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Database: UniProt
Entry: A0A140LIA1_MOUSE
LinkDB: A0A140LIA1_MOUSE
Original site: A0A140LIA1_MOUSE 
ID   A0A140LIA1_MOUSE        Unreviewed;       503 AA.
AC   A0A140LIA1;
DT   11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT   11-MAY-2016, sequence version 1.
DT   27-SEP-2017, entry version 13.
DE   SubName: Full=Two pore calcium channel protein 2 {ECO:0000313|Ensembl:ENSMUSP00000146736};
DE   Flags: Fragment;
GN   Name=Tpcn2 {ECO:0000313|Ensembl:ENSMUSP00000146736,
GN   ECO:0000313|MGI:MGI:2385297};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000146736};
RN   [1] {ECO:0000313|Ensembl:ENSMUSP00000146736, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000146736,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
RA   She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
RA   Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
RA   Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
RA   Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
RA   Lindblad-Toh K., Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of
RT   the mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2] {ECO:0000313|Ensembl:ENSMUSP00000146736}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000146736};
RG   Ensembl;
RL   Submitted (MAR-2016) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMUSP00000146736}.
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DR   EMBL; AC132081; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC151715; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSMUST00000208148; ENSMUSP00000146736; ENSMUSG00000048677.
DR   MGI; MGI:2385297; Tpcn2.
DR   GeneTree; ENSGT00530000063660; -.
DR   Proteomes; UP000000589; Chromosome 7.
DR   ExpressionAtlas; A0A140LIA1; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:Ensembl.
DR   GO; GO:0072345; F:NAADP-sensitive calcium-release channel activity; IEA:Ensembl.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:Ensembl.
DR   GO; GO:0006939; P:smooth muscle contraction; IEA:Ensembl.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028798; TPC2.
DR   PANTHER; PTHR10037:SF270; PTHR10037:SF270; 1.
DR   Pfam; PF00520; Ion_trans; 2.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000589};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|MaxQB:A0A140LIA1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     36     59       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    118    140       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    179    200       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    247    272       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    396    415       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    427    451       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    463    483       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       46    275       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      391    476       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSMUSP00000146736}.
SQ   SEQUENCE   503 AA;  57469 MW;  E626FCE9B680445A CRC64;
     DQELCIDQAV VFIEDAIKYR SIYHRMDAGS LWLYRWYYSN VCQRVLGFII FLILILAFVE
     VPSSFTKTAD VRYRSQPWQP PCGLTETIEA FCLLAFLVDL SVKGYLVGQA QLQQNLWLLA
     YFMVLVVSVV DWIVSLSLAC EEPLRMRRLL RPFFLLQNSS MMKKTLKCIR WSLPEMASVG
     LLLAIHLCLF TIIGMLLFTI GEKDEAQDQE RLAYFRNLPE ALTSLLVLLT TSNNPDVMIP
     AYTQNRAFAL FFIVFTLIGS LFLMNLLTAI IYNQFRGYLM KSLQTSLFRR RLGARAAYEV
     LASRAGPAGT TPELVGVNPE TFLPVLQKTQ LNKTHKQAIM QKVQSYEGRP MLADEFQKLF
     DEVDKGLAKE RPLKPQYQSP FLQTAQFIFS HHYFDYLGNL VALGNLLSIC VFLVLDSDLL
     PGERDDFVLG ILDYIFILYY LLELLFKVFA LGLPGYLSYH SNVFDGLLTI ILLVSEICTL
     AVYRLPHSGW YVIAENLGTQ LGQ
//
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