ID A0A147ED35_9MICO Unreviewed; 1212 AA.
AC A0A147ED35;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE RecName: Full=Transcription-repair-coupling factor {ECO:0000256|HAMAP-Rule:MF_00969};
DE Short=TRCF {ECO:0000256|HAMAP-Rule:MF_00969};
DE EC=3.6.4.- {ECO:0000256|HAMAP-Rule:MF_00969};
GN Name=mfd {ECO:0000256|HAMAP-Rule:MF_00969};
GN ORFNames=NS354_11345 {ECO:0000313|EMBL:KTR82327.1};
OS Leucobacter chromiiresistens.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Microbacteriaceae;
OC Leucobacter.
OX NCBI_TaxID=1079994 {ECO:0000313|EMBL:KTR82327.1, ECO:0000313|Proteomes:UP000070810};
RN [1] {ECO:0000313|EMBL:KTR82327.1, ECO:0000313|Proteomes:UP000070810}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NS354 {ECO:0000313|EMBL:KTR82327.1,
RC ECO:0000313|Proteomes:UP000070810};
RX PubMed=26793183;
RA Midha S., Bansal K., Sharma S., Kumar N., Patil P.P., Chaudhry V.,
RA Patil P.B.;
RT "Genomic Resource of Rice Seed Associated Bacteria.";
RL Front. Microbiol. 6:1551-1551(2016).
CC -!- FUNCTION: Couples transcription and DNA repair by recognizing RNA
CC polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent
CC release of RNAP and its truncated transcript from the DNA, and
CC recruitment of nucleotide excision repair machinery to the damaged
CC site. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the helicase family.
CC RecG subfamily. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the UvrB family.
CC {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KTR82327.1}.
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DR EMBL; LDRK01000099; KTR82327.1; -; Genomic_DNA.
DR RefSeq; WP_058594585.1; NZ_LDRK01000099.1.
DR AlphaFoldDB; A0A147ED35; -.
DR PATRIC; fig|1079994.3.peg.2663; -.
DR OrthoDB; 9804325at2; -.
DR Proteomes; UP000070810; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR GO; GO:0000716; P:transcription-coupled nucleotide-excision repair, DNA damage recognition; IEA:UniProtKB-UniRule.
DR CDD; cd17991; DEXHc_TRCF; 1.
DR Gene3D; 2.40.10.170; -; 1.
DR Gene3D; 3.40.50.11180; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.30.2060.10; Penicillin-binding protein 1b domain; 1.
DR Gene3D; 3.90.1150.50; Transcription-repair-coupling factor, D7 domain; 1.
DR HAMAP; MF_00969; TRCF; 1.
DR InterPro; IPR003711; CarD-like/TRCF_RID.
DR InterPro; IPR036101; CarD-like/TRCF_RID_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR004576; Mfd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047112; RecG/Mfd.
DR InterPro; IPR037235; TRCF-like_C_D7.
DR InterPro; IPR005118; TRCF_C.
DR InterPro; IPR041471; UvrB_inter.
DR NCBIfam; TIGR00580; mfd; 1.
DR PANTHER; PTHR47964; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR PANTHER; PTHR47964:SF1; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR Pfam; PF02559; CarD_TRCF_RID; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF03461; TRCF; 1.
DR Pfam; PF17757; UvrB_inter; 1.
DR SMART; SM01058; CarD_TRCF; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00982; TRCF; 1.
DR SUPFAM; SSF141259; CarD-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR SUPFAM; SSF143517; TRCF domain-like; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00969};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Reference proteome {ECO:0000313|Proteomes:UP000070810}.
FT DOMAIN 663..824
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 849..999
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 1212 AA; 131428 MW; 7851C2C46CC8E7EC CRC64;
MTLRGLDRLL EASESFAAAL DASGGDAEFS IAEGLRAPLI AGLLRRRRAA GDRGALLVVA
ATSREADAVR SALASLLPDA ITAEFPAWET LPHERLSPSA ETVGRRAEAL RLLREYDGET
PLVMVASVRA ALQPVSPHAA LAEPVVLSAG RSSDGLEAIA RRLVEYAYTR VDMVTRRGEF
AVRGGILDVF PPTAEQAVRV DFFGDEIDQI KRFAVSDQRS AGEPLDAVEL WPARELLLTD
EVRERAAALL PRFPALGSLL EKMSEGIAVE GMESLLPQLV PGLSPLTALL PDGGAVLVVS
PERVASRAVS LADTNREFLE AAWQAATAGA DAPVPVDDSG MLSMEALRAA SRARPWWSVS
NFVRDEPAPG GDPFDADTVD DPAVVAVHGG AFPRPAQAGD ATGAAIRLIG ERLRDGWHAV
VTAQGIGLVE RARDVLAEAG AAARIVDELP ETWEDGIVYL VTGTAWSGFE SGEARLLLAT
EAEFFGRSAG SQAAAGQKLA KRRGKNVVDP LKLVAGDYVV HETHGIGQFV ELTQRMVPTG
IGRDATKALR EYLVLEYAST KRGMPRDKLY VPTDQLDQLS RYVGGEAPTL SKMGGSDWAS
AKKKARKAVR DIAVELVKLY SARVASKGFA FSADTPWQHE LEEAFPYAET MDQLTTIDEV
KRDMERTIPM DRLIAGDVGF GKTEVAVRAA FKAVQDGKQV AMLVPTTLLV TQHLETFQNR
FAGFPVRLRP LSRFQSEKES RDTIEGLAAG TVDVVIGTHR LLAESVRYKD LGLVIIDEEQ
RFGVEHKDAL KKLKTNVDIL AMSATPIPRT LEMAVTGIRE MSTLATAPED RHPILTFVGP
RSDKQITAAI RRELLREGQV FFVHNRVQSI TRVANQIAEL VPEARVAVAH GKLGEHQLEQ
VVQDFWERKF DVLVSTTIIE TGLDIANANT IIIDNADKYG LSQLHQLRGR VGRSRERAYA
YFLYDPDKPL TEHAHERLDT LATNNELGSG MQVALKDLEL RGAGNLLGGE QSGHIAGVGF
DLYLRMIGEA VNSFKGEETT GTTELVLELP VDAHIPEDYV ESERLRLEAY QKFSAASHPQ
APEEHVSLVL EELTDRYGAP PVEVERLAAV SALRRRASRL GLSKVVAAGP ALRIEPVELL
DSRRMRMNRM YPGARYVEAS KSLQIPLPGG TASSRSPLAG VGQKLVGDEG DIVAWTGRVL
ATLLEADAPA EA
//
