ID A0A140LGK1_DANRE Unreviewed; 624 AA.
AC A0A140LGK1; A0A140LGV0; A0A8N7UZJ0;
DT 11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 2.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=Plastin-2 {ECO:0000313|Ensembl:ENSDARP00000142380, ECO:0000313|RefSeq:NP_571395.2};
GN Name=lcp1 {ECO:0000313|Ensembl:ENSDARP00000142380,
GN ECO:0000313|RefSeq:NP_571395.2, ECO:0000313|ZFIN:ZDB-GENE-991213-5};
GN Synonyms=cb245 {ECO:0000313|RefSeq:NP_571395.2}, fj24b12
GN {ECO:0000313|RefSeq:NP_571395.2}, wu:fj24b12
GN {ECO:0000313|RefSeq:NP_571395.2};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000142380};
RN [1] {ECO:0000313|RefSeq:NP_571395.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_571395.2};
RX PubMed=11468162; DOI=10.1182/blood.V98.3.643;
RA Bennett C.M., Kanki J.P., Rhodes J., Liu T.X., Paw B.H., Kieran M.W.,
RA Langenau D.M., Delahaye-Brown A., Zon L.I., Fleming M.D., Look A.T.;
RT "Myelopoiesis in the zebrafish, Danio rerio.";
RL Blood 98:643-651(2001).
RN [2] {ECO:0000313|RefSeq:NP_571395.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_571395.2};
RX PubMed=14602685; DOI=10.1242/dev.00875;
RA Gering M., Yamada Y., Rabbitts T.H., Patient R.K.;
RT "Lmo2 and Scl/Tal1 convert non-axial mesoderm into haemangioblasts which
RT differentiate into endothelial cells in the absence of Gata1.";
RL Development 130:6187-6199(2003).
RN [3] {ECO:0000313|RefSeq:NP_571395.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_571395.2};
RX PubMed=15327784; DOI=10.1016/j.mod.2004.05.011;
RA Hanaoka R., Ohmori Y., Uyemura K., Hosoya T., Hotta Y., Shirao T.,
RA Okamoto H.;
RT "Zebrafish gcmb is required for pharyngeal cartilage formation.";
RL Mech. Dev. 121:1235-1247(2004).
RN [4] {ECO:0000313|RefSeq:NP_571395.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_571395.2};
RX PubMed=15572152;
RA Leung A.Y., Mendenhall E.M., Kwan T.T., Liang R., Eckfeldt C., Chen E.,
RA Hammerschmidt M., Grindley S., Ekker S.C., Verfaillie C.M.;
RT "Characterization of expanded intermediate cell mass in zebrafish chordin
RT morphant embryos.";
RL Dev. Biol. 277:235-254(2005).
RN [5] {ECO:0000313|RefSeq:NP_571395.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_571395.2};
RX PubMed=15617691; DOI=10.1016/j.ydbio.2004.09.004;
RA Dooley K.A., Davidson A.J., Zon L.I.;
RT "Zebrafish scl functions independently in hematopoietic and endothelial
RT development.";
RL Dev. Biol. 277:522-536(2005).
RN [6] {ECO:0000313|Ensembl:ENSDARP00000142380, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000142380};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [7] {ECO:0000313|Ensembl:ENSDARP00000142380}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000142380};
RG Ensembl;
RL Submitted (MAR-2016) to UniProtKB.
RN [8] {ECO:0000313|RefSeq:NP_571395.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_571395.2};
RX PubMed=28242613;
RA Munch J., Grivas D., Gonzalez-Rajal A., Torregrosa-Carrion R.,
RA de la Pompa J.L.;
RT "Notch signalling restricts inflammation and serpine1 expression in the
RT dynamic endocardium of the regenerating zebrafish heart.";
RL Development 144:1425-1440(2017).
RN [9] {ECO:0000313|RefSeq:NP_571395.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_571395.2};
RX PubMed=28229859;
RA Hasegawa T., Hall C.J., Crosier P.S., Abe G., Kawakami K., Kudo A.,
RA Kawakami A.;
RT "Transient inflammatory response mediated by interleukin-1beta is required
RT for proper regeneration in zebrafish fin fold.";
RL Elife 6:e22716-e22716(2017).
RN [10] {ECO:0000313|RefSeq:NP_571395.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_571395.2};
RX PubMed=28382966;
RA Keightley M.C., Carradice D.P., Layton J.E., Pase L., Bertrand J.Y.,
RA Wittig J.G., Dakic A., Badrock A.P., Cole N.J., Traver D., Nutt S.L.,
RA McCoey J., Buckle A.M., Heath J.K., Lieschke G.J.;
RT "The Pu.1 target gene Zbtb11 regulates neutrophil development through its
RT integrase-like HHCC zinc finger.";
RL Nat. Commun. 8:14911-14911(2017).
RN [11] {ECO:0000313|RefSeq:NP_571395.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_571395.2};
RX PubMed=28182631;
RA Place E.S., Smith J.C.;
RT "Zebrafish atoh8 mutants do not recapitulate morpholino phenotypes.";
RL PLoS ONE 12:E0171143-E0171143(2017).
RN [12] {ECO:0000313|RefSeq:NP_571395.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_571395.2};
RX PubMed=28159303;
RA Pradhan A., Ivarsson P., Ragnvaldsson D., Berg H., Jass J., Olsson P.E.;
RT "Transcriptional responses of zebrafish to complex metal mixtures in
RT laboratory studies overestimates the responses observed with environmental
RT water.";
RL Sci. Total Environ. 584-585:1138-1146(2017).
RN [13] {ECO:0000313|RefSeq:NP_571395.2}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_571395.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; CU914623; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; FO905030; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_571395.2; NM_131320.2.
DR RefSeq; XP_009303302.1; XM_009305027.2.
DR RefSeq; XP_009303303.1; XM_009305028.2.
DR Ensembl; ENSDART00000039235; ENSDARP00000142380; ENSDARG00000023188.
DR Ensembl; ENSDART00000039235.8; ENSDARP00000142380.2; ENSDARG00000023188.10.
DR GeneID; 30583; -.
DR KEGG; dre:30583; -.
DR AGR; ZFIN:ZDB-GENE-991213-5; -.
DR CTD; 3936; -.
DR ZFIN; ZDB-GENE-991213-5; lcp1.
DR OMA; WQLMRKN; -.
DR OrthoDB; 5475188at2759; -.
DR Proteomes; UP000000437; Chromosome 9.
DR Bgee; ENSDARG00000023188; Expressed in motile cell and 60 other cell types or tissues.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0051017; P:actin filament bundle assembly; IEA:InterPro.
DR CDD; cd21327; CH_PLS2_rpt2; 1.
DR CDD; cd21333; CH_PLS2_rpt4; 1.
DR CDD; cd21292; CH_PLS_rpt1; 1.
DR CDD; cd00051; EFh; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 4.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR039959; Fimbrin/Plastin.
DR PANTHER; PTHR19961; FIMBRIN/PLASTIN; 1.
DR PANTHER; PTHR19961:SF35; PLASTIN-2; 1.
DR Pfam; PF00307; CH; 4.
DR Pfam; PF13499; EF-hand_7; 1.
DR SMART; SM00033; CH; 4.
DR SMART; SM00054; EFh; 2.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS00020; ACTININ_2; 2.
DR PROSITE; PS50021; CH; 4.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
PE 1: Evidence at protein level;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A140LGK1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 9..44
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 49..84
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 118..234
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 262..373
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 392..501
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 513..621
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
SQ SEQUENCE 624 AA; 69802 MW; FD3B76B4CDC84C6A CRC64;
MAAAQISAEE MEELREAFTK VDVDGNGHIS TDELNALFKA ANLPLPGYRV REIIQEISRT
MDLNQDGKIT FDEFAKVVHD LKSSEVAKTF RKAINKKEGI CSVAGTSEQS GTQHSYSEEE
KVAFVNWVNK ALEKDPDCQH VLPMDPSTDD LFTAVGDGIV LCKMINLSVP DTIDERTINK
KKLTPFTIQE NLNLALNSAS AIGCHVVNIG AEDLKEGRQH LVLGLLWQVI KIGLFADIEI
SRNEALIALL RDGESLEDLV KLSPEELLLR WANYHLEEAG CPKINNFSSD IKDSKAYYNI
LNQVAPKGDE EGIPAIPIDI SGIREKDDLK RAECMLEQAD RLGCRQFVTA TDVVRGNPKL
NLAYVANLFN KYPALKKPEN QDIDWSSIEG ETREERTFRN WMNSLGVNPR VNHLYVDLAD
ALVIFQLYEK IKVPVDWDKV NKPPYPKLGS NMKKLENCNY AVELGKKEAK FSLVGIAGQD
LNEGNRTLTL ALLWQLMRRY TLNILEDLGD GQKIIDETIV QWVNETLTQA GKGTISGFKD
GSISSSMPVL DLIDAIQPGS IRYDLLKAED LTDEEKLNNA KYAISMARKI GARVYALPED
LVEVKPKMVM TVFACLMARG MRRI
//
