ID A0A139YC60_GIBM7 Unreviewed; 2078 AA.
AC A0A139YC60;
DT 11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT 11-MAY-2016, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Neurofibromin 1 {ECO:0000313|EMBL:KYG13832.1};
GN ORFNames=FVEG_17759 {ECO:0000313|EMBL:KYG13832.1};
OS Gibberella moniliformis (strain M3125 / FGSC 7600) (Maize ear and stalk rot
OS fungus) (Fusarium verticillioides).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC Fusarium fujikuroi species complex.
OX NCBI_TaxID=334819 {ECO:0000313|EMBL:KYG13832.1};
RN [1] {ECO:0000313|Proteomes:UP000009096}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=M3125 / FGSC 7600 {ECO:0000313|Proteomes:UP000009096};
RX PubMed=17823352; DOI=10.1126/science.1143708;
RA Cuomo C.A., Gueldener U., Xu J.-R., Trail F., Turgeon B.G., Di Pietro A.,
RA Walton J.D., Ma L.-J., Baker S.E., Rep M., Adam G., Antoniw J., Baldwin T.,
RA Calvo S.E., Chang Y.-L., DeCaprio D., Gale L.R., Gnerre S., Goswami R.S.,
RA Hammond-Kosack K., Harris L.J., Hilburn K., Kennell J.C., Kroken S.,
RA Magnuson J.K., Mannhaupt G., Mauceli E.W., Mewes H.-W., Mitterbauer R.,
RA Muehlbauer G., Muensterkoetter M., Nelson D., O'Donnell K., Ouellet T.,
RA Qi W., Quesneville H., Roncero M.I.G., Seong K.-Y., Tetko I.V., Urban M.,
RA Waalwijk C., Ward T.J., Yao J., Birren B.W., Kistler H.C.;
RT "The Fusarium graminearum genome reveals a link between localized
RT polymorphism and pathogen specialization.";
RL Science 317:1400-1402(2007).
RN [2] {ECO:0000313|EMBL:KYG13832.1, ECO:0000313|Proteomes:UP000009096}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=M3125 / FGSC 7600 {ECO:0000313|Proteomes:UP000009096};
RX PubMed=20237561; DOI=10.1038/nature08850;
RA Ma L.J., van der Does H.C., Borkovich K.A., Coleman J.J., Daboussi M.J.,
RA Di Pietro A., Dufresne M., Freitag M., Grabherr M., Henrissat B.,
RA Houterman P.M., Kang S., Shim W.B., Woloshuk C., Xie X., Xu J.R.,
RA Antoniw J., Baker S.E., Bluhm B.H., Breakspear A., Brown D.W.,
RA Butchko R.A., Chapman S., Coulson R., Coutinho P.M., Danchin E.G.,
RA Diener A., Gale L.R., Gardiner D.M., Goff S., Hammond-Kosack K.E.,
RA Hilburn K., Hua-Van A., Jonkers W., Kazan K., Kodira C.D., Koehrsen M.,
RA Kumar L., Lee Y.H., Li L., Manners J.M., Miranda-Saavedra D., Mukherjee M.,
RA Park G., Park J., Park S.Y., Proctor R.H., Regev A., Ruiz-Roldan M.C.,
RA Sain D., Sakthikumar S., Sykes S., Schwartz D.C., Turgeon B.G.,
RA Wapinski I., Yoder O., Young S., Zeng Q., Zhou S., Galagan J., Cuomo C.A.,
RA Kistler H.C., Rep M.;
RT "Comparative genomics reveals mobile pathogenicity chromosomes in
RT Fusarium.";
RL Nature 464:367-373(2010).
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DR EMBL; DS486012; KYG13832.1; -; Genomic_DNA.
DR RefSeq; XP_018762516.1; XM_018906974.1.
DR STRING; 334819.A0A139YC60; -.
DR GeneID; 30074635; -.
DR KEGG; fvr:FVEG_17759; -.
DR VEuPathDB; FungiDB:FVEG_17759; -.
DR eggNOG; KOG1826; Eukaryota.
DR OrthoDB; 1356198at2759; -.
DR Proteomes; UP000009096; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProt.
DR CDD; cd05392; RasGAP_Neurofibromin_like; 1.
DR Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR10194:SF150; INHIBITORY REGULATOR PROTEIN IRA1-RELATED; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00616; RasGAP; 1.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000009096}.
FT DOMAIN 1173..1366
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT REGION 157..176
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 157..173
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2078 AA; 232824 MW; 38F439D458B52C7D CRC64;
MNCDASLVGC LADRLATRLP HRAGTSGQSL QQDDVLHVTR ATLIELGNTS ISTVIASLLV
LLEDLARPYA SVADHPSHIL ASELYIVAVI ADCCSSHWAS LSQDADVEPA PAPPPLDEVL
VSRLFDAFKH LLEPIPENCI LPAQTLLDQV STRNVSVTRP ESSSVSSDAD SSPPSDERFA
DTLVEMDIHI KTVTEYITTS SWTAAFDYLR NVIYTIRTSI VTQPGVSAPG STQDAERAAL
VVLRLLSFFW VDGPKLGQVI QEICSSFLHF RKPYQNTIAV VSPLLIMRWL DRFPREFVQL
HQLHKRLDGG ADTLFDMAQA ATDNGRRKGL FYPLQTTLLF LLPDVFEVAS NMREAKSSSM
VKKVTFLDGL RKASRNRNEQ AAYCLVSLLR AARHFDVESD SALVSYALDV QDEVRDAVFR
RLTASEYGLF DQDMMTAAFV SLTHLNLDTS VSGFVESCIA SNAPSSFKLA TVQGCTYFAQ
QPYALRYHEL FDAAIPFMRT QLETENAKAV NTTGRQGSER TELVCSILQF LDASPARLLD
DLSKDGSNNS FFKSFLLCVL SENPAVRKLA TGVASRLFQG HLEAYRQFDT GHRFGTKELR
DDIWSRSSKV LLALCESVTS KKDDQSLRDL QDYLEARLLL LKNIPELAKV PEDTPDVINA
SSKLETTLLI SLCSASITTC QLVTSCTGLF IQECSIVDKH VESAKSSASV LRNAEVYREI
SSPAFRFTGL VAFQKRVRGL LRRMQFPTTG IVNAWETAFD RWLHLAKDVS TSTVEIVDGR
ALAEWRNYSG FLASLGGICT ADQAIILEEP ALGGLRWIDR VSSEHSEEPL LTRYLRLSIQ
LLACANVRVR EAMRDVLASE VSPALYYPLF RALESELEVL FTGALAPVEK DQDSEVVFAE
QAASLLRALV ERLESPSDLG AASSVHLGAL TLNFAKFLDG VTDTPNTLRV KIRVCHLCEV
VTKRKEHLNL RDDVRIRNQL LEYIFGWIAR PRSPQHGPGS RQDDTARVQK DLDKACLKSL
ADLTFRLPLQ PSESHTDAGM SEMKSQMFHT YFNRFLSLLN HEPSELTRTD TNLSVTLREE
SASNSDLAIT ILSNLLSANI DVGLKHSLNI GYHDNVEIRT AFVKVLYNIL IQGTEFSNLT
DSAVSEKYEE LLELLTNDLS LAISMAVACP STEVDELTIC LLTVFEQRGM IFELLEALIK
QEIEDTENEA EILRRGCVAT KMLSVYAKWK GASYIRTTLQ KVLERLMLTS KDLDLELDPA
RVSSTEELQK NALQLRIVAK VFIDDICASS SNIPPAFRKI CYTISNAVMP RFPDAKYTAV
GAFIFLRFFC PAIVAPEVEG LVSTAPSKEM RRGLLLIAKV IQNLANNVLF GAKEPYMFPL
NDFLTQNIYH VTTFLREISV PPNQLEVQGT TESFDFGSCV ALHRFLYDHW DHVRQTLISR
ERKDYARTSG DVVRGRSPVL EPLRNLIANL GPPPLAVSWN RPQVSSNSPP LYSRFQNFML
RNAFRSTESF LTARAVYDGG ESKDGLSIIC VILRHIETES IDYDTLMYCY LKIASRLWHR
PFGILIDATC YNGRNEPQDD LFKKLELLTP SELSQNLSRI YVYNMNSAFK RCFRRLLRVC
TKNENGVFNP KNVEYHLIGS LQDLQAHFHL SQLHLPKETI SVVTDTRYVF QPITRLSKSK
GKIEVIIKVG SQFVQVTTTK KQEIFAGFRL GTTVNDIFRL GEVDEAPTSI QTEDDSAFGL
RADNGKIVMY FTSPKKSDVL QTIRGAKAKH GKDSRAHKSV ERLIRPQDVP GTLLNLSLAN
LSSHDHVLRL SSYNLLGALC RAFKFSSASR IVCTKDVSVP LDPTRFVVDI SKELALSEPQ
LTSDFLTEFF VGWESFPDEQ KPLSLAYMAP WLPGLRTNIL ANELDGEKGR ERVAILFRKL
IDVTVQDHSL TFALEQSVWP RIVQDEILLE VFLDELLKSA MSYSAHDESL EVIASIVVGI
GTVTLRGKIL SRLRKALNRS SLRPTKYLPD NAVWSEICVL LRFCLSLSFD NGVQSQLFLP
EIFHIVTCCE HWYSESILVY VLVNTITRMY VVQLMMQI
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