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Database: UniProt
Entry: A0A139WND7_TRICA
LinkDB: A0A139WND7_TRICA
Original site: A0A139WND7_TRICA 
ID   A0A139WND7_TRICA        Unreviewed;      2453 AA.
AC   A0A139WND7;
DT   11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT   11-MAY-2016, sequence version 1.
DT   24-JAN-2024, entry version 39.
DE   SubName: Full=Fat-like cadherin-related tumor suppressor homolog {ECO:0000313|EMBL:KYB29315.1};
GN   Name=AUGUSTUS-3.0.2_32189 {ECO:0000313|EMBL:KYB29315.1};
GN   ORFNames=TcasGA2_TC032189 {ECO:0000313|EMBL:KYB29315.1};
OS   Tribolium castaneum (Red flour beetle).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC   Tenebrionidae; Tenebrionidae incertae sedis; Tribolium.
OX   NCBI_TaxID=7070 {ECO:0000313|EMBL:KYB29315.1, ECO:0000313|Proteomes:UP000007266};
RN   [1] {ECO:0000313|EMBL:KYB29315.1, ECO:0000313|Proteomes:UP000007266}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Georgia GA2 {ECO:0000313|EMBL:KYB29315.1,
RC   ECO:0000313|Proteomes:UP000007266};
RX   PubMed=18362917; DOI=10.1038/nature06784;
RG   Tribolium Genome Sequencing Consortium;
RA   Richards S., Gibbs R.A., Weinstock G.M., Brown S.J., Denell R.,
RA   Beeman R.W., Gibbs R., Beeman R.W., Brown S.J., Bucher G., Friedrich M.,
RA   Grimmelikhuijzen C.J., Klingler M., Lorenzen M., Richards S., Roth S.,
RA   Schroder R., Tautz D., Zdobnov E.M., Muzny D., Gibbs R.A., Weinstock G.M.,
RA   Attaway T., Bell S., Buhay C.J., Chandrabose M.N., Chavez D.,
RA   Clerk-Blankenburg K.P., Cree A., Dao M., Davis C., Chacko J., Dinh H.,
RA   Dugan-Rocha S., Fowler G., Garner T.T., Garnes J., Gnirke A., Hawes A.,
RA   Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N., Joshi V.,
RA   Khan Z.M., Jackson L., Kovar C., Kowis A., Lee S., Lewis L.R., Margolis J.,
RA   Morgan M., Nazareth L.V., Nguyen N., Okwuonu G., Parker D., Richards S.,
RA   Ruiz S.J., Santibanez J., Savard J., Scherer S.E., Schneider B.,
RA   Sodergren E., Tautz D., Vattahil S., Villasana D., White C.S., Wright R.,
RA   Park Y., Beeman R.W., Lord J., Oppert B., Lorenzen M., Brown S., Wang L.,
RA   Savard J., Tautz D., Richards S., Weinstock G., Gibbs R.A., Liu Y.,
RA   Worley K., Weinstock G., Elsik C.G., Reese J.T., Elhaik E., Landan G.,
RA   Graur D., Arensburger P., Atkinson P., Beeman R.W., Beidler J., Brown S.J.,
RA   Demuth J.P., Drury D.W., Du Y.Z., Fujiwara H., Lorenzen M., Maselli V.,
RA   Osanai M., Park Y., Robertson H.M., Tu Z., Wang J.J., Wang S., Richards S.,
RA   Song H., Zhang L., Sodergren E., Werner D., Stanke M., Morgenstern B.,
RA   Solovyev V., Kosarev P., Brown G., Chen H.C., Ermolaeva O., Hlavina W.,
RA   Kapustin Y., Kiryutin B., Kitts P., Maglott D., Pruitt K., Sapojnikov V.,
RA   Souvorov A., Mackey A.J., Waterhouse R.M., Wyder S., Zdobnov E.M.,
RA   Zdobnov E.M., Wyder S., Kriventseva E.V., Kadowaki T., Bork P., Aranda M.,
RA   Bao R., Beermann A., Berns N., Bolognesi R., Bonneton F., Bopp D.,
RA   Brown S.J., Bucher G., Butts T., Chaumot A., Denell R.E., Ferrier D.E.,
RA   Friedrich M., Gordon C.M., Jindra M., Klingler M., Lan Q., Lattorff H.M.,
RA   Laudet V., von Levetsow C., Liu Z., Lutz R., Lynch J.A., da Fonseca R.N.,
RA   Posnien N., Reuter R., Roth S., Savard J., Schinko J.B., Schmitt C.,
RA   Schoppmeier M., Schroder R., Shippy T.D., Simonnet F., Marques-Souza H.,
RA   Tautz D., Tomoyasu Y., Trauner J., Van der Zee M., Vervoort M.,
RA   Wittkopp N., Wimmer E.A., Yang X., Jones A.K., Sattelle D.B., Ebert P.R.,
RA   Nelson D., Scott J.G., Beeman R.W., Muthukrishnan S., Kramer K.J.,
RA   Arakane Y., Beeman R.W., Zhu Q., Hogenkamp D., Dixit R., Oppert B.,
RA   Jiang H., Zou Z., Marshall J., Elpidina E., Vinokurov K., Oppert C.,
RA   Zou Z., Evans J., Lu Z., Zhao P., Sumathipala N., Altincicek B.,
RA   Vilcinskas A., Williams M., Hultmark D., Hetru C., Jiang H.,
RA   Grimmelikhuijzen C.J., Hauser F., Cazzamali G., Williamson M., Park Y.,
RA   Li B., Tanaka Y., Predel R., Neupert S., Schachtner J., Verleyen P.,
RA   Raible F., Bork P., Friedrich M., Walden K.K., Robertson H.M., Angeli S.,
RA   Foret S., Bucher G., Schuetz S., Maleszka R., Wimmer E.A., Beeman R.W.,
RA   Lorenzen M., Tomoyasu Y., Miller S.C., Grossmann D., Bucher G.;
RT   "The genome of the model beetle and pest Tribolium castaneum.";
RL   Nature 452:949-955(2008).
RN   [2] {ECO:0000313|EMBL:KYB29315.1, ECO:0000313|Proteomes:UP000007266}
RP   GENOME REANNOTATION.
RC   STRAIN=Georgia GA2 {ECO:0000313|EMBL:KYB29315.1,
RC   ECO:0000313|Proteomes:UP000007266};
RX   PubMed=19820115; DOI=10.1093/nar/gkp807;
RA   Kim H.S., Murphy T., Xia J., Caragea D., Park Y., Beeman R.W.,
RA   Lorenzen M.D., Butcher S., Manak J.R., Brown S.J.;
RT   "BeetleBase in 2010: revisions to provide comprehensive genomic information
RT   for Tribolium castaneum.";
RL   Nucleic Acids Res. 38:D437-D442(2010).
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR   EMBL; KQ971312; KYB29315.1; -; Genomic_DNA.
DR   STRING; 7070.A0A139WND7; -.
DR   EnsemblMetazoa; TC032189_001; TC032189_001; TC032189.
DR   eggNOG; KOG1219; Eukaryota.
DR   InParanoid; A0A139WND7; -.
DR   OMA; CIPDSSD; -.
DR   Proteomes; UP000007266; Linkage group 2.
DR   GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR   GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProt.
DR   GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR   GO; GO:0001736; P:establishment of planar polarity; IEA:UniProt.
DR   GO; GO:0007163; P:establishment or maintenance of cell polarity; IEA:UniProt.
DR   GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR   CDD; cd11304; Cadherin_repeat; 13.
DR   CDD; cd00054; EGF_CA; 5.
DR   CDD; cd00110; LamG; 1.
DR   Gene3D; 2.60.120.200; -; 1.
DR   Gene3D; 2.60.40.60; Cadherins; 14.
DR   Gene3D; 2.10.25.10; Laminin; 5.
DR   InterPro; IPR002126; Cadherin-like_dom.
DR   InterPro; IPR015919; Cadherin-like_sf.
DR   InterPro; IPR020894; Cadherin_CS.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR   InterPro; IPR018097; EGF_Ca-bd_CS.
DR   InterPro; IPR001791; Laminin_G.
DR   PANTHER; PTHR24026; FAT ATYPICAL CADHERIN-RELATED; 1.
DR   PANTHER; PTHR24026:SF51; PROTOCADHERIN-LIKE WING POLARITY PROTEIN STAN; 1.
DR   Pfam; PF00028; Cadherin; 12.
DR   Pfam; PF00008; EGF; 2.
DR   Pfam; PF12661; hEGF; 1.
DR   Pfam; PF02210; Laminin_G_2; 1.
DR   PRINTS; PR00205; CADHERIN.
DR   SMART; SM00112; CA; 14.
DR   SMART; SM00181; EGF; 6.
DR   SMART; SM00179; EGF_CA; 4.
DR   SMART; SM00282; LamG; 1.
DR   SUPFAM; SSF49313; Cadherin-like; 14.
DR   SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR   SUPFAM; SSF57196; EGF/Laminin; 5.
DR   PROSITE; PS00010; ASX_HYDROXYL; 1.
DR   PROSITE; PS00232; CADHERIN_1; 6.
DR   PROSITE; PS50268; CADHERIN_2; 14.
DR   PROSITE; PS00022; EGF_1; 4.
DR   PROSITE; PS01186; EGF_2; 1.
DR   PROSITE; PS50026; EGF_3; 5.
DR   PROSITE; PS01187; EGF_CA; 1.
DR   PROSITE; PS50025; LAM_G_DOMAIN; 1.
PE   4: Predicted;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW   ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW   ProRule:PRU00076};
KW   EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW   ProRule:PRU00076}; Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007266};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        2036..2056
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          5..106
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          107..213
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          214..315
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          316..418
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          419..526
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          527..626
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          627..733
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          734..834
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          835..938
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          939..1042
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          1043..1147
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          1148..1252
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          1253..1357
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          1372..1472
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          1623..1661
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          1678..1859
FT                   /note="Laminin G"
FT                   /evidence="ECO:0000259|PROSITE:PS50025"
FT   DOMAIN          1867..1903
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          1905..1942
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          1943..1978
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          1980..2016
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   REGION          2265..2286
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2365..2395
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2265..2281
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        1632..1649
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        1651..1660
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        1893..1902
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        1932..1941
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        2006..2015
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ   SEQUENCE   2453 AA;  273209 MW;  2876F89501163F5C CRC64;
     MPVFKKQFYS EVVPENVELH SPLSISIEAE SPLSRKLIYS IVKGNELEEF ALDFNTGVIS
     VVDELDFEQQ PQYELLIRAT DSVSGVYAEV PVSIVLQDVN DCPPEFTQEN YNVSISEAAQ
     FGTPVLTVIA NDNDTGINKK ISYSIQNDSS NSSEYFYIDE NEGVVYLKQA LDHEEASSHH
     FIVVAKDLGV PSLSSTAHVW LTVLDMNDNP PKFEQTSYSC GLLINANRDQ FVTIVKASDP
     DEVDQNSLRY TIVAGNEQQT FSMNPETGII TLTNLANFGN ENTMILNVSV SDGVYTNFAR
     LKVELLPANL HEPKFDKFIV DVQVPENQPS GFPVTVVKAT DEDFGEFGTI TYSIHSELLS
     EIFKIDKTSG KLTTKVRLDR EKQKLYEVLI MATDGGGKSG FITVRIKVAD ENDNAPYFLL
     KEYQTSIHYN YSLNVLFLRV KAVDPDEGPA AQIRYQIYEK KSSEVVEIFQ INPETGDLSL
     KKDTTSWIGE VFQFFVRATD KGPQEKHSDV PVNILIMGPK DYPPVFERKD EKYFLSENSP
     AGTIITKLKM ASNVSATYQI ISELDEKPQF EIDNQGQVIL AKPLDFETQD SHLIGILALS
     DSSPPMTALA EVALKVLDEN DHAPQFESSP YIIYLAENTE EGTSILKVVA HDEDQGANSE
     VRYSFSHDLG DMMNIFAIDS HTGWISTLVK LDKEAKMEYK FYVTATDNGT PKHSARTTVI
     VRLKDYNDSP TLFKKRFYES SVNEDALPGT VLLTLDTVDA DSDLTTPVEF YIISGDPSSQ
     FQIRQTGEIY VAKGLDREKV PHYDLQVLVT DGMFTDVTNV SVNILDANDN PPYCLQYRYR
     QVLSEGILPG SFVLSVLATD NDGPEHSKLR YILSGDGMDN FLLDKDSGHL KTVTYLDREK
     QSKYTLTAHV HDKERLSWKC SSQIELIISD LNDNPPVFSL PFYSVSLPED VEVGTLVTKI
     HATDADIGIN RKIKYAFIDS FNNHFKMASD SGIVTLAKPL DREIRAVYNL TVQAVDQGTP
     QLSSVSTLTV NVQDINDNPP EFANKYYFAV VPEIDAVGTE VVKVLATSKD TGVNADVTYS
     IIGGNEHKKF AINNKTGVIS IADMLDYERA KDYFLTIQAV DGGIPPLSNV ATVNITVTDC
     NDNAPVFSQL SYSARIREDA QIGDKILQVI ATDLDSDRNG KVTYSIIRGD DREQFEIDPD
     SGYVSVAEEL DRETTSNYVL EVLARDNGVP VLSRQTLLNI EISDANDNPP IFAQTNYTTV
     IQEDKPIGYP IIQFKITDAD TAPNTEPYTF DFRSGNDGNS FRLEEDGVLR TATKFNHKIK
     DNYLLQIRVF DNGIPPLYSD AWVVVKVIEE SQYPPIITPL EININSYLDE YPGGVIGKVY
     ANDQDQYDTL TYSLSPTVGI AYPTHELFQI NRTDGTLTAL PRLDVGDYRL NVTVTDGKFH
     THSIVKINIE VITEEMLENS VAIRFRQVSP EVFVLSHRKG FVRAVRNAMN CRLKDVIIIS
     VQPSDDDASL RSKRFIVNKD LDVLFTVRKP DEGFFTSESI KKALNDNFEE LEESTKLVVE
     EIVRFKCSNT YCTFGVCQDH YMLDPGRVDP VATDVTSFVS PYHRQKLECV CKEGYGGEKC
     DTIVNECARE PCPPYKNCVP DASTAGYSCQ CPEGFAGAMC DVDISKCHDQ NCYIARNPIS
     FSGKSYSQYR IINKKSIEDQ LSLSLRIRTV QPTGNLMYAA GKVDYNILEI VNGAVQYRFE
     LGSGEGIVRE STVYISDGRW HEVKLERDRN SAKITVDGLH TAQGSAPGIS DILNLQSDEM
     YLGAEVHQHP SILGFEDIQR GFSGCMDDIR ISRMSVPLHK SGDNSVAVLK RFANVEFSCD
     VNNVLVPPGP CGSQPCMNGG TCHETTAGYE CSCHTRFTGT LCELDMDPCA SAPCLNGGKC
     ISTVPGDYSC ECLFRLSGKR CEYGKYCSPN PCKHGGVCEE GDDRALCKCR AFVGDYCEFD
     LNECESSPCQ NGGSCFNDVG SFHCVCPQNT TGPYCGSQLY STSITSSIYN ITWEELVAIA
     VGIVLILLLV ILFVICRKCY TKRTRRRRNI NNENIKDHIV LNSTRPHEMS EFKRGSKLSN
     LEVNQREIPV CPPRPVSYTA TSQNDALYNC NNTMMLNNLD TLRSYGSAGD ELENVPPDYV
     RNLNRNTGQN CISNHCEPEK TTWAEQMHLA SSLNDKPKVK NDYKISSPVN CDVPNRLYGG
     RSNTMNYVKS NGSVCPEEDQ RSVGSYHWDC SDWARHSQTL PNITEVPGSE IPDSSSFHSN
     ESNESRCHHL PPVLGPLDPH RDIETLNEDA ESEFMADSEY DAHGASPSLN ALDSGNEEFR
     FTTADSYIRH PNSYLPSHGY NIPSESEGEC LQSPGAESDD VEPYGFPSNR NRRKNCDDDI
     GSVITTLEER NSLLGGYGSN SDLSTNLCEI EDSECEAEHK PLNYLGGVQQ TSV
//
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