ID   A0A151FDE8_9EURY        Unreviewed;       342 AA.
AC   A0A151FDE8;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   RecName: Full=Radical SAM core domain-containing protein {ECO:0000259|PROSITE:PS51918};
GN   ORFNames=AYK18_00600 {ECO:0000313|EMBL:KYK38868.1};
OS   Theionarchaea archaeon DG-70.
OC   Archaea; Euryarchaeota; Theionarchaea.
OX   NCBI_TaxID=1803813 {ECO:0000313|EMBL:KYK38868.1, ECO:0000313|Proteomes:UP000075311};
RN   [1] {ECO:0000313|Proteomes:UP000075311}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Baker B.J., Lazar C.S., Teske A.P., Dick G.J.;
RL   Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|ARBA:ARBA00001966};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KYK38868.1}.
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DR   EMBL; LSSB01000003; KYK38868.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A151FDE8; -.
DR   Proteomes; UP000075311; Unassembled WGS sequence.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd01335; Radical_SAM; 1.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   InterPro; IPR023885; 4Fe4S-binding_SPASM_dom.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR017200; PqqE-like.
DR   InterPro; IPR007197; rSAM.
DR   NCBIfam; TIGR04085; rSAM_more_4Fe4S; 1.
DR   PANTHER; PTHR11228:SF7; PQQA PEPTIDE CYCLASE; 1.
DR   PANTHER; PTHR11228; RADICAL SAM DOMAIN PROTEIN; 1.
DR   Pfam; PF13353; Fer4_12; 1.
DR   Pfam; PF04055; Radical_SAM; 1.
DR   Pfam; PF13186; SPASM; 1.
DR   PIRSF; PIRSF037420; PQQ_syn_pqqE; 1.
DR   SFLD; SFLDG01386; main_SPASM_domain-containing; 1.
DR   SFLD; SFLDG01067; SPASM/twitch_domain_containing; 1.
DR   SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR   PROSITE; PS51918; RADICAL_SAM; 1.
PE   4: Predicted;
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691}.
FT   DOMAIN          1..213
FT                   /note="Radical SAM core"
FT                   /evidence="ECO:0000259|PROSITE:PS51918"
SQ   SEQUENCE   342 AA;  37726 MW;  AEE67D19833FECB1 CRC64;
     MTLKSLFVYP TFQCNLNCAH CWIRAGKKTY SELTSEEIQS TVHDALGLGL KSVKITGGEP
     FLREDITIGL LKYLDEQHIS AAVETNGTVL TPTSKKALLD YCPEVMISMD GATPQGFASL
     RGNPHLFDTV LENVRFLLDA GIELVCSMSI HKGNLGELDD FVDLVQQMDG YIRLLVYTEL
     GRAQNLEGKF TMKEITDISK RISDILKKNA KVSSNIPPAL LDGDAPFEAC AAGRESAVLL
     PNGDISFCAY TLSAHKPPAG NIGEHSLKEI WESAPMFQLL QGIESRLEKV CSACIFRNYC
     QGSCRAWAYD TYGSLTAPYP LCQKVYEEGL FPEEFLIKEV TA
//