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Database: UniProt
Entry: A0A151M057_ALLMI
LinkDB: A0A151M057_ALLMI
Original site: A0A151M057_ALLMI 
ID   A0A151M057_ALLMI        Unreviewed;      1910 AA.
AC   A0A151M057;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   10-MAY-2017, entry version 8.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   ORFNames=Y1Q_0011553 {ECO:0000313|EMBL:KYO17907.1};
OS   Alligator mississippiensis (American alligator).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC   Alligator.
OX   NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO17907.1};
RN   [1] {ECO:0000313|EMBL:KYO17907.1, ECO:0000313|Proteomes:UP000050525}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO17907.1};
RX   PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA   St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y.,
RA   Gongora J., Dalzell P., Moran C., Bed'hom B., Abzhanov A.,
RA   Burgess S.C., Cooksey A.M., Castoe T.A., Crawford N.G., Densmore L.D.,
RA   Drew J.C., Edwards S.V., Faircloth B.C., Fujita M.K., Greenwold M.J.,
RA   Hoffmann F.G., Howard J.M., Iguchi T., Janes D.E., Khan S.Y.,
RA   Kohno S., de Koning A.J., Lance S.L., McCarthy F.M., McCormack J.E.,
RA   Merchant M.E., Peterson D.G., Pollock D.D., Pourmand N., Raney B.J.,
RA   Roessler K.A., Sanford J.R., Sawyer R.H., Schmidt C.J., Triplett E.W.,
RA   Tuberville T.D., Venegas-Anaya M., Howard J.T., Jarvis E.D.,
RA   Guillette L.J.Jr., Glenn T.C., Green R.E., Ray D.A.;
RT   "Sequencing three crocodilian genomes to illuminate the evolution of
RT   archosaurs and amniotes.";
RL   Genome Biol. 13:415-415(2012).
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KYO17907.1}.
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DR   EMBL; AKHW03006853; KYO17907.1; -; Genomic_DNA.
DR   Proteomes; UP000050525; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR008051; Na_channel_a1su.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 5.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PRINTS; PR01664; NACHANNEL1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000050525};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM     27     46       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM     53     76       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    124    144       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    179    200       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    206    226       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    356    383       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    659    683       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    695    716       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    778    806       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    865    891       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1120   1138       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1159   1178       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1190   1213       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1234   1262       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1360   1384       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1443   1461       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1473   1491       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1498   1523       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1560   1588       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1664   1687       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN       56    162       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      165    390       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      416    617       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      668    895       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      905   1114       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1118   1392       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1442   1697       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1701   1762       GPHH. {ECO:0000259|Pfam:PF16905}.
FT   COILED      380    425       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1910 AA;  218210 MW;  D7BEACAD11F8BBC0 CRC64;
     MVSEPLEDLD PYYINKKTFI VLNKGKAIFR FSATSALYIL TPFNPLRKIA IKILVHSLFS
     MLIMCTILTN CVFMTMSNPP DWTKNVEYTF TGIYTFESLI KIIARGFCLE AFTFLRDPWN
     WLDFTVITFA YITEFVNLGN VSALRTFRVL RALKTISVIP EFVDLGNVSA LRTFRVLRAL
     KTISVIPGLK TIVGALIQSV KKLSDVMILT VFCLSVFALI GLQLFMGNLR NKCLQWPPEN
     FTLETNITSL LNSTIGENDT LVNTTVTEFD WKGYIDDERH FYFLEGQNDA LLCGNSSDAG
     QCPEGYVCVK AGRNPNYGYT SFDTFSWAFL SLFRLMTQDF WENLYQLTLR AAGKTYMIFF
     VLVIFLGSFY LINLILAVVA MAYDEQNQAT QEEAEQKEAE FQQMLEQLKK QQEAVQKEQS
     GGEEKDEDEF HKSESEDSIR RKGFRFSIEG NRLTYEKKYS SPHQSLLSIR GSLFSPRRNS
     RTSLFSFRGR AKDIGSENDF ADDEHSTFED NDSRRDSLFV PRRPGERRNS NISQASRSSR
     MLAVFPMNGK MHSTVDCNGV VSLVGGPSVP TSPVGQLLPE GTTTETEMKK RRSNSFNVSM
     DFLEDPALRE RAMSIASILT NTMEELEESR QKCPPCWYKF ANIFLIWDCS PYWLKVKRIV
     NLIVMDPFVD LAITICIVLN TLFMAMEHYP MTPEFNHVLS VGNLVFTGIF TAEMFLKIVA
     MDPYYYFQEG WNIFDGFIVT LSLIELGLAN VEGLSVLRSF RLLRVFKLAK SWPTLNMLIK
     IIGNSVGALG NLTLVLAIIV FIFAVVGMQL FGKNYKECVC KIASDCVLPR WHMQDFFHSF
     LIVFRVLCGE WIETMWDCME VAGQAMCLTV FMMVMVIGNL VVLNLFLALL LSSFSADNLA
     ATDDDNEMNN LQIAVARMQK GVDYVKRKVH EFIQKSFVKK QKALEEIKPL EDLNNKKNSC
     ISNHMTAEIS KDHDYLRDGN GTTSGIGTGS SVEKYIIDES DYMSFINNPS LTVTVPIAVG
     ESDFENLNTE EFSSEDQSDL EESKEKLNLS SSSEGSTVDI GLPAEEQPEI EPEEAMEPEA
     CFTEDCVRRF KCCQVSVEDG RGKQWWSLRK TCFRIVEHNW FETFIVFMIL LSSGALAFED
     IYIEQRKTIK TMLEYADKVF TYIFILEMLL KWVAYGYQTY FTNAWCWLDF LIVDVSLVSL
     TANALGYSEL GAIKSLRTLR ALRPLRALSR FEGMRVVVNA LLGAIPSIMN VLLVCLIFWL
     IFSIMGVNLF AGKFYYCVNT TTDERFEVEV INNYSQCREL IDANQSARWK NVKVNFDNVG
     FGYLSLLQVA TFKGWMDIMY AAVDSRNVLD QPKYEDNLYM YLYFVIFIIF GSFFTLNLFI
     GVIIDNFNQQ KKKFGGQDIF MTEEQKKYYN AMKKLGSKKP QKPIPRPGNK FQGMVFDFVT
     QQVFDITIMI LICLNMVTMM VETDDQSKEM ENILQRINLV FIVLFTGECV LKMISLRYYY
     FTIGWNIFDF VVVILSIVGM FLSELIEKYF VSPTLFRVIR LARIGRILRL IKGAKGIRTL
     LFALMMSLPA LFNIGLLLFL VMFIYAIFGM SNFAYVKREA GIDDMFNFET FGNSMICLFQ
     ITTSAGWDGL LAPILNSGEP DCDPYRVHPG SSVKGDCGNP SVGIFFFVSY IIISFLVVVN
     MYIAVILENF GVATEESAEP LSEDDFEMFY EVWEKFDPDA TQFMEFEKLS EFAAALEPPL
     HLPKPNKVQL IAMDMPMVSG DRIHCLDILF AFTKRVLGES GEMDALRIQM EDRFMAANPS
     KASYEPITTT LKRKQEEVSA SIIQRAFRRH LLKQTVKQAS FIYNKNKNEG GAGLCIKDEI
     LIDKLNENSF TEKTDMTTST AICPPSYDRV TRPVKEKYEH EDKDVQEKEK
//
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