ID   A0A151EZ46_9EURY        Unreviewed;       423 AA.
AC   A0A151EZ46;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   RecName: Full=Radical SAM core domain-containing protein {ECO:0000259|PROSITE:PS51918};
GN   ORFNames=AYK18_04265 {ECO:0000313|EMBL:KYK33908.1};
OS   Theionarchaea archaeon DG-70.
OC   Archaea; Euryarchaeota; Theionarchaea.
OX   NCBI_TaxID=1803813 {ECO:0000313|EMBL:KYK33908.1, ECO:0000313|Proteomes:UP000075311};
RN   [1] {ECO:0000313|Proteomes:UP000075311}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Baker B.J., Lazar C.S., Teske A.P., Dick G.J.;
RL   Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|ARBA:ARBA00001966};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KYK33908.1}.
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DR   EMBL; LSSB01000137; KYK33908.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A151EZ46; -.
DR   Proteomes; UP000075311; Unassembled WGS sequence.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   CDD; cd01335; Radical_SAM; 1.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   Gene3D; 1.10.10.1150; Coenzyme PQQ synthesis protein D (PqqD); 1.
DR   InterPro; IPR023885; 4Fe4S-binding_SPASM_dom.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR000385; MoaA_NifB_PqqE_Fe-S-bd_CS.
DR   InterPro; IPR008792; PQQD.
DR   InterPro; IPR041881; PqqD_sf.
DR   InterPro; IPR007197; rSAM.
DR   PANTHER; PTHR11228:SF7; PQQA PEPTIDE CYCLASE; 1.
DR   PANTHER; PTHR11228; RADICAL SAM DOMAIN PROTEIN; 1.
DR   Pfam; PF05402; PqqD; 1.
DR   Pfam; PF04055; Radical_SAM; 1.
DR   Pfam; PF13186; SPASM; 1.
DR   SFLD; SFLDG01386; main_SPASM_domain-containing; 1.
DR   SFLD; SFLDS00029; Radical_SAM; 1.
DR   SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR   PROSITE; PS01305; MOAA_NIFB_PQQE; 1.
DR   PROSITE; PS51918; RADICAL_SAM; 1.
PE   4: Predicted;
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691}.
FT   DOMAIN          106..319
FT                   /note="Radical SAM core"
FT                   /evidence="ECO:0000259|PROSITE:PS51918"
SQ   SEQUENCE   423 AA;  48214 MW;  C9576692A19DA41D CRC64;
     MKKKYPYIVD GLYLYNNPNQ PYIFSFDQRE ALTLNHPASF ILDRCDGKTS VQDIIQKVVK
     DFAISYERAQ KDVEYTLRYA HSKGIITYTV KPLPEKRVQS VGNVNSFVPI EAFVQITYRC
     NFRCEYCFLG PPQNKDLGNV SEVFDRLFEW GTRKVVLTGG EPMVRNDFIT VLKEATQKFY
     RVDVQTNGYF IKDWEADILS LPTHVGFYIS LDGPEEYTDA LHEEGTYNRI IEGITLLQQN
     DYRIRLSILL NADNIKYYQH LKNIAEKLVG DKVSFGIALP IGKSAQKIKE MYNDQEFVFN
     YLQKMGRELL KAHNNSVFEG SSANPAVNQC GAGITTVTIT PEGDIYPCAT VCTDKRWVMG
     NIFTDQLQKI SQRISPVYAN RPEQKCEEST GYALDVFGLD FGGCFSIASE LCQKGDTFNP
     PEI
//