ID   A0A151BY38_9MICO        Unreviewed;       995 AA.
AC   A0A151BY38;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Alpha-mannosidase {ECO:0000313|EMBL:KYH44673.1};
GN   ORFNames=AZH51_00140 {ECO:0000313|EMBL:KYH44673.1};
OS   Branchiibius sp. NY16-3462-2.
OC   Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Dermacoccaceae;
OC   Branchiibius.
OX   NCBI_TaxID=1807500 {ECO:0000313|EMBL:KYH44673.1, ECO:0000313|Proteomes:UP000075667};
RN   [1] {ECO:0000313|EMBL:KYH44673.1, ECO:0000313|Proteomes:UP000075667}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NY16-3462-2 {ECO:0000313|EMBL:KYH44673.1};
RA   Lapierre P., Halse T.A., Shea J., Musser K.A., Escuyer V.E.;
RT   "Draft genome assembly of Branchiibius sp. 15-3462-2 from a clinical sputum
RT   sample.";
RL   Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 38 family.
CC       {ECO:0000256|ARBA:ARBA00009792}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KYH44673.1}.
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DR   EMBL; LVCF01000034; KYH44673.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A151BY38; -.
DR   STRING; 1807500.AZH51_00140; -.
DR   Proteomes; UP000075667; Unassembled WGS sequence.
DR   GO; GO:0004559; F:alpha-mannosidase activity; IEA:InterPro.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006013; P:mannose metabolic process; IEA:InterPro.
DR   CDD; cd10789; GH38N_AMII_ER_cytosolic; 1.
DR   Gene3D; 3.20.110.10; Glycoside hydrolase 38, N terminal domain; 1.
DR   Gene3D; 1.20.1270.50; Glycoside hydrolase family 38, central domain; 1.
DR   InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR   InterPro; IPR041147; GH38_C.
DR   InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR   InterPro; IPR011682; Glyco_hydro_38_C.
DR   InterPro; IPR015341; Glyco_hydro_38_cen.
DR   InterPro; IPR037094; Glyco_hydro_38_cen_sf.
DR   InterPro; IPR000602; Glyco_hydro_38_N.
DR   InterPro; IPR027291; Glyco_hydro_38_N_sf.
DR   InterPro; IPR028995; Glyco_hydro_57/38_cen_sf.
DR   PANTHER; PTHR46017; ALPHA-MANNOSIDASE 2C1; 1.
DR   PANTHER; PTHR46017:SF1; ALPHA-MANNOSIDASE 2C1; 1.
DR   Pfam; PF09261; Alpha-mann_mid; 1.
DR   Pfam; PF17677; Glyco_hydro38C2; 1.
DR   Pfam; PF07748; Glyco_hydro_38C; 1.
DR   Pfam; PF01074; Glyco_hydro_38N; 1.
DR   SMART; SM00872; Alpha-mann_mid; 1.
DR   SUPFAM; SSF88688; Families 57/38 glycoside transferase middle domain; 1.
DR   SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR   SUPFAM; SSF88713; Glycoside hydrolase/deacetylase; 1.
PE   3: Inferred from homology;
KW   Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00023295};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000075667}.
FT   DOMAIN          518..596
FT                   /note="Glycoside hydrolase family 38 central"
FT                   /evidence="ECO:0000259|SMART:SM00872"
SQ   SEQUENCE   995 AA;  109861 MW;  1FD9CC3ED5E4FB3F CRC64;
     MHDTSALIEA RIIRFHQQRI LPAVHTHEQP MQVAAWAAPG EPVPFHEAVS REFTPLNEGD
     AWGQPWGTTW LRISGTVPSD WPGDARRELV VNLGWKPGAP GFQSEGLCYT PDGSIIKALE
     PRNSWIPIDA SSGAEFTVYV EAASNPDIGG VWGFLPTDLG DPQTAPARPL YTFGGARLTQ
     LDETMWGLER DVWTLLDVMA QLPQTSPRRA GILRALERAI DILDPQDVPA RAKDARLSLV
     DTLSRPAGAT SHRVVAVGHA HIDSAWLWPT RETKRKVART FSNVVDLMDR YPDFTFAASS
     AQQYAWLKAD YPEVFERVRA RIADGRFVPV GGMWVESDTN MPGGEAMARQ FVLGKEFFLR
     EFGVETDEVW LPDSFGYSAG LPQIVTASNS SNFLTQKISW NETDTMPHHT FLWEGIDGTQ
     VFTHFPPVDT YNSELTAVEL NRAESQHAER GLSDLSLVPF GFGDGGGGPT REMLEVALRK
     ADLEGSPQVR LGRPDEFFAS AAAELTEPAV WVGELYLEFH RGTYTSQART KFGNRRSEHL
     LREAELWAAT AAVRTEYVYP ADELRECWEI VLLQQFHDIL PGSSIAWVHQ EAERNYAAVA
     GRLGQVIDDA LHTLDTAQVA SSQIVANAAP IVQEGVTALG AAPSTPQPSR ISSDGGYTVL
     ETDYFTARVD GRGHLVSLVD HGSQREVIPP GQSGNQLLMF HDIPNQWDAW DIDKSYQQTP
     LAALDAADAP TVKGDALQVR YLTGNSTVSQ RLCASPDGRA LDIETTVDWH EQQKLLKLGF
     PIDVHTSEAA FEVQFGHIRR PTHTNTSWDS ARFEVSGHRW VRVEEPGFGV TLANDRVYGR
     DVTRHVREGG GTYSLIRESL LRAPRFPDPH ADQGEHVFRH SLRVGSLLDG VAEGYRLNLP
     LRPTAGPIEP LVRIDGSPAV IIEAVKLAQD GSGDVIVRLY EAAGGRASAR LVPTFDPGAA
     SRTDLLERPW PEQPDDALRL DLRPFELVTI RIARA
//