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Database: UniProt
Entry: A0A143HHG7_9GAMM
LinkDB: A0A143HHG7_9GAMM
Original site: A0A143HHG7_9GAMM 
ID   A0A143HHG7_9GAMM        Unreviewed;       503 AA.
AC   A0A143HHG7;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   25-OCT-2017, entry version 14.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=A3224_00005 {ECO:0000313|EMBL:AMX01174.1}, SAMN05660479_01323
GN   {ECO:0000313|EMBL:SFC18453.1};
OS   Microbulbifer thermotolerans.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Cellvibrionales;
OC   Microbulbiferaceae; Microbulbifer.
OX   NCBI_TaxID=252514 {ECO:0000313|EMBL:AMX01174.1, ECO:0000313|Proteomes:UP000076077};
RN   [1] {ECO:0000313|EMBL:AMX01174.1, ECO:0000313|Proteomes:UP000076077}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DAU221 {ECO:0000313|EMBL:AMX01174.1,
RC   ECO:0000313|Proteomes:UP000076077};
RA   Ploux O.;
RL   Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:SFC18453.1, ECO:0000313|Proteomes:UP000181967}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 19189 {ECO:0000313|EMBL:SFC18453.1,
RC   ECO:0000313|Proteomes:UP000181967};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CP014864; AMX01174.1; -; Genomic_DNA.
DR   EMBL; FOKT01000003; SFC18453.1; -; Genomic_DNA.
DR   RefSeq; WP_067149794.1; NZ_FOKT01000003.1.
DR   EnsemblBacteria; AMX01174; AMX01174; A3224_00005.
DR   KEGG; mthd:A3224_00005; -.
DR   KO; K02313; -.
DR   Proteomes; UP000076077; Chromosome.
DR   Proteomes; UP000181967; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000076077,
KW   ECO:0000313|Proteomes:UP000181967};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000076077}.
FT   DOMAIN      200    409       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      411    480       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     208    215       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   503 AA;  56031 MW;  10D261B01F910F28 CRC64;
     MSESVWKQCA SCLQDELPAQ QFNTWIRPLR VNPASSAGEL RLLAPNRFVL DWVADKFLNR
     IRELLQEFSG GQPIQVVLEI TERRPARFQR TRVAARQSAA TAQPAPARGF SAARVAPHPA
     VQEEGSAEQI TSGELALTDL RGGGAQRPGA EPVRNVEVEG AIKHGSSLNR NFTFKSFVEG
     KSNQLGLAAA QQIADNPGGA YNPLFIYGGV GLGKTHLMHA VGNALVERNP NAKVVYLHSE
     RFVADMVKAL QLNAISDFKR YYRSVDALLI DDIQFFAGKE RSQEEFFHTF NALLEGGQQI
     ILTCDRYPKE IDGLEERLKS RFGWGLTVAV EPPELETRVA ILMKKAEQVG VDLPHDSAFF
     IAQRIRSNVR ELEGALRRVI ANAQFTGRPI DDLLVREALK DLLALQDRLV SVDNIQRVVA
     EYYKIKVSDL LSKRRSRSVA RPRQVAMSLA KELTNHSLPE IGDAFGGRDH TTVLHACRKI
     RELQETDADI REDVKLLTRS LTT
//
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