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Database: UniProt
Entry: A0A151M092_ALLMI
LinkDB: A0A151M092_ALLMI
Original site: A0A151M092_ALLMI 
ID   A0A151M092_ALLMI        Unreviewed;      1839 AA.
AC   A0A151M092;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   10-MAY-2017, entry version 7.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   ORFNames=Y1Q_0011551 {ECO:0000313|EMBL:KYO17902.1};
OS   Alligator mississippiensis (American alligator).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC   Alligator.
OX   NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO17902.1};
RN   [1] {ECO:0000313|EMBL:KYO17902.1, ECO:0000313|Proteomes:UP000050525}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO17902.1};
RX   PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA   St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y.,
RA   Gongora J., Dalzell P., Moran C., Bed'hom B., Abzhanov A.,
RA   Burgess S.C., Cooksey A.M., Castoe T.A., Crawford N.G., Densmore L.D.,
RA   Drew J.C., Edwards S.V., Faircloth B.C., Fujita M.K., Greenwold M.J.,
RA   Hoffmann F.G., Howard J.M., Iguchi T., Janes D.E., Khan S.Y.,
RA   Kohno S., de Koning A.J., Lance S.L., McCarthy F.M., McCormack J.E.,
RA   Merchant M.E., Peterson D.G., Pollock D.D., Pourmand N., Raney B.J.,
RA   Roessler K.A., Sanford J.R., Sawyer R.H., Schmidt C.J., Triplett E.W.,
RA   Tuberville T.D., Venegas-Anaya M., Howard J.T., Jarvis E.D.,
RA   Guillette L.J.Jr., Glenn T.C., Green R.E., Ray D.A.;
RT   "Sequencing three crocodilian genomes to illuminate the evolution of
RT   archosaurs and amniotes.";
RL   Genome Biol. 13:415-415(2012).
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KYO17902.1}.
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DR   EMBL; AKHW03006853; KYO17902.1; -; Genomic_DNA.
DR   Proteomes; UP000050525; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000050525};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    124    147       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    223    244       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    250    270       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    388    415       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    760    778       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    790    813       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    825    849       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    870    898       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    928    945       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    957    983       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1199   1217       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1238   1260       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1266   1286       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1315   1341       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1437   1463       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1522   1540       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1552   1570       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1582   1602       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1639   1667       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1743   1766       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      127    422       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      495    709       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      760    988       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      997   1193       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1197   1472       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1521   1776       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      412    453       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1839 AA;  209259 MW;  B2710EE7CAC8264A CRC64;
     MAQAMLGPPG PDSFFYFTRE SLAAIEKRIA EEKAKGDSKD EGGDEGNGCK PNKDLEAGKT
     LPFIYGDIPP GMVSTPLEDI DPYYINKKTF IVLNKGKTIF RFSATPALYI LSPFSSLRKL
     AIKILVHSLF SIFIMCTILT NCGFMTMNKT PEWAKNVEYT FTGIYTFESL VKIIARGFCI
     DHFTFLRDPW NWLDFTVITF AYLTEFVDLG NVSALRTFRV LRALKTISVI PGLKTIVGAL
     IQSVKKLSDV MILTVFCLSV FALIGLQLFM GHLKHKCLLW PKENTSAFDK YVAPYFNDTV
     FMWEEYLENE SHFYYLEGQK DALLCGNGTD AGQCPEDYIC VKAGRNPNYG YTSFDTFSWA
     FLSLFRLMTQ DYWENLYQLT LRAAGKTYMI FFVLVIFLGS FYLINLILAV VAMAYDEQNQ
     ATQEEAEQKE AEFQQMLEQL KKQQEEAQAI AAAAFEITDF SGEGRIGRLS ESSSEASKLS
     SKSAKERRNR RKKRRQRELS AGEDQVKDGK LPKSESDGSI RRKGFHFSLD GNKLTYEKRL
     TSPHQSLLSI RGSIFSPRRN SRTSLFSFRG QGKDIGSEND FADDEHSTFE DNGSRRGSLF
     VPCRHGERRN SNISQASRSS RRLPMLSVNG KMHCTVDCNG VVSLADRQPS LLSPTGQLLP
     EVIIDKPTTD DNSTTTEIEI RKRRSSSYQV SMDLLEDPTI RQRAMSIASI LTNTMEELEE
     SRQKCPPCWY KFANTFLIWD CWEPWLNVKR IVNVIVMDPF VDLAITICII LNTLFMAMEH
     YPMTVQFHDV LVVGNLVFTG IFTAEMVLKI IAMDPYYYFQ VGWNIFDGII VTLSLVELFL
     SNVDGLSVLR SFRLLRVFKL AKSWPTLNML IKIIGNSVGA LGNLTLVLAI IVFIFAVVGM
     QLFGKSYMEC VCKISKDCVL PRWHMYDFYH SFLIVFRVLC GEWIETMWDC MEVAGQAMCL
     IVFMMVMVIG NLVVLNLFLA LLLSSFSSDN LAAPDDDNEM NNLQIAMTRI QKGIDYVKRE
     VYECIQKTLF RKQKAPDEVR SIDQLTDRKD GCISNHTVAE IKKDLRYRKN ENGTTSVVLG
     SDYASFINNP SLTVTVPIAV GESDFDQLNT EEFSSESELE EGKEKLNISS SSEGSTIDLV
     PAGEEKAEAE PEQTSEPKAC FTEGCVRRFK CCQINVESGK TKVWWNFRRT CYRIVEHSWF
     ESFIVFMILL SSGALAFEDI YIEQRKTIKT ILEYADKVFT YIFILEMVLK WVAYGFQVYF
     TNAWCWLDFL IVDVSLISLT ANALGYSELG PIKSLRTLRA LRPLRALSRF EGMRVVVNAL
     VGAIPSIMNV LLVCLIFWLI FSIMGVNLFA GKFFSCVNLT NGERFLADKV KNKNACEYLM
     ENDDNVRWKN VKVNFDNVGA GYLSLLQVAT FKGWTDIMYA AVDSVDINMQ PSYEISWFMY
     IYFVIFIIFG SFFTLNLFIG VIIDNFNQQK KKLGGQDIFM TEEQKKYYNA MKKLGSKKPQ
     KPIPRPANKF QGLVFDLVTK QAFDITIMIL ICLNMVTMMV ETDEQSKQVT DVLDQINVVF
     IVLFTGECVL KLFSLRYYYF KIGWNIFDFV VVILSIIGMY LTDLIEEYFV SPTLFRVIRL
     ARIGRILRLI KGAKGIRTLL FALMMSLPAL FNIGLLLFLV MFIYAIFGMS NFAYVKREAG
     IDDMFNFETF CNSMICLFQI TTSAGWDGLL APILNSGEPD CDPYRVHPGS SVKGDCGNPS
     VGIFFFVSYI IISFLVVVNM YIAVILENFS VATEESAEPL SEDDFEMFYE VWEKFDPDAT
     QFIEFSKLSD FASSLDPPLH LPKPNIIQLI AMDLPMSGP
//
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