ID A0A143Y8K3_9LACT Unreviewed; 863 AA.
AC A0A143Y8K3;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN ORFNames=TR210_227 {ECO:0000313|EMBL:CZQ82539.1};
OS Trichococcus ilyis.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Carnobacteriaceae;
OC Trichococcus.
OX NCBI_TaxID=640938 {ECO:0000313|EMBL:CZQ82539.1, ECO:0000313|Proteomes:UP000076878};
RN [1] {ECO:0000313|EMBL:CZQ82539.1, ECO:0000313|Proteomes:UP000076878}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Trichococcus_R210 {ECO:0000313|EMBL:CZQ82539.1};
RA Wen L., He K., Yang H.;
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
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DR EMBL; FJNB01000001; CZQ82539.1; -; Genomic_DNA.
DR RefSeq; WP_068620702.1; NZ_FNYT01000001.1.
DR AlphaFoldDB; A0A143Y8K3; -.
DR STRING; 640938.TR210_227; -.
DR OrthoDB; 9802448at2; -.
DR Proteomes; UP000076878; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 2.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}.
FT DOMAIN 685..701
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT BINDING 611..618
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 863 AA; 97427 MW; 34E19F2B45E2FB00 CRC64;
MPQKTKHTPM MEQYLAIKAQ YPDAFLFYRL GDFYELFHDD AMKAAKLLEI TLTSRNKNAD
EPIPMCGVPF HAAADYIRRL VEMGHKVAVC EQMEDAKQTK GMVRREVVQV ITPGTFLNEN
SSESKTNNYL ASVIRIEADG FALGYVDIGT GELKVTLLAN EDAVFNELQT LPFKEIVLDT
KTADGLTEKL QKQFGILVSI QTELVQETSF RDLVADLPQQ AEKDVLILLL SYLSDTQKRS
LSHLQKAAAY QTDAFLKMDT YARRNLELAT SIRTQQKKGS LLWTLDETKT AMGGRMLKQW
LEKPLINLSD ILARQRKVES LVNHYFERMD INDALTSVYD LERLVARVAL GNVNGRDLIQ
LKTSLRQIPG LVQAIAAIDE PDIWQDVIDK LEAYPDVTEL IERAITDNPP IQITEGNLIR
DGYDEQLDRY RDAMNNGKLW IAMLQKEERE KTGIKTLKIG YNRIFGYYIE VTKANLAALP
EGTYERKQTL ANAERFVTPA LKEKETLILE AEEKSVQLEH ELFIALREEI KGYSRQLQAL
AKLVAEIDVL QAFAHVSEAY HFTKPELSNS DRNLTVKEGR HPVVERVIGK DKFVPNSISM
DEDNHILLIT GPNMSGKSTY MRQVALIVIL AQMGCFVPAE KARLPIFDQI FTRIGAADDL
YSGQSTFMVE MVETNQALRF ATDKSLILFD EIGRGTATYD GMALAEAILR YIDRTIKGKT
LFSTHYHELT QLEAELAGTK NVHVGAIEKD GELVFLHKLM TGPADKSYGL HVAKLAGMPD
ELISEAQVIL NSLNEQHELH SGLSVPALED TVEQLALFQE NTMHPNEKHI LDELSDLALE
DCTPMQAMLL LDGWKKLLKS QKK
//
