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Database: UniProt
Entry: A0A151B2W7_9CLOT
LinkDB: A0A151B2W7_9CLOT
Original site: A0A151B2W7_9CLOT 
ID   A0A151B2W7_9CLOT        Unreviewed;       451 AA.
AC   A0A151B2W7;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   25-OCT-2017, entry version 13.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA_2 {ECO:0000313|EMBL:KYH34123.1};
GN   Synonyms=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=CLTEP_19680 {ECO:0000313|EMBL:KYH34123.1};
OS   Clostridium tepidiprofundi DSM 19306.
OC   Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=1121338 {ECO:0000313|EMBL:KYH34123.1, ECO:0000313|Proteomes:UP000075531};
RN   [1] {ECO:0000313|EMBL:KYH34123.1, ECO:0000313|Proteomes:UP000075531}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 19306 {ECO:0000313|EMBL:KYH34123.1,
RC   ECO:0000313|Proteomes:UP000075531};
RA   Poehlein A., Daniel R.;
RT   "Genome sequence of Clostridium tepidiprofundi DSM 19306.";
RL   Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KYH34123.1}.
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DR   EMBL; LTBA01000025; KYH34123.1; -; Genomic_DNA.
DR   RefSeq; WP_066826142.1; NZ_LTBA01000025.1.
DR   EnsemblBacteria; KYH34123; KYH34123; CLTEP_19680.
DR   PATRIC; fig|1121338.3.peg.2029; -.
DR   Proteomes; UP000075531; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000075531};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000075531}.
FT   DOMAIN      146    274       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      358    427       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     154    161       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   451 AA;  51597 MW;  6472BD408E5421AF CRC64;
     MGIQLNEMWE KTINIVKGEL TEVSFNTWIK SITPLEIDNN ILKLSVPNNF TRDILENRYK
     GLIINAAKLI TSKQYSIEFY IQSEDEPDIK KTSKNKSKIK NSNISVSEEI TSTLNPKYTF
     NSFVIGNSNR FAHAASLAVA ESPARAYNPL FIYGGVGLGK THLMHAIGHY ILSNNPSSKV
     VYVTSEKFTN ELINSIKDDK NEDFRNKYRN VDVLLIDDIQ FIAGKERTQE EFFHTFNTLY
     EANKQIILSS DRPPKEIPTL EDRLRSRFEW GLIADIQPPD FETRIAILKK KADNENLNIS
     NEVLVYVATK IKSNIRELEG ALIRIVAYSS LTNKEISVDL ATEALKDIIS NRYSKQITVD
     LIQDIIASYY NLKVEDLKSA RRTRNIAFPR QIAMYLCRKL TDMSLPKIGE EFGGRDHTTV
     IHAYEKISQN IKKDETLKNV IAELTKKIKN E
//
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