ID A0A140T893_BOVIN Unreviewed; 701 AA.
AC A0A140T893;
DT 11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT 11-MAY-2016, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=Lutropin-choriogonadotropic hormone receptor {ECO:0000256|ARBA:ARBA00022266, ECO:0000256|RuleBase:RU361222};
GN Name=LHCGR {ECO:0000256|RuleBase:RU361222,
GN ECO:0000313|Ensembl:ENSBTAP00000022047.5,
GN ECO:0000313|VGNC:VGNC:111941};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000022047.5, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000022047.5, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000022047.5,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000022047.5}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000022047.5};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Receptor for lutropin-choriogonadotropic hormone. The
CC activity of this receptor is mediated by G proteins which activate
CC adenylate cyclase. {ECO:0000256|RuleBase:RU361222}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651,
CC ECO:0000256|RuleBase:RU361222}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU361222}.
CC Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC FSH/LSH/TSH subfamily. {ECO:0000256|RuleBase:RU361222}.
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DR AlphaFoldDB; A0A140T893; -.
DR SMR; A0A140T893; -.
DR Ensembl; ENSBTAT00000022047.6; ENSBTAP00000022047.5; ENSBTAG00000016573.6.
DR VEuPathDB; HostDB:ENSBTAG00000016573; -.
DR VGNC; VGNC:111941; LHCGR.
DR GeneTree; ENSGT00940000157364; -.
DR InParanoid; A0A140T893; -.
DR OMA; TACIERD; -.
DR Reactome; R-BTA-375281; Hormone ligand-binding receptors.
DR Reactome; R-BTA-418555; G alpha (s) signalling events.
DR Proteomes; UP000009136; Chromosome 11.
DR Bgee; ENSBTAG00000016573; Expressed in diaphragm and 32 other cell types or tissues.
DR ExpressionAtlas; A0A140T893; baseline.
DR GO; GO:0034451; C:centriolar satellite; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0038106; F:choriogonadotropin hormone binding; IEA:Ensembl.
DR GO; GO:0035472; F:choriogonadotropin hormone receptor activity; IEA:Ensembl.
DR GO; GO:0008528; F:G protein-coupled peptide receptor activity; IBA:GO_Central.
DR GO; GO:0004964; F:luteinizing hormone receptor activity; IBA:GO_Central.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0071373; P:cellular response to luteinizing hormone stimulus; IEA:Ensembl.
DR GO; GO:0050890; P:cognition; IEA:Ensembl.
DR GO; GO:0046544; P:development of secondary male sexual characteristics; IEA:Ensembl.
DR GO; GO:0009755; P:hormone-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0042700; P:luteinizing hormone signaling pathway; IBA:GO_Central.
DR GO; GO:0008584; P:male gonad development; IBA:GO_Central.
DR GO; GO:0001541; P:ovarian follicle development; IBA:GO_Central.
DR GO; GO:0022602; P:ovulation cycle process; IBA:GO_Central.
DR GO; GO:0007200; P:phospholipase C-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0032962; P:positive regulation of inositol trisphosphate biosynthetic process; IEA:Ensembl.
DR GO; GO:0090030; P:regulation of steroid hormone biosynthetic process; IEA:Ensembl.
DR GO; GO:0072520; P:seminiferous tubule development; IEA:Ensembl.
DR GO; GO:0007283; P:spermatogenesis; IEA:Ensembl.
DR GO; GO:0060065; P:uterus development; IEA:Ensembl.
DR CDD; cd15359; 7tmA_LHCGR; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR002131; Gphrmn_rcpt_fam.
DR InterPro; IPR026906; LRR_5.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002273; LSH_rcpt.
DR PANTHER; PTHR24372; GLYCOPROTEIN HORMONE RECEPTOR; 1.
DR PANTHER; PTHR24372:SF1; LUTROPIN-CHORIOGONADOTROPIC HORMONE RECEPTOR; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR Pfam; PF13306; LRR_5; 2.
DR PRINTS; PR00373; GLYCHORMONER.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01144; LSHRECEPTOR.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU361222};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040,
KW ECO:0000256|RuleBase:RU361222};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361222};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU361222};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|RuleBase:RU361222};
KW Sulfation {ECO:0000256|ARBA:ARBA00022641};
KW Transducer {ECO:0000256|ARBA:ARBA00023224, ECO:0000256|RuleBase:RU361222};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361222};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361222}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|RuleBase:RU361222"
FT CHAIN 27..701
FT /note="Lutropin-choriogonadotropic hormone receptor"
FT /evidence="ECO:0000256|RuleBase:RU361222"
FT /id="PRO_5007230467"
FT TRANSMEM 366..387
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361222"
FT TRANSMEM 399..420
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361222"
FT TRANSMEM 443..464
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361222"
FT TRANSMEM 485..508
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361222"
FT TRANSMEM 528..553
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361222"
FT TRANSMEM 574..596
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361222"
FT TRANSMEM 608..628
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361222"
FT DOMAIN 378..625
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
SQ SEQUENCE 701 AA; 78456 MW; D70AE862EB265CCF CRC64;
MGRPSLALRL LLALLLLPPP APLLWALRPA PCPEPCSCPP DGALRCPGPQ AGLSRLSLTY
LPIKVIPSQA FRGLNEVIKI EISQSDSLEK IEANAFDNLL NLSEILIQNT KNLVHIEAGA
FTNLPRLKYL SICNTGIHKL PDVTKIFSSE FNFILEICDN LHITTIPRNA FQGMNNESIT
LKLYGNGFEE IQSHAFNGTT LISLELKENA RLEKMHNDAF RGATGPSILD ISSTQLQALP
TYGLESIQTL IATSSYSLKK LPSREKFTNL LDATLTYPSH CCAFRNLPTN EQNFSFSIFK
NFSKQCESTA RRPNNETLYS AIFAESELSG WDYDYGFCLP KTLQCAPEPD AFNPCEDIMG
YNFLRVLIWL INILAITGNV TVLFVLLTSR YKLTVPRFLM CNLSFADFCM GLYLLLIASV
DAQTKGQYYN HAIDWQTGSG CSAAGFFTVF ASELSVYTLT VITLERWHTI TYAIQLDQKL
RLKHAIPVML GGWLFSTLIA VLPLVGVSNY MKVSICLPMD VESTLSQVYI LTILILNVMA
FIIICACYIK IYFAVQNPEL MATNKDTKIA KKMAVLIFTD FTCMAPISFF AISAAFKVPL
ITVTNSKVLL VLFYPVNSCA NPFLYAIFTK AFQRDFFLLL SKFGCCKYRA ELYRRKDFSA
YISNCKNGFT GSNKPSRSTF KLTTLQCQYS AVLDKTCYKE C
//
