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Database: UniProt
Entry: A0A140LJF7_MOUSE
LinkDB: A0A140LJF7_MOUSE
Original site: A0A140LJF7_MOUSE 
ID   A0A140LJF7_MOUSE        Unreviewed;      4858 AA.
AC   A0A140LJF7;
DT   11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT   11-MAY-2016, sequence version 1.
DT   25-OCT-2017, entry version 13.
DE   SubName: Full=Ryanodine receptor 3 {ECO:0000313|Ensembl:ENSMUSP00000147196};
GN   Name=Ryr3 {ECO:0000313|Ensembl:ENSMUSP00000147196,
GN   ECO:0000313|MGI:MGI:99684};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000147196};
RN   [1] {ECO:0000313|Ensembl:ENSMUSP00000147196, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000147196,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
RA   She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
RA   Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
RA   Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
RA   Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
RA   Lindblad-Toh K., Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of
RT   the mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2] {ECO:0000213|PubMed:21183079}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and
RT   expression.";
RL   Cell 143:1174-1189(2010).
RN   [3] {ECO:0000313|Ensembl:ENSMUSP00000147196}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000147196};
RG   Ensembl;
RL   Submitted (MAR-2016) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMUSP00000147196}.
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DR   EMBL; AL672250; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL691423; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL732316; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL929348; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BX649564; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSMUST00000134358; ENSMUSP00000147196; ENSMUSG00000057378.
DR   MGI; MGI:99684; Ryr3.
DR   GeneTree; ENSGT00760000119152; -.
DR   Proteomes; UP000000589; Chromosome 2.
DR   ExpressionAtlas; A0A140LJF7; baseline and differential.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF48371; SSF48371; 8.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000589};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|EPD:A0A140LJF7,
KW   ECO:0000213|MaxQB:A0A140LJF7};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4171   4195       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4399   4419       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4467   4486       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4598   4616       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4659   4680       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4739   4762       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      100    155       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      162    207       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      215    269       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      275    333       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      343    400       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      585    796       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1012   1208       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1254   1466       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3907   3942       EF-hand. {ECO:0000259|PROSITE:PS50222}.
SQ   SEQUENCE   4858 AA;  550833 MW;  B27F412D8BF09B2D CRC64;
     MAEAGEGGED EIQFLRTEDE VVLQCIANIH KEQRKFCLAA EGLGNRLCFL EPTSEAKYIP
     PDLCVCNFVL EQSLSVRALQ EMLANTVENG GEGAAQGGGH RTLLYGHAIL LRHSFSGMYL
     TCLTTSRSQT DKLAFDVGLR EHATGEACWW TIHPASKQRS EGEKVRIGDD LILVSVSSER
     YLHLSISNGS IQVDASFMQT LWNVHPTCSG SSIEEGYLLG GHVVRLFHGH DECLTIPSTD
     QNDSQHRRVF YEAGGAGTRA RSLWRVEPLR ISWSGSNIRW GQAFRLRHLT TGHYLALTED
     QGLLLQDRGK SDTKSTAFSF RASKEIKEKL DSSHKRDMEG MGVPEIKYGD SVCFVQHVAS
     GLWVTYKAQD AKTSRLGPLK RKVILHQEGH MDDGLTLQRC QQEESQAARI IRNTTALFSQ
     FVSGNNRTTA PVALPTEEVL QTLQDLIAYF QPPEDEMQHE DKQNKLRSLK NRQNLFKEEG
     MLALVLNCID RLNIYNSVAH FAGIVREESG MAWKEILNLL YKLLAALIRG NRNNCAQFSN
     NLDWLISKLD RLESSSGILE VLHCILIESP EALNLIAEGH IKSIISLLDK HGRNHKVLDV
     LCSLCLCNGV AVRANQNLIC DNLLPRRNLL LQTRLINDVT SIRPNIFLGV AEGSPQYKKW
     YFELIIDQVE PFLTAEPTHL RVGWASSSGY APYPGGGEGW GGNGVGDDLY SYGFDGLHLW
     SGRIPRAVAS INQHLLKSDD VVSCCLDLGV PSISFRINGQ PVQGMFENFN TDGLFFPVMS
     FSAGVKVRFL MGGRHGEFKF LPPSGYAPCY EALLPKEKMR LEPVKEYKRD ADGVRDLLGT
     TQFLSQASFI PCPIDTSQVV LPLHLEKIRD RLAENIHELW GMNKIELGWT YGKVRDDNKR
     QHPCLVEFSK LPETEKNYNL QMSTETLKTL LALGCHIAHV NPAAEEDLKK VKLPKNYMMS
     NGYKPAPLDL SDVKLLPPQE ILVDKLAENA HNVWAKDRIK QGWTYGIQQD LKNKRNPRLV
     PYALLDERTK KSNRDSLREA VRTFVGYGYN IEPSDQELAD PTVEKVSIDK IRFFRVERSY
     AVKSGKWYFE FEVVTGGDMR VGWARPGCRP DIELGADDQA FVFEGSRGQR WHQGSGYFGR
     TWQPGDVVGC MINLDDASMV FTLNGELLIT NKGSELAFAD YEIENGFVPI CSLGLSQIGR
     MNLGTDASTF KFYTMCGLQE GFEPFAVNMN RDVAVWFSKR LPTFVNVPKD HPHIEVVRID
     GTMDSPPCLK VTHKTFGTQN SNANMIYCRL SMPVECHSSF SHSPCLDSEA FQKRKQMQEI
     LSHTTTQCYY AIRIFAGQDP SCVWVGWVTP DYHLYSEKFD LNKNCTVTVT LGDERGRVHE
     SVKRSNCYMV WGGDIVASSQ RSSRSNVDLE IGCLLDLAMG MLSFSANGKE LGTCYQVEPN
     TKVFPAVFLQ PTSTSLFQFE LGKLKNAMPL SAAIFKSEEK NPTPQCPPRL DVQTIQPVLW
     SRMPSSFLKV ETERVSERHG WVVQCLEPLQ MMALHIPEEN RCVDILELCE QEDLMQFHYH
     TLRLYSAVCA LGNSRVASAL CSHVDLSQLF YAIDNKYLPG LLRSGFYDLL ISIHLANAKE
     RKLMMKNEYI IPITSATRNI RLYPDESKRH GLPGVGLRTC LKPGFRFSTP CFVVTSEDHQ
     KQSPEIPLQI LKTKALSMLT EAVHCSGAHI RDPVGGSVEF QFVPVLKLIG TLLVMGVFDD
     DDVRQILLLI DPSVFGEHSG ETEEGVEKEV THAEEKAVEA GEKACKEAPV KGLLQTRLPE
     SVKLQMCELL SYLCDCELQH RVEAIVAFGD IYVSKLQANQ KFRYNELMQA LNMSAALTAR
     KTREFRSPPQ EQINMLLNFH LGENCPCPEE IREELYDFHE DLLVHCGVPL EEEEEEEEDT
     SWTGKLCALV YKIKGPPKPE KEQPTEEEKP YPTTLKELVS QTMIRWAQEN QIQDAELVRM
     MFNLLRRQYD SIGELLQALR KTYTISQASV NDTINLLAAL GQIRSLLSVR MGREEELLMI
     NGLGDIMNNK VFYQHPNLMR VLGMHETVME VMVNVLGTEK SQIAFPKMVA SCCRFLCYFC
     RISRQNQKAM FEHLSYLLEN SSVGLASPSM RGSTPLDVAA SSVMDNNELA LGLEEPDLEK
     VVTYLAGCGL QSCPMLLARG YPDVGWNPIE GERYLSFLRF AVFVNSESVE ENASVVVKLL
     IRRPECFGPA LRGEGGNGLL AAMQGAIKIS ENPALDLPSQ GYKTEVTQDD GEEEEIVHMG
     NAIMSFYSAL IDLLGRCAPE MHLIQTGKGE AIRIRSILRS LVPTEDLVGI ISIPLKLPSL
     NKDGSVSEPD MAANFCPDHK APMVLFLDRV YGIKDQTFLL HLLEVGFLPD LRASASLDTV
     SLSTTEAALA LNRYLCSAVL PLLTRCAPLF SGTEHCTSLI DSTLQTIYRL SKGRSLTKAQ
     RDTIEECLLA ICNHLRPSML QQLLRRLVFD VPQLSEYCKM PLKLLTNHYE QCWKYYCLPS
     GWGSYGLAVE EELHLTEKLF WGIFDSLSHK KYDLDLFRMA LPCLSAIAGA LPPDYLDTRI
     TATLEKQVSV DADGNFDPKP INTMNFSLPE KLEYIVTKYA EHSHDKWACD KSHSGWKYGI
     SLDENVKTHP LIRPFKTLTE KEKEIYRWPA RESLKTMLAV GWTVERTKEG EALVQQRENE
     KLRCVSQTNQ GNSYSPAPLD LSNVVLSREL QGMVEVVAEN YHNIWAKKKK LELESKGGGS
     HPLLVPYDTL TAKEKFRDRE KAQDLFKFLQ VNGILVSRGM KDLELDASSM EKRFAYKFLK
     KILKYVDAAQ EFIAHLEAIV SSGKTEKSPH DQEIKFFAKV LLPLVDQYFT NHRLYFLSSP
     LKPLSSSGYA SHKEKEMVAS LFCKLAALVR HRISLFGSDS TTMVSCLHIL AQTLDTRTVM
     KSGSELVKAG LRAFFENAAE DLEKTSENLK LGKFTHSRTQ IKGVSQNINY TTVALLPILT
     SIFEHIAQHQ FGVDLLLSDV QVSCYHILCS LYSLGTGKNI YVERQRPALG ECLASLAAAI
     PVAFLEPSLN RHNPLSVFNT KTPRERSILG MPDKVEDMCP DIPQLEGLMK EINDLAESGA
     RYTEMPHVIE VILPMLCNYL SYWWERGPEN LPPSTGPCCT KVTSEHLSLI LGNILKIINN
     NLGIDEASWM KRIAVYAQPI ISKARPDLLR SHFIPTLEKL KKKAVKTVQE EEQLKTDGKG
     DTQEAELLIL DEFAVLCRDL YAFYPMLIRY VDNNRSNWLK SPDPDSDQLF RMVAEVFILW
     CKSHNFKREE QNFVIQNEIN NLAFLTGDSK SKMSKSGGQD QERKKTKRRG DLYSIQTSLI
     VAALKKMLPI GLNMCTPGDQ ELISLAKSRY SCRDTDEEVK EHLRNNLHLQ EKSDDPAVKW
     QLNLYKDVLR NDEPSNPEKT VERVQSISAA LFHLEQVEQP LRSKKAVWHK LLSKQRKRAV
     VACFRMAPLY NLPRHKINNF FLITFQRVWL EKVNEKTQYD RLIPILMKSP RVEDEEEEET
     ERQPDPLHQI ILHFSRNALT ERSKLEDDPL YTSYSSMMAK SCQSGEDEEE EEDKEKTFEE
     KEMEKQKTLY QQARLHERGA AEMVLQMISA SKGEMSPMVV ETLKLGIAIL NGGNAGVQQK
     MLDYLKEKKD AGFFQSLSGL MQSCSVLDLN AFERQNKAEG LGMVTEEGTR EKVLQNDEFT
     QDLFRFLQLL CEGHNSDFQN FLRTQMGNTT TVNIIISTVD YLLRLQESIS DFYWYYSGKD
     IIDESGQHNF SKALAVTKQI FNSLTEYIQG PCIGNQQSLA HSRLWDAVVG FLHVFANMQM
     KLSQDSSQIE LLKELLDLLQ DMVVMLLSLL EGNVVNGTIG KQMVDTLVES STNVEMILKF
     FDMFLKLKDL TSSDTFKEYD PDGKGIISRK EFQKAMEGLK QYTQSEIDFL LSCTEADEND
     MFNYVDFVER FHEPAKDIGF NVAVLLTNLS EHMPNDSRLK SLLDPAESVL NYFEPYLGRI
     EIMGGAKKIE RVYFEISESS RTQWEKPQVK ESKRQFIFDV VNEGGEQEKM ELFVNFCEDT
     IFEMQLASQI SESDSTDRPE EEEEEDEDSA YSIETEGEEE EKSFESASAF TMACVSVKRN
     VTKFLKRATL KNLRKQYRNV KKMSAKELVK VFFSFFWMLF VGLFQLLFTI FGGIFQILWN
     TVFGGGLVEG AKNIRVTKIL GDMPDPTQFG IHDDVIETDR AEVTEPGVTT ELVHFVKGEA
     GDTDIMSDLF GIHSKKEGGL KQGPEVGLGD LSEIIGKDEP PTLESTVRKK RKAQAAEMKA
     VHEAEGKAES EKADMEDREK EDKIKEEGQT DYLWADVTVK KTRRRGQKAE KPEAFMANFF
     KGLEIYQTKL LHYLARNFYN LRFLALFVAF AINFILLFYK VTEEPLEEET EDVANLWNSF
     NDDDEEEAMV FFVLQESTGY MAPTLRALAI VHTIISLVCV VGYYCLKVPL VVFKREKEIA
     RKLEFDGLYI TEQPSEDDIK GQWDRLVINT PSFPNNYWDK FVKRKVINKY GDLYGAERIA
     ELLGLDKNAL DFSPVEEAKA EAASLVSWLS SIDMKYHIWK LGVVFTDNSF LYLAWYTTMS
     VLGHYNNFFF AAHLLDIAMG FKTLRTILSS VTHNGKQLVL TVGLLAVVVY LYTVVAFNFF
     RKFYNKSEDD DEPDMKCDDM MTCYLFHMYV GVRAGGGIGD EIEDPAGDPY EMYRIVFDIT
     FFFFVIVILL AIIQGLIIDA FGELRDQQEQ VREDMETKCF ICGIGNDYFD TTPHGFETHT
     LQEHNLANYL FFLMYLINKD ETEHTGQESY VWKMYQERCW DFFPAGDCFR KQYEDQLG
//
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