VQIVKEQLHI VLAMSPIGDS FRTRIRKFPA IVNCCTIDWF
QAWPEDALLA VATRFLGEID LETRERDVCI DMCQMFHTTT QQLSDEYYTR LQRHNYVTPT
SYLELINTFK TFLNRKRQEV LTGKKRYEVG LEKLEHAGSQ VSVMQAALET LQPALVEAAA
KVSETLAKVE AESAEAAEVE KTVMADEAIA NEQAQKAQAI KDECDANLAE AMPILNAALA
ALNTLTTADI AVVKTMKSPP KGVRLVMEAV CILKDVKPEK LPLPSGIGTY EDYWGPSKKV
LGDMKFLDSL INYDKDNIPP KIMAKLAEKI LNDESFDPEK IKVASTAAEG LSKWVIAISK
YDKVAKVVAP KKLALAAAEA EFQTAMTALE IKRQQLRDAR EKVAKLEALL EAENKKFQNL
TDEVNLCTLK LHRAEELIGG LGGEKTRWMA TAKALGERYY MLTGDILIAA GVVAYLGPFT
LQFRNKQIEE WIHALIGFNI VCSKDFSLTA TLGEPVEIRA WNIFGLPTDS FSIDNGIIIK
NARRYALMID PQGQANKWIK NMEKSKNLAI IRLNQPDYVR ILENAIQFGQ PVLLENIGEE
LDPILEPVLA QQIFKQSGAL CLKLGDSVVE YNPDFRLFIT TKLRNPHYMP EVAVKVTLVN
FMITTVGLED QLLGITVAKE RPDLEAEKNA LILQGAENKR ALKEIEDKIL EVLSTSQGNI
LEDETAVQIL SSSKTLSNEI AAKQAIAEVT EQQIDKARME YKPIAVHSAI LFFTIVELAN
IDPMYQYSLV WFMNLFKAAI DNTEKVDDVV ERLADLEKYF TYSLYVNICR SLFEKDKLLF
SLLLAVNLLK SRDAIDLSEW MFLLTGGVGL DNPNVNPSDW LVTKSWDELC RLDEFPAFVG
IKDSFGQNLD KWKAMFDSVE PQDHPLPPPW DTKLSKFQKM LVLRCIRFDK VVPAIQEFVT
DNLGKKFIEP PPFDLYSSFT DSHCCIPLIF VLTPGADPTA VLLKFADDQG FGAARLFALS
LGQGQGPIAV KLIDEGIRNG TWVVLQNCHL AKSFMPTLER ICENLTPDST HPDFRLWLTS
YPADHFPVLV LQNGVKMTNE PPKGLRANII RSYLSDPISD PEWFESCTQS VPFKRLLYGL
CFFHASVQER RKFGPLGWNI PYEFNETDLR ISVMQLLMFL NEYEDIQYDA LLYLTGECNY
GGRVTDDWDR RCLSTILRKF YCKELVETPN YPFDPTKKYY CPDKEDYEEF MEYTKSLPLI
THPEVFGMNE NADIMKDQQE TNLMFSSILL TQDRTDAWKL KDALSTGGST KAPDDIVLEV
AADILAKLPK NYDRDAAMEK YPTLYAQSMN TVLVQEMNRF NRLLSEIRTS LINVGKAIKG
LIVMSPTLEE VTVSILTGRI PHLWMKKSYP SLKPLGSYVN DFLARLAFLQ KWYEEGAPST
YWLSGFFFTQ AFLTGAQQNY ARKYRIPIDL LAFDYEVMRE THVTAAPDDG VIVYGLFLDG
ARWDKNLMIL EESLPKVLYD VVPHIWMKPM KRDDIKPKET YLCPVYKTSE RRGVLSTTGH
STNFVIAMTL PTRKPEKHWI MRGVAMLCQL SQLWKSSARG RGRPGRGRHT VSQQLVAMVS
APATRADIDL SGNPPLLFSA QKLHQARKID ARFLLFKAMK WEASKLPKII PSFKLYLHTE
LLVKER
//
