ID A0A151LZ34_ALLMI Unreviewed; 886 AA.
AC A0A151LZ34;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=WD repeat-containing protein 91 {ECO:0000256|ARBA:ARBA00021116};
GN Name=WDR91 {ECO:0000313|EMBL:KYO17511.1};
GN ORFNames=Y1Q_0020112 {ECO:0000313|EMBL:KYO17511.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO17511.1};
RN [1] {ECO:0000313|EMBL:KYO17511.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO17511.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- SUBCELLULAR LOCATION: Early endosome membrane
CC {ECO:0000256|ARBA:ARBA00004220}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004220}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004481}. Late endosome membrane
CC {ECO:0000256|ARBA:ARBA00004414}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the WD repeat WDR91 family.
CC {ECO:0000256|ARBA:ARBA00006128}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO17511.1}.
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DR EMBL; AKHW03007000; KYO17511.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A151LZ34; -.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0141039; F:phosphatidylinositol 3-kinase inhibitor activity; IEA:InterPro.
DR GO; GO:0045022; P:early endosome to late endosome transport; IEA:InterPro.
DR GO; GO:2001033; P:negative regulation of double-strand break repair via nonhomologous end joining; IEA:InterPro.
DR GO; GO:0051898; P:negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; IEA:InterPro.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR024977; Apc4-like_WD40_dom.
DR InterPro; IPR028278; MRI.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR InterPro; IPR039724; WDR91.
DR PANTHER; PTHR13083; UNCHARACTERIZED; 1.
DR PANTHER; PTHR13083:SF3; WD REPEAT-CONTAINING PROTEIN 91; 1.
DR Pfam; PF12894; ANAPC4_WD40; 1.
DR Pfam; PF15325; MRI; 1.
DR Pfam; PF00400; WD40; 1.
DR SMART; SM00320; WD40; 4.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT REPEAT 559..600
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 563..614
FT /note="Anaphase-promoting complex subunit 4-like WD40"
FT /evidence="ECO:0000259|Pfam:PF12894"
FT REPEAT 601..642
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 259..375
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 824..871
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 185..212
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 259..294
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 311..327
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 328..344
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 826..856
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 886 AA; 98963 MW; 7A97B8F1DDD37C5E CRC64;
MAAAAERTDE LVREYLLFRG FTGALKQLDA EIKADREKGF RVDKIVDQLQ QFVQNYDLTA
LRDYWNYLDR RLFSRLEDMY RPTVNKLKTS LFRYYLVYTV QTNRNDKTQE FFVRLAAELQ
NQAEWKDWFV LPFLQAPDSN PTFAMYFSRQ WADTFIVSLH NFLSVLFQCV PVPVILNFDA
ECQRIALIQE ENEILRQKAE SYRMKKEEQQ QQEAEESIAH HKLPAYVASM DRLGDSELDM
TCSQRNIAHS LQSRGGFLSS LLSQGKKGPS KPTQTTGASP MQTGNILLGK KETSNHQSTK
GKEGATSCKE GKSNFGLTAS EANSLQQRQR RLQDHGKERK ELLSKGSSQG QSMERKLETN
ATEAEPSPEP HVEQVETVTK VSASSTEGGG IRQEQPFIVL SQDEYGEHHS SIMYCRVDCS
GRRVASLDMD GVIKVWSFNP IMQTKASSIS KSQLLSLEWA TKRDRLLLLG SGVGTVRLYD
TEAKKNLCEI TIDEEMRRIL SLACSPSGAS FVCSAAAPSL IPQLEFAGPA VGGKGVNQVP
GKLLLWDTKT MKQQLQFSLD PEPIAINCTA FNHNGNLLVT GAADGIIRLF DMQQHECAMS
WKAHDGEVHS VEFSYDENTV YSIGEDGKFI QWNIHKSGSK VSEYALPSDA TGPFVLSGYS
GYKQVQVPRG RLFAFDSEGN YMLTCSSTGG VIYKLNSDEK ILESCLSLGG HRAPVALVSA
GSCQRRRLER LLGRASVSFC TLQEMEACAS TAKKRVLPPW MIAGVAEQRE TMPPARPKRR
KKAAEAGTVT VYCMNEAELV TVALGILAEN LKCKEREDKV LSESEEEQGC QQLQIDPQWS
PASTNGSRTL KSGSKPQTEA LGCADRTVSE DEDDDVLKYV REIFFT
//
