ID A0A139WND7_TRICA Unreviewed; 2453 AA.
AC A0A139WND7;
DT 11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT 11-MAY-2016, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE SubName: Full=Fat-like cadherin-related tumor suppressor homolog {ECO:0000313|EMBL:KYB29315.1};
GN Name=AUGUSTUS-3.0.2_32189 {ECO:0000313|EMBL:KYB29315.1};
GN ORFNames=TcasGA2_TC032189 {ECO:0000313|EMBL:KYB29315.1};
OS Tribolium castaneum (Red flour beetle).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Tenebrionidae; Tenebrionidae incertae sedis; Tribolium.
OX NCBI_TaxID=7070 {ECO:0000313|EMBL:KYB29315.1, ECO:0000313|Proteomes:UP000007266};
RN [1] {ECO:0000313|EMBL:KYB29315.1, ECO:0000313|Proteomes:UP000007266}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Georgia GA2 {ECO:0000313|EMBL:KYB29315.1,
RC ECO:0000313|Proteomes:UP000007266};
RX PubMed=18362917; DOI=10.1038/nature06784;
RG Tribolium Genome Sequencing Consortium;
RA Richards S., Gibbs R.A., Weinstock G.M., Brown S.J., Denell R.,
RA Beeman R.W., Gibbs R., Beeman R.W., Brown S.J., Bucher G., Friedrich M.,
RA Grimmelikhuijzen C.J., Klingler M., Lorenzen M., Richards S., Roth S.,
RA Schroder R., Tautz D., Zdobnov E.M., Muzny D., Gibbs R.A., Weinstock G.M.,
RA Attaway T., Bell S., Buhay C.J., Chandrabose M.N., Chavez D.,
RA Clerk-Blankenburg K.P., Cree A., Dao M., Davis C., Chacko J., Dinh H.,
RA Dugan-Rocha S., Fowler G., Garner T.T., Garnes J., Gnirke A., Hawes A.,
RA Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N., Joshi V.,
RA Khan Z.M., Jackson L., Kovar C., Kowis A., Lee S., Lewis L.R., Margolis J.,
RA Morgan M., Nazareth L.V., Nguyen N., Okwuonu G., Parker D., Richards S.,
RA Ruiz S.J., Santibanez J., Savard J., Scherer S.E., Schneider B.,
RA Sodergren E., Tautz D., Vattahil S., Villasana D., White C.S., Wright R.,
RA Park Y., Beeman R.W., Lord J., Oppert B., Lorenzen M., Brown S., Wang L.,
RA Savard J., Tautz D., Richards S., Weinstock G., Gibbs R.A., Liu Y.,
RA Worley K., Weinstock G., Elsik C.G., Reese J.T., Elhaik E., Landan G.,
RA Graur D., Arensburger P., Atkinson P., Beeman R.W., Beidler J., Brown S.J.,
RA Demuth J.P., Drury D.W., Du Y.Z., Fujiwara H., Lorenzen M., Maselli V.,
RA Osanai M., Park Y., Robertson H.M., Tu Z., Wang J.J., Wang S., Richards S.,
RA Song H., Zhang L., Sodergren E., Werner D., Stanke M., Morgenstern B.,
RA Solovyev V., Kosarev P., Brown G., Chen H.C., Ermolaeva O., Hlavina W.,
RA Kapustin Y., Kiryutin B., Kitts P., Maglott D., Pruitt K., Sapojnikov V.,
RA Souvorov A., Mackey A.J., Waterhouse R.M., Wyder S., Zdobnov E.M.,
RA Zdobnov E.M., Wyder S., Kriventseva E.V., Kadowaki T., Bork P., Aranda M.,
RA Bao R., Beermann A., Berns N., Bolognesi R., Bonneton F., Bopp D.,
RA Brown S.J., Bucher G., Butts T., Chaumot A., Denell R.E., Ferrier D.E.,
RA Friedrich M., Gordon C.M., Jindra M., Klingler M., Lan Q., Lattorff H.M.,
RA Laudet V., von Levetsow C., Liu Z., Lutz R., Lynch J.A., da Fonseca R.N.,
RA Posnien N., Reuter R., Roth S., Savard J., Schinko J.B., Schmitt C.,
RA Schoppmeier M., Schroder R., Shippy T.D., Simonnet F., Marques-Souza H.,
RA Tautz D., Tomoyasu Y., Trauner J., Van der Zee M., Vervoort M.,
RA Wittkopp N., Wimmer E.A., Yang X., Jones A.K., Sattelle D.B., Ebert P.R.,
RA Nelson D., Scott J.G., Beeman R.W., Muthukrishnan S., Kramer K.J.,
RA Arakane Y., Beeman R.W., Zhu Q., Hogenkamp D., Dixit R., Oppert B.,
RA Jiang H., Zou Z., Marshall J., Elpidina E., Vinokurov K., Oppert C.,
RA Zou Z., Evans J., Lu Z., Zhao P., Sumathipala N., Altincicek B.,
RA Vilcinskas A., Williams M., Hultmark D., Hetru C., Jiang H.,
RA Grimmelikhuijzen C.J., Hauser F., Cazzamali G., Williamson M., Park Y.,
RA Li B., Tanaka Y., Predel R., Neupert S., Schachtner J., Verleyen P.,
RA Raible F., Bork P., Friedrich M., Walden K.K., Robertson H.M., Angeli S.,
RA Foret S., Bucher G., Schuetz S., Maleszka R., Wimmer E.A., Beeman R.W.,
RA Lorenzen M., Tomoyasu Y., Miller S.C., Grossmann D., Bucher G.;
RT "The genome of the model beetle and pest Tribolium castaneum.";
RL Nature 452:949-955(2008).
RN [2] {ECO:0000313|EMBL:KYB29315.1, ECO:0000313|Proteomes:UP000007266}
RP GENOME REANNOTATION.
RC STRAIN=Georgia GA2 {ECO:0000313|EMBL:KYB29315.1,
RC ECO:0000313|Proteomes:UP000007266};
RX PubMed=19820115; DOI=10.1093/nar/gkp807;
RA Kim H.S., Murphy T., Xia J., Caragea D., Park Y., Beeman R.W.,
RA Lorenzen M.D., Butcher S., Manak J.R., Brown S.J.;
RT "BeetleBase in 2010: revisions to provide comprehensive genomic information
RT for Tribolium castaneum.";
RL Nucleic Acids Res. 38:D437-D442(2010).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; KQ971312; KYB29315.1; -; Genomic_DNA.
DR STRING; 7070.A0A139WND7; -.
DR EnsemblMetazoa; TC032189_001; TC032189_001; TC032189.
DR eggNOG; KOG1219; Eukaryota.
DR InParanoid; A0A139WND7; -.
DR OMA; CIPDSSD; -.
DR Proteomes; UP000007266; Linkage group 2.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProt.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0001736; P:establishment of planar polarity; IEA:UniProt.
DR GO; GO:0007163; P:establishment or maintenance of cell polarity; IEA:UniProt.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 13.
DR CDD; cd00054; EGF_CA; 5.
DR CDD; cd00110; LamG; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.40.60; Cadherins; 14.
DR Gene3D; 2.10.25.10; Laminin; 5.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR001791; Laminin_G.
DR PANTHER; PTHR24026; FAT ATYPICAL CADHERIN-RELATED; 1.
DR PANTHER; PTHR24026:SF51; PROTOCADHERIN-LIKE WING POLARITY PROTEIN STAN; 1.
DR Pfam; PF00028; Cadherin; 12.
DR Pfam; PF00008; EGF; 2.
DR Pfam; PF12661; hEGF; 1.
DR Pfam; PF02210; Laminin_G_2; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 14.
DR SMART; SM00181; EGF; 6.
DR SMART; SM00179; EGF_CA; 4.
DR SMART; SM00282; LamG; 1.
DR SUPFAM; SSF49313; Cadherin-like; 14.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 5.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS00232; CADHERIN_1; 6.
DR PROSITE; PS50268; CADHERIN_2; 14.
DR PROSITE; PS00022; EGF_1; 4.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 5.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS50025; LAM_G_DOMAIN; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007266};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 2036..2056
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 5..106
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 107..213
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 214..315
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 316..418
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 419..526
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 527..626
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 627..733
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 734..834
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 835..938
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 939..1042
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1043..1147
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1148..1252
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1253..1357
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1372..1472
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1623..1661
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1678..1859
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 1867..1903
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1905..1942
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1943..1978
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1980..2016
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 2265..2286
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2365..2395
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2265..2281
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 1632..1649
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1651..1660
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1893..1902
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1932..1941
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2006..2015
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2453 AA; 273209 MW; 2876F89501163F5C CRC64;
MPVFKKQFYS EVVPENVELH SPLSISIEAE SPLSRKLIYS IVKGNELEEF ALDFNTGVIS
VVDELDFEQQ PQYELLIRAT DSVSGVYAEV PVSIVLQDVN DCPPEFTQEN YNVSISEAAQ
FGTPVLTVIA NDNDTGINKK ISYSIQNDSS NSSEYFYIDE NEGVVYLKQA LDHEEASSHH
FIVVAKDLGV PSLSSTAHVW LTVLDMNDNP PKFEQTSYSC GLLINANRDQ FVTIVKASDP
DEVDQNSLRY TIVAGNEQQT FSMNPETGII TLTNLANFGN ENTMILNVSV SDGVYTNFAR
LKVELLPANL HEPKFDKFIV DVQVPENQPS GFPVTVVKAT DEDFGEFGTI TYSIHSELLS
EIFKIDKTSG KLTTKVRLDR EKQKLYEVLI MATDGGGKSG FITVRIKVAD ENDNAPYFLL
KEYQTSIHYN YSLNVLFLRV KAVDPDEGPA AQIRYQIYEK KSSEVVEIFQ INPETGDLSL
KKDTTSWIGE VFQFFVRATD KGPQEKHSDV PVNILIMGPK DYPPVFERKD EKYFLSENSP
AGTIITKLKM ASNVSATYQI ISELDEKPQF EIDNQGQVIL AKPLDFETQD SHLIGILALS
DSSPPMTALA EVALKVLDEN DHAPQFESSP YIIYLAENTE EGTSILKVVA HDEDQGANSE
VRYSFSHDLG DMMNIFAIDS HTGWISTLVK LDKEAKMEYK FYVTATDNGT PKHSARTTVI
VRLKDYNDSP TLFKKRFYES SVNEDALPGT VLLTLDTVDA DSDLTTPVEF YIISGDPSSQ
FQIRQTGEIY VAKGLDREKV PHYDLQVLVT DGMFTDVTNV SVNILDANDN PPYCLQYRYR
QVLSEGILPG SFVLSVLATD NDGPEHSKLR YILSGDGMDN FLLDKDSGHL KTVTYLDREK
QSKYTLTAHV HDKERLSWKC SSQIELIISD LNDNPPVFSL PFYSVSLPED VEVGTLVTKI
HATDADIGIN RKIKYAFIDS FNNHFKMASD SGIVTLAKPL DREIRAVYNL TVQAVDQGTP
QLSSVSTLTV NVQDINDNPP EFANKYYFAV VPEIDAVGTE VVKVLATSKD TGVNADVTYS
IIGGNEHKKF AINNKTGVIS IADMLDYERA KDYFLTIQAV DGGIPPLSNV ATVNITVTDC
NDNAPVFSQL SYSARIREDA QIGDKILQVI ATDLDSDRNG KVTYSIIRGD DREQFEIDPD
SGYVSVAEEL DRETTSNYVL EVLARDNGVP VLSRQTLLNI EISDANDNPP IFAQTNYTTV
IQEDKPIGYP IIQFKITDAD TAPNTEPYTF DFRSGNDGNS FRLEEDGVLR TATKFNHKIK
DNYLLQIRVF DNGIPPLYSD AWVVVKVIEE SQYPPIITPL EININSYLDE YPGGVIGKVY
ANDQDQYDTL TYSLSPTVGI AYPTHELFQI NRTDGTLTAL PRLDVGDYRL NVTVTDGKFH
THSIVKINIE VITEEMLENS VAIRFRQVSP EVFVLSHRKG FVRAVRNAMN CRLKDVIIIS
VQPSDDDASL RSKRFIVNKD LDVLFTVRKP DEGFFTSESI KKALNDNFEE LEESTKLVVE
EIVRFKCSNT YCTFGVCQDH YMLDPGRVDP VATDVTSFVS PYHRQKLECV CKEGYGGEKC
DTIVNECARE PCPPYKNCVP DASTAGYSCQ CPEGFAGAMC DVDISKCHDQ NCYIARNPIS
FSGKSYSQYR IINKKSIEDQ LSLSLRIRTV QPTGNLMYAA GKVDYNILEI VNGAVQYRFE
LGSGEGIVRE STVYISDGRW HEVKLERDRN SAKITVDGLH TAQGSAPGIS DILNLQSDEM
YLGAEVHQHP SILGFEDIQR GFSGCMDDIR ISRMSVPLHK SGDNSVAVLK RFANVEFSCD
VNNVLVPPGP CGSQPCMNGG TCHETTAGYE CSCHTRFTGT LCELDMDPCA SAPCLNGGKC
ISTVPGDYSC ECLFRLSGKR CEYGKYCSPN PCKHGGVCEE GDDRALCKCR AFVGDYCEFD
LNECESSPCQ NGGSCFNDVG SFHCVCPQNT TGPYCGSQLY STSITSSIYN ITWEELVAIA
VGIVLILLLV ILFVICRKCY TKRTRRRRNI NNENIKDHIV LNSTRPHEMS EFKRGSKLSN
LEVNQREIPV CPPRPVSYTA TSQNDALYNC NNTMMLNNLD TLRSYGSAGD ELENVPPDYV
RNLNRNTGQN CISNHCEPEK TTWAEQMHLA SSLNDKPKVK NDYKISSPVN CDVPNRLYGG
RSNTMNYVKS NGSVCPEEDQ RSVGSYHWDC SDWARHSQTL PNITEVPGSE IPDSSSFHSN
ESNESRCHHL PPVLGPLDPH RDIETLNEDA ESEFMADSEY DAHGASPSLN ALDSGNEEFR
FTTADSYIRH PNSYLPSHGY NIPSESEGEC LQSPGAESDD VEPYGFPSNR NRRKNCDDDI
GSVITTLEER NSLLGGYGSN SDLSTNLCEI EDSECEAEHK PLNYLGGVQQ TSV
//