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Database: UniProt
Entry: A0A140LJK7_MOUSE
LinkDB: A0A140LJK7_MOUSE
Original site: A0A140LJK7_MOUSE 
ID   A0A140LJK7_MOUSE        Unreviewed;      4868 AA.
AC   A0A140LJK7;
DT   11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT   11-MAY-2016, sequence version 1.
DT   30-AUG-2017, entry version 13.
DE   SubName: Full=Ryanodine receptor 3 {ECO:0000313|Ensembl:ENSMUSP00000147250};
GN   Name=Ryr3 {ECO:0000313|Ensembl:ENSMUSP00000147250,
GN   ECO:0000313|MGI:MGI:99684};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000147250};
RN   [1] {ECO:0000313|Ensembl:ENSMUSP00000147250, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000147250,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
RA   She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
RA   Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
RA   Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
RA   Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
RA   Lindblad-Toh K., Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of
RT   the mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2] {ECO:0000213|PubMed:21183079}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and
RT   expression.";
RL   Cell 143:1174-1189(2010).
RN   [3] {ECO:0000313|Ensembl:ENSMUSP00000147250}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000147250};
RG   Ensembl;
RL   Submitted (MAR-2016) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMUSP00000147250}.
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DR   EMBL; AL672250; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL691423; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL732316; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL929348; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BX649564; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001306085.1; NM_001319156.1.
DR   UniGene; Mm.436657; -.
DR   SMR; A0A140LJK7; -.
DR   Ensembl; ENSMUST00000208290; ENSMUSP00000147250; ENSMUSG00000057378.
DR   GeneID; 20192; -.
DR   KEGG; mmu:20192; -.
DR   CTD; 6263; -.
DR   MGI; MGI:99684; Ryr3.
DR   GeneTree; ENSGT00760000119152; -.
DR   KO; K04963; -.
DR   Proteomes; UP000000589; Chromosome 2.
DR   ExpressionAtlas; A0A140LJK7; baseline and differential.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000589};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|EPD:A0A140LJK7,
KW   ECO:0000213|MaxQB:A0A140LJK7};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4181   4205       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4409   4429       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4477   4496       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4608   4626       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4669   4690       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4749   4772       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      100    155       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      162    207       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      215    269       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      275    333       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      343    400       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      585    796       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1012   1208       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1254   1466       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3917   3952       EF-hand. {ECO:0000259|PROSITE:PS50222}.
SQ   SEQUENCE   4868 AA;  551886 MW;  5F2D772A0D3CB1D4 CRC64;
     MAEAGEGGED EIQFLRTEDE VVLQCIANIH KEQRKFCLAA EGLGNRLCFL EPTSEAKYIP
     PDLCVCNFVL EQSLSVRALQ EMLANTVENG GEGAAQGGGH RTLLYGHAIL LRHSFSGMYL
     TCLTTSRSQT DKLAFDVGLR EHATGEACWW TIHPASKQRS EGEKVRIGDD LILVSVSSER
     YLHLSISNGS IQVDASFMQT LWNVHPTCSG SSIEEGYLLG GHVVRLFHGH DECLTIPSTD
     QNDSQHRRVF YEAGGAGTRA RSLWRVEPLR ISWSGSNIRW GQAFRLRHLT TGHYLALTED
     QGLLLQDRGK SDTKSTAFSF RASKEIKEKL DSSHKRDMEG MGVPEIKYGD SVCFVQHVAS
     GLWVTYKAQD AKTSRLGPLK RKVILHQEGH MDDGLTLQRC QQEESQAARI IRNTTALFSQ
     FVSGNNRTTA PVALPTEEVL QTLQDLIAYF QPPEDEMQHE DKQNKLRSLK NRQNLFKEEG
     MLALVLNCID RLNIYNSVAH FAGIVREESG MAWKEILNLL YKLLAALIRG NRNNCAQFSN
     NLDWLISKLD RLESSSGILE VLHCILIESP EALNLIAEGH IKSIISLLDK HGRNHKVLDV
     LCSLCLCNGV AVRANQNLIC DNLLPRRNLL LQTRLINDVT SIRPNIFLGV AEGSPQYKKW
     YFELIIDQVE PFLTAEPTHL RVGWASSSGY APYPGGGEGW GGNGVGDDLY SYGFDGLHLW
     SGRIPRAVAS INQHLLKSDD VVSCCLDLGV PSISFRINGQ PVQGMFENFN TDGLFFPVMS
     FSAGVKVRFL MGGRHGEFKF LPPSGYAPCY EALLPKEKMR LEPVKEYKRD ADGVRDLLGT
     TQFLSQASFI PCPIDTSQVV LPLHLEKIRD RLAENIHELW GMNKIELGWT YGKVRDDNKR
     QHPCLVEFSK LPETEKNYNL QMSTETLKTL LALGCHIAHV NPAAEEDLKK VKLPKNYMMS
     NGYKPAPLDL SDVKLLPPQE ILVDKLAENA HNVWAKDRIK QGWTYGIQQD LKNKRNPRLV
     PYALLDERTK KSNRDSLREA VRTFVGYGYN IEPSDQELAD PTVEKVSIDK IRFFRVERSY
     AVKSGKWYFE FEVVTGGDMR VGWARPGCRP DIELGADDQA FVFEGSRGQR WHQGSGYFGR
     TWQPGDVVGC MINLDDASMV FTLNGELLIT NKGSELAFAD YEIENGFVPI CSLGLSQIGR
     MNLGTDASTF KFYTMCGLQE GFEPFAVNMN RDVAVWFSKR LPTFVNVPKD HPHIEVVRID
     GTMDSPPCLK VTHKTFGTQN SNANMIYCRL SMPVECHSSF SHSPCLDSEA FQKRKQMQEI
     LSHTTTQCYY AIRIFAGQDP SCVWVGWVTP DYHLYSEKFD LNKNCTVTVT LGDERGRVHE
     SVKRSNCYMV WGGDIVASSQ RSSRSNVDLE IGCLLDLAMG MLSFSANGKE LGTCYQVEPN
     TKVFPAVFLQ PTSTSLFQFE LGKLKNAMPL SAAIFKSEEK NPTPQCPPRL DVQTIQPVLW
     SRMPSSFLKV ETERVSERHG WVVQCLEPLQ MMALHIPEEN RCVDILELCE QEDLMQFHYH
     TLRLYSAVCA LGNSRVASAL CSHVDLSQLF YAIDNKYLPG LLRSGFYDLL ISIHLANAKE
     RKLMMKNEYI IPITSATRNI RLYPDESKRH GLPGVGLRTC LKPGFRFSTP CFVVTSEDHQ
     KQSPEIPLQI LKTKALSMLT EAVHCSGAHI RDPVGGSVEF QFVPVLKLIG TLLVMGVFDD
     DDVRQILLLI DPSVFGEHSG ETEEGVEKEV THAEEKAVEA GEKACKEAPV KGLLQTRLPE
     SVKLQMCELL SYLCDCELQH RVEAIVAFGD IYVSKLQANQ KFRYNELMQA LNMSAALTAR
     KTREFRSPPQ EQINMLLNFH LGENCPCPEE IREELYDFHE DLLVHCGVPL EEEEEEEEDT
     SWTGKLCALV YKIKGPPKPE KEQPTEEEKP YPTTLKELVS QTMIRWAQEN QIQDAELVRM
     MFNLLRRQYD SIGELLQALR KTYTISQASV NDTINLLAAL GQIRSLLSVR MGREEELLMI
     NGLGDIMNNK VFYQHPNLMR VLGMHETVME VMVNVLGTEK SQIAFPKMVA SCCRFLCYFC
     RISRQNQKAM FEHLSYLLEN SSVGLASPSM RGSTPLDVAA SSVMDNNELA LGLEEPDLEK
     VVTYLAGCGL QSCPMLLARG YPDVGWNPIE GERYLSFLRF AVFVNSESVE ENASVVVKLL
     IRRPECFGPA LRGEGGNGLL AAMQGAIKIS ENPALDLPSQ GYKTEVTQDD GEEEEIVHMG
     NAIMSFYSAL IDLLGRCAPE MHLIQTGKGE AIRIRSILRS LVPTEDLVGI ISIPLKLPSL
     NKDGSVSEPD MAANFCPDHK APMVLFLDRV YGIKDQTFLL HLLEVGFLPD LRASASLDTV
     SLSTTEAALA LNRYLCSAVL PLLTRCAPLF SGTEHCTSLI DSTLQTIYRL SKGRSLTKAQ
     RDTIEECLLA ICNHLRPSML QQLLRRLVFD VPQLSEYCKM PLKLLTNHYE QCWKYYCLPS
     GWGSYGLAVE EELHLTEKLF WGIFDSLSHK KYDLDLFRMA LPCLSAIAGA LPPDYLDTRI
     TATLEKQVSV DADGNFDPKP INTMNFSLPE KLEYIVTKYA EHSHDKWACD KSHSGWKYGI
     SLDENVKTHP LIRPFKTLTE KEKEIYRWPA RESLKTMLAV GWTVERTKEG EALVQQRENE
     KLRCVSQTNQ GNSYSPAPLD LSNVVLSREL QGMVEVVAEN YHNIWAKKKK LELESKGGGS
     HPLLVPYDTL TAKEKFRDRE KAQDLFKFLQ VNGILVSRGM KDLELDASSM EKRFAYKFLK
     KILKYVDAAQ EFIAHLEAIV SSGKTEKSPH DQEIKFFAKV LLPLVDQYFT NHRLYFLSSP
     LKPLSSSGYA SHKEKEMVAS LFCKLAALVR HRISLFGSDS TTMVSCLHIL AQTLDTRTVM
     KSGSELVKAG LRAFFENAAE DLEKTSENLK LGKFTHSRTQ IKGVSQNINY TTVALLPILT
     SIFEHIAQHQ FGVDLLLSDV QVSCYHILCS LYSLGTGKNI YVERQRPALG ECLASLAAAI
     PVAFLEPSLN RHNPLSVFNT KTPRERSILG MPDKVEDMCP DIPQLEGLMK EINDLAESGA
     RYTEMPHVIE VILPMLCNYL SYWWERGPEN LPPSTGPCCT KVTSEHLSLI LGNILKIINN
     NLGIDEASWM KRIAVYAQPI ISKARPDLLR SHFIPTLEKL KKKAVKTVQE EEQLKTDGKG
     DTQEAELLIL DEFAVLCRDL YAFYPMLIRY VDNNRSNWLK SPDPDSDQLF RMVAEVFILW
     CKSHNFKREE QNFVIQNEIN NLAFLTGDSK SKMSKAMQVK SGGQDQERKK TKRRGDLYSI
     QTSLIVAALK KMLPIGLNMC TPGDQELISL AKSRYSCRDT DEEVKEHLRN NLHLQEKSDD
     PAVKWQLNLY KDVLRNDEPS NPEKTVERVQ SISAALFHLE QVEQPLRSKK AVWHKLLSKQ
     RKRAVVACFR MAPLYNLPRH RSINLFLHGY QRFWIETEAH FFEEKLVQDL AKSPRVEDEE
     EEETERQPDP LHQIILHFSR NALTERSKLE DDPLYTSYSS MMAKSCQSGE DEEEEEDKEK
     TFEEKEMEKQ KTLYQQARLH ERGAAEMVLQ MISASKGEMS PMVVETLKLG IAILNGGNAG
     VQQKMLDYLK EKKDAGFFQS LSGLMQSCSV LDLNAFERQN KAEGLGMVTE EGTLIVRERG
     EKVLQNDEFT QDLFRFLQLL CEGHNSDFQN FLRTQMGNTT TVNIIISTVD YLLRLQESIS
     DFYWYYSGKD IIDESGQHNF SKALAVTKQI FNSLTEYIQG PCIGNQQSLA HSRLWDAVVG
     FLHVFANMQM KLSQDSSQIE LLKELLDLLQ DMVVMLLSLL EGNVVNGTIG KQMVDTLVES
     STNVEMILKF FDMFLKLKDL TSSDTFKEYD PDGKGIISRK EFQKAMEGLK QYTQSEIDFL
     LSCTEADEND MFNYVDFVER FHEPAKDIGF NVAVLLTNLS EHMPNDSRLK SLLDPAESVL
     NYFEPYLGRI EIMGGAKKIE RVYFEISESS RTQWEKPQVK ESKRQFIFDV VNEGGEQEKM
     ELFVNFCEDT IFEMQLASQI SESDSTDRPE EEEEEDEDSA YSIETEGEEE EKSFESASAF
     TMACVSVKRN VTKFLKRATL KNLRKQYRNV KKMSAKELVK VFFSFFWMLF VGLFQLLFTI
     FGGIFQILWN TVFGGGLVEG AKNIRVTKIL GDMPDPTQFG IHDDVIETDR AEVTEPGVTT
     ELVHFVKGEA GDTDIMSDLF GIHSKKEGGL KQGPEVGLGD LSEIIGKDEP PTLESTVRKK
     RKAQAAEMKA VHEAEGKAES EKADMEDREK EDKIKEEGQT DYLWADVTVK KTRRRGQKAE
     KPEAFMANFF KGLEIYQTKL LHYLARNFYN LRFLALFVAF AINFILLFYK VTEEPLEEET
     EDVANLWNSF NDDDEEEAMV FFVLQESTGY MAPTLRALAI VHTIISLVCV VGYYCLKVPL
     VVFKREKEIA RKLEFDGLYI TEQPSEDDIK GQWDRLVINT PSFPNNYWDK FVKRKVINKY
     GDLYGAERIA ELLGLDKNAL DFSPVEEAKA EAASLVSWLS SIDMKYHIWK LGVVFTDNSF
     LYLAWYTTMS VLGHYNNFFF AAHLLDIAMG FKTLRTILSS VTHNGKQLVL TVGLLAVVVY
     LYTVVAFNFF RKFYNKSEDD DEPDMKCDDM MTCYLFHMYV GVRAGGGIGD EIEDPAGDPY
     EMYRIVFDIT FFFFVIVILL AIIQGLIIDA FGELRDQQEQ VREDMETKCF ICGIGNDYFD
     TTPHGFETHT LQEHNLANYL FFLMYLINKD ETEHTGQESY VWKMYQERCW DFFPAGDCFR
     KQYEDQLG
//
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