ID A0A139XDE9_9CYAN Unreviewed; 2648 AA.
AC A0A139XDE9;
DT 11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT 11-MAY-2016, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=Non-ribosomal peptide synthetase {ECO:0000313|EMBL:KYC42719.1};
GN ORFNames=WA1_15380 {ECO:0000313|EMBL:KYC42719.1};
OS Scytonema hofmannii PCC 7110.
OC Bacteria; Cyanobacteriota; Cyanophyceae; Nostocales; Scytonemataceae;
OC Scytonema.
OX NCBI_TaxID=128403 {ECO:0000313|EMBL:KYC42719.1, ECO:0000313|Proteomes:UP000076925};
RN [1] {ECO:0000313|EMBL:KYC42719.1, ECO:0000313|Proteomes:UP000076925}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PCC 7110 {ECO:0000313|EMBL:KYC42719.1,
RC ECO:0000313|Proteomes:UP000076925};
RX PubMed=23221676; DOI=10.1093/gbe/evs117;
RA Dagan T., Roettger M., Stucken K., Landan G., Koch R., Major P.,
RA Gould S.B., Goremykin V.V., Rippka R., Tandeau de Marsac N., Gugger M.,
RA Lockhart P.J., Allen J.F., Brune I., Maus I., Puhler A., Martin W.F.;
RT "Genomes of Stigonematalean cyanobacteria (subsection V) and the evolution
RT of oxygenic photosynthesis from prokaryotes to plastids.";
RL Genome Biol. Evol. 5:31-44(2013).
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYC42719.1}.
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DR EMBL; ANNX02000017; KYC42719.1; -; Genomic_DNA.
DR RefSeq; WP_017742640.1; NZ_KQ976354.1.
DR STRING; 128403.WA1_15380; -.
DR OrthoDB; 473401at2; -.
DR Proteomes; UP000076925; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR GO; GO:0009403; P:toxin biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 1.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd19531; LCL_NRPS-like; 2.
DR Gene3D; 3.30.300.30; -; 3.
DR Gene3D; 3.40.50.980; -; 4.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 2.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 2.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR013217; Methyltransf_12.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 2.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 2.
DR Pfam; PF13193; AMP-binding_C; 1.
DR Pfam; PF00668; Condensation; 2.
DR Pfam; PF08242; Methyltransf_12; 1.
DR Pfam; PF00550; PP-binding; 2.
DR SMART; SM00823; PKS_PP; 2.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 4.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00455; AMP_BINDING; 2.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000076925};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1012..1087
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2545..2627
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 2648 AA; 300787 MW; 170FDFDA5180641B CRC64;
MSDLLKRLET LSPEKRELVL QKLKKQQQSS QNDRRLTPLL TPVSREQPLL LSFAQQRLWF
LDQLEGKNCV YNVPFFWQLR GFLNISALEQ AIREIVQRHE VLRTTFSVVD GSPIQVIHAH
LQLMVQVLDW RQLTGQDQLS KAQQLATEEL QQPFDLSKPP LLRVKLLQLA ERSHLLLLVI
HHIVCDGWSM EIFRRELFAL YTAFCSGEAS PLPELSLQYA DFAYWQRQWL QGEILQTQLN
YWQKQLVAVP PLLELPTRPR PSVQSFRGRS IFLQLDRDLS QKLMHLSQES GTTLFMTLLG
AFTLLLSRYS GQEDIVVGSA IANRNCREIE TLIGFFVNTL ALRTNLQGNP TFLELLNRVK
QVTLNAYDHQ DLPFEKLVDE LGQERSLSHH PLFQVGFSLQ NEQEQRLETH GLDVTLFQWE
NTTTFLDLLL TFRQTPQGLR GEWEYATDLF EAKTIRRMAE HFKILLQGIV DKPNQPIHSL
PLLTDDERQQ LQIWNQTQTD YPLERTLVDL FEAQVENNPH NLALVFESQS LTYQQLNQKA
NQLAHYLIQK HQIQPDTLIG ICVERSVEMI IGVLGILKAG GAYVPIDPKY PQRRIQFMLE
DSGTSVLLTQ SFLLNKLLGA NTEYPHKVIC LDETTFAEES TKNPSPRSTP NNLAYLIYTS
GSTGRPKGVT IEHRAVVNLS FACANTFQVQ TQSRLLQFGS LSFDSSVAEI ATAFVTGACL
YLANEETLLP SQILVDFLTD RKITHSFFPS SVLSVLPQAT LSDLRYLGVG GEPCSKELVT
RWAQGRRFFN CYGPTEATVN AAIATLTTGN VLCQANITKP PIGQPLSNTR IYILDAYNQP
LPIGIPGELC IAGVGLARGY LNRPETTKRK FLEVELFGKT ERIYKTGDRA RWLTDGNLEY
LGRLDNQVKL RGFRIELGEI ESLLLHCSSV REAVVILHEA DNNSRLVAYI TVIEKSVNLG
DRLKDYLKTH LPNYMVPSQI MVLDKLPLTP NGKLDRRSLP APDIATSTEE EMPVTPTEKL
LAALWQTLLK TKSVSRQDNF FELGGHSLLA TQLVARIRDI FGVELPVRKV FEQSILSELA
TEIDSRGAMP CARTTIAPQP ENDSKVLSFA QSRLWFLAQL EGKGTSATYN MPMALQLEGN
LNIEALRASF AYVLKRHASL RTYFPVVEGK PQVVVQNPED IEVLEFVDLQ ELDLQTQAKT
VQWLADNHAQ EPFDLNTGPL FKAKLLQLQQ QKYVLLVNMH HIISDGWSMG VFKREWQQAY
LAFLRGEAPN WEELPIQYSD YAAWQRNWLQ GNILESQENY WKQQLNGAPR LLDLPTDYPR
PAQQSYQGGR EEYRLSSELT LSLKRVSQKY EVSLFMTLLT AFSILLSRYS RQEDICVGTA
IANRTHSHTE GLIGFFVNTL VLRSQVKPEQ EFNKLLQQIR QTCLDAYAHQ DIPFEYLVEQ
LQPERSLSHN PLFQVMMVLQ NTESAGTNVN LPGLDIQYWE QSYPFAKFDL TVDLCERGDQ
LHCMWEYATD LFEAETIRRM AGHFEVLLEA ICLQHAGATQ NTQQQIIGQL PLMTIAEIQQ
LRRWNQTDTN YPQDQTLVTL FEQQVAKTPD NIAVVFEDCS LSYQELNQKA NQLANYLLQF
QKEQKLHNNL AIAICMERSL SMVIGLFGIL KAGGAYVPID PNYPQERIRF MLEDCGAQIL
LTHSQLKDKL GIEHWGLDIG DQQTLSQSPL PLIPRGGPEF PSPQFLILCL DKDNFANQST
ENPSCHQPND LAYIIYTSGS TGRPKGVQLL HRGLTNYLHW AKNFYAVAQG QGTAVQSSLS
FDATITSLYL PLICGRTTAL VREKQEIEVL ADILEQNNHL SLIKITPSHL EILNQQLAPH
MMQNRVNALV LGGEVLRINQ ITPWLTHAPE TRLINEYGPT ETVVGCCVYE ATGKRDLVGN
LLIGQPIANV RIYILDNQNQ ALPPGIPGEL CIAGTPLARG YLNRPELTAE KFIELDLLGE
RERVYKTGDL ARWLPDGNLE YLGRIDNQVK LRGFRIELGE IEALLAKHPK IGQAVVIVKG
EDAIDRRLLA YIVPTPTDND LENQSLQAEQ VGLWQQVFND SYSQQQASTD DPTLNLAGWN
DSYTGKSIPQ AAMQEWRDTI VGQILELEPK RVWEIGCGTG MLLFKIAPHC QHYLGTDFSS
EALHHIEQHL KQLSFQDSHS RENPSSLTPY LQDRITLKHS AANQFDGIET NAHDLVIMNS
VIQYFPSLDY FLEVLEGAVN AVTTQGTIFI GDVRNLHLQE AFQTSVEFER APDDLSIKDL
RLQIQKSIRT EGELLIDPDF FIALKQRIPR ISQVQIQLQR GYALTEMSRF RYNATLYLDR
ADTPLEEPEW LDWQTEQLNL ETIEKILTTQ QPDLLGIKDI PNARLTSEME MLEQIGQLDG
TVLDLKAAVA QAKSGIEPEV FRTLVRDLPY TPFIQYSSPG FSCYDVVFQR NIPGQVTLPR
FAIEKNLRLK PWQHYANQPL KYRTNPVDPA LLVEWRDFLE KNLPDYMIPS HFTVLKQLPL
TPNGKVDRKA LPIADEAVLS TDIELPVTST EKVLAQLWAK LLKYEAMSAL GVGVARQDNF
FNLGGHSLLA TQLCARIRDS FKIELPLRKV FEYPTLSELA NYLDTCIWVN SATTDMQPLN
SDEEEIEL
//
