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Database: UniProt
Entry: A0A150YAT0_9FIRM
LinkDB: A0A150YAT0_9FIRM
Original site: A0A150YAT0_9FIRM 
ID   A0A150YAT0_9FIRM        Unreviewed;       469 AA.
AC   A0A150YAT0;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   27-SEP-2017, entry version 12.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=AXF09_04670 {ECO:0000313|EMBL:KYG88063.1};
OS   Ruminococcus sp. DSM 100440.
OC   Bacteria; Firmicutes; Clostridia; Clostridiales; Ruminococcaceae;
OC   Ruminococcus.
OX   NCBI_TaxID=1671366 {ECO:0000313|EMBL:KYG88063.1, ECO:0000313|Proteomes:UP000075299};
RN   [1] {ECO:0000313|EMBL:KYG88063.1, ECO:0000313|Proteomes:UP000075299}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 100440 {ECO:0000313|EMBL:KYG88063.1,
RC   ECO:0000313|Proteomes:UP000075299};
RX   PubMed=26946362;
RA   Hynonen U., Rasinkangas P., Satokari R., Paulin L., de Vos W.M.,
RA   Pietila T.E., Kant R., Palva A.;
RT   "Isolation and whole genome sequencing of a Ruminococcus-like
RT   bacterium, associated with irritable bowel syndrome.";
RL   Anaerobe 39:60-67(2016).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731907}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KYG88063.1}.
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DR   EMBL; LFIL01000004; KYG88063.1; -; Genomic_DNA.
DR   RefSeq; WP_048621182.1; NZ_LFIL01000004.1.
DR   EnsemblBacteria; KYG88063; KYG88063; AXF09_04670.
DR   Proteomes; UP000075299; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000075299};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000075299}.
FT   DOMAIN      155    289       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      376    445       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     163    170       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   469 AA;  53214 MW;  E6211A634549B571 CRC64;
     MDIVTEKWNE IIENLRLEHS LSDVSFKTWI LPLKVYDVIE NTVYILVTLD GTGDYIDYIE
     KKYLLPFKVS IAEITGIEYD VKFIPDNPSE LEKVEEIANA HRKKAAAHTK KNDNLLMIER
     ANLNPRYTFD TFVVGKNNNF AHAASLAVAE SPGEVYNPLF LYGGVGLGKT HLMHSIAHFI
     LEKDPKKKVL YVTSEAFTNE LIESLRSGKT GNELPMTAFR EKYRNVDVLL IDDIQFIIGK
     ESTQEEFFHT FNHLHVAGKQ IIISSDKPPK DIETLEARLR TRFEWGLIAD ISAPDYETRM
     AILKKKIESD QLERYHIPED VLQFIATNIK SNIRELEGSL NKLIALYKLK NEEINISLAA
     EALKDLISPD ENRKITPELI IETVSEHFGI SVSDLKSASR DAKTTNARHI AMYLCRAMTD
     TPLKTVGSLL GGRDHSTVKH GVDKMSKDME NNDSLKNTIS IIQKKISPL
//
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