ID   A0A139WSM5_9CYAN        Unreviewed;       860 AA.
AC   A0A139WSM5;
DT   11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT   11-MAY-2016, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=Diguanylate cyclase {ECO:0000313|EMBL:KYC35430.1};
GN   ORFNames=WA1_06280 {ECO:0000313|EMBL:KYC35430.1};
OS   Scytonema hofmannii PCC 7110.
OC   Bacteria; Cyanobacteriota; Cyanophyceae; Nostocales; Scytonemataceae;
OC   Scytonema.
OX   NCBI_TaxID=128403 {ECO:0000313|EMBL:KYC35430.1, ECO:0000313|Proteomes:UP000076925};
RN   [1] {ECO:0000313|EMBL:KYC35430.1, ECO:0000313|Proteomes:UP000076925}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PCC 7110 {ECO:0000313|EMBL:KYC35430.1,
RC   ECO:0000313|Proteomes:UP000076925};
RX   PubMed=23221676; DOI=10.1093/gbe/evs117;
RA   Dagan T., Roettger M., Stucken K., Landan G., Koch R., Major P.,
RA   Gould S.B., Goremykin V.V., Rippka R., Tandeau de Marsac N., Gugger M.,
RA   Lockhart P.J., Allen J.F., Brune I., Maus I., Puhler A., Martin W.F.;
RT   "Genomes of Stigonematalean cyanobacteria (subsection V) and the evolution
RT   of oxygenic photosynthesis from prokaryotes to plastids.";
RL   Genome Biol. Evol. 5:31-44(2013).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KYC35430.1}.
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DR   EMBL; ANNX02000051; KYC35430.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A139WSM5; -.
DR   STRING; 128403.WA1_06280; -.
DR   Proteomes; UP000076925; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   CDD; cd01948; EAL; 1.
DR   CDD; cd01949; GGDEF; 1.
DR   Gene3D; 3.30.70.270; -; 1.
DR   Gene3D; 3.20.20.450; EAL domain; 1.
DR   InterPro; IPR007890; CHASE2.
DR   InterPro; IPR001633; EAL_dom.
DR   InterPro; IPR035919; EAL_sf.
DR   InterPro; IPR000160; GGDEF_dom.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   NCBIfam; TIGR00254; GGDEF; 1.
DR   PANTHER; PTHR33121; CYCLIC DI-GMP PHOSPHODIESTERASE PDEF; 1.
DR   PANTHER; PTHR33121:SF85; CYCLIC DI-GMP PHOSPHODIESTERASE PDEK-RELATED; 1.
DR   Pfam; PF05226; CHASE2; 1.
DR   Pfam; PF00563; EAL; 1.
DR   Pfam; PF00990; GGDEF; 1.
DR   SMART; SM01080; CHASE2; 1.
DR   SMART; SM00052; EAL; 1.
DR   SMART; SM00267; GGDEF; 1.
DR   SUPFAM; SSF141868; EAL domain-like; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   PROSITE; PS50883; EAL; 1.
DR   PROSITE; PS50887; GGDEF; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000076925};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        361..383
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        389..410
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          444..578
FT                   /note="GGDEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50887"
FT   DOMAIN          587..843
FT                   /note="EAL"
FT                   /evidence="ECO:0000259|PROSITE:PS50883"
SQ   SEQUENCE   860 AA;  96026 MW;  57867EACE05656A4 CRC64;
     MIPQFTKKLS SLLSVVNSYC QHKAIATLSV KQSVLAASIL MAGLVLATRY TGALQFLELL
     AFDQMVRLVS NSEPDERLLV VTITEADIEQ LKQWPISDQT LAKALKNLQQ YKPKVIGIDL
     YRNLPVPPGE NALLKELRLP NVISIYELGG MDTEGVASIP GVSPEQTGFN DLLLDPDGVI
     RRNLMYAYEG EKKYYSFSLR LSLKYLAEQN ISFKTTPDGL QLGSTTFPAL STHSGGYHNL
     DNAGYQAIAS YRSADVARQV TFSQVLRGEI NPNLVKDRVV LIGTTAPSIK DIFFTPYNAG
     QSAKPRTPGV FLHAQFVSQL LKTTLDREPL IWFWSEWEEA LWIFSWALIG GVLACRLRHP
     LFLGVVGVVS WAGLYGVCFY IFLQGGWIPF VPASLTLITT GISTFCYVLL RSSLHDPLTD
     LPNRDCFLKS LEVAIANSQF RQNMRFAVLF LNLDRFKIIN ESLGYQVGDQ LLKNTAQRLK
     ASVRSRGTVA RVGGDEFAIL LGNINHTSEA TQLADELQQQ ISQPFQKDGQ EIFTSISIGI
     AFNQSELNYH PVELLRDAHI AMYRAKDLGK ARHQVFATGM HTQVIKRFQL EADLRRGIEL
     EELYLVYQPI VSLITETIAG FEALIRWNHP KYGFVSPLEF ISVAEETGLI IPLGKWIFQA
     ACRQLSIWQA QFPANPSLMM SINLSGQQLT QPDLVEYVEQ SLKETGLDGR SVKLEITESV
     AMKDVEAAIS IMLRLRGLNL RLSIDDFGTG YSSLSYLHRF PVNTLKIDRS FVSRMEDTDE
     DAAIVQTIIM LSHSLGMDVV AEGVETVEQK AKLQALNCEY GQGYFFAKPL DSKTATALLQ
     SQFSTLDSCS VEEQYKMPQA
//