ID A0A151M014_ALLMI Unreviewed; 1029 AA.
AC A0A151M014;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=Integrin alpha-3 {ECO:0000313|EMBL:KYO17848.1};
GN Name=ITGA3 {ECO:0000313|EMBL:KYO17848.1};
GN ORFNames=Y1Q_0011509 {ECO:0000313|EMBL:KYO17848.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO17848.1};
RN [1] {ECO:0000313|EMBL:KYO17848.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO17848.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO17848.1}.
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DR EMBL; AKHW03006853; KYO17848.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A151M014; -.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR018184; Integrin_alpha_C_CS.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF9; INTEGRIN ALPHA-6; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF20806; Integrin_A_Ig_3; 1.
DR Pfam; PF00357; Integrin_alpha; 1.
DR PRINTS; PR01185; INTEGRINA.
DR SMART; SM00191; Int_alpha; 4.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR PROSITE; PS51470; FG_GAP; 3.
DR PROSITE; PS00242; INTEGRIN_ALPHA; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT TRANSMEM 971..993
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 254..315
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 316..371
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 373..434
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 419..576
FT /note="Integrin alpha first immunoglubulin-like"
FT /evidence="ECO:0000259|Pfam:PF08441"
FT DOMAIN 582..747
FT /note="Integrin alpha second immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20805"
FT DOMAIN 753..959
FT /note="Integrin alpha third immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20806"
SQ SEQUENCE 1029 AA; 115030 MW; B351A37CAD17E2A8 CRC64;
MHWQLQPQDK RLLLVGAPRE KAFPAQQANR TGGLYWCDII SETYCTRVMF DEKTDPEKES
KEDQWMGVTV RSQGPGGKVV TCAHRYEKRQ YVNTLQETRD IIGRCYVLSQ NLTIVDDMDG
GEWSFCDGRL RGHEKFGSCQ QGVAATFTRD YHYIVFGAPG TYNWKGVVRA EQKNQTFYEL
SIFDDGPYEV GDEASRDESL VPVPANSYLG FSLDSGKGIV SQEEITFVSG APRANHSGAV
VLLRKDPSIQ SALSLVHIFE GEGLASSFGY DVAVVDLNKD GWQDIVVGAP QYFERDEDIG
GAVYIYINQN GNWEGVKPVR LNGTTDSMFG LAVESIGDVN QDGFPDIAVG APYDGSGKVY
IYHGSKNGIN TKATQILDGE ENNIQFFGYS IAGNMDLDRN SYPDIAVGSL SDSVSVYRSR
PVISIKKTIK ILPDKIDLNR RTCPEPSGIC LNVEACFEYT ASPQDFNPKI KLNYTFEAEK
DRRRLGLPSR VHFPNHPSDQ LTGSIKLQGQ NTRECVKTSL VLQENIKDKL RPIPLSVDVK
ISGSDSGSQS RRRQGRALPD LVPVLNSNEP ETVKAEFLKE GCGEDNICNS NLKLQYRFCT
REGNEDRFSY LPIENSVPVL VLKDQKDIAL EITVTNNPSD AKNPKKDGED AHEAKLIATF
PDSLTYSTFR ELRAYPEKQL TCGANQNGSQ AECELGNPFK RNSNVTFYLV LSTTKVNVDT
TDLDITLELE TTSNQVNLVP ITATAKVVIQ LLLSVTGVAK PSQVYFGGNI IGESAMKSED
DIGNLIEYEF RITNLGRPLK TFGTASLDIQ WPKEIDNGKW LLYLMKVESK ELGIIPCEPR
NEINYLQLRD SHNSRRKREI AEKQINDGKK FSLFSERKYK TLDCRGSARC VNIKCPLQGL
DSKALVVLRS RLWNSTFLEE YSKLNYLDIV VRATISIPAA AENVKLTNET AQVRVTVFPA
KTVAHYTGVP WWIILVAILA GILMLALLVF LLWKCGFFKR NKKDHYDATY HKAEIHAQPS
DKERLTSDA
//
