ID A0A151M0V3_ALLMI Unreviewed; 1720 AA.
AC A0A151M0V3;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Lactase-phlorizin hydrolase {ECO:0000313|EMBL:KYO18086.1};
GN Name=LCT {ECO:0000313|EMBL:KYO18086.1};
GN ORFNames=Y1Q_0011679 {ECO:0000313|EMBL:KYO18086.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO18086.1};
RN [1] {ECO:0000313|EMBL:KYO18086.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO18086.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO18086.1}.
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DR EMBL; AKHW03006853; KYO18086.1; -; Genomic_DNA.
DR STRING; 8496.A0A151M0V3; -.
DR eggNOG; KOG0626; Eukaryota.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR Gene3D; 3.20.20.80; Glycosidases; 4.
DR InterPro; IPR001360; Glyco_hydro_1.
DR InterPro; IPR018120; Glyco_hydro_1_AS.
DR InterPro; IPR033132; Glyco_hydro_1_N_CS.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR PANTHER; PTHR10353; GLYCOSYL HYDROLASE; 1.
DR PANTHER; PTHR10353:SF38; LACTASE_PHLORIZIN HYDROLASE; 1.
DR Pfam; PF00232; Glyco_hydro_1; 3.
DR PRINTS; PR00131; GLHYDRLASE1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 4.
DR PROSITE; PS00572; GLYCOSYL_HYDROL_F1_1; 2.
DR PROSITE; PS00653; GLYCOSYL_HYDROL_F1_2; 3.
PE 4: Predicted;
KW Glycosidase {ECO:0000256|RuleBase:RU004468};
KW Hydrolase {ECO:0000256|RuleBase:RU004468, ECO:0000313|EMBL:KYO18086.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525}.
FT REGION 1697..1720
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 1123
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10055"
FT ACT_SITE 1600
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10055"
SQ SEQUENCE 1720 AA; 195910 MW; 31DE3A4C7AFC29D1 CRC64;
MVKTSTFVDL FVEYAEFNFR SFGDLVDMWL TFSHLPEVLQ SLPYDDPSSS LQALVAAHER
TYTLYHEKYS TGGKLSIALE INHHFETIPL ESLSASLRDS VDFLSLSLHY DCRNEENLQK
NLKSFQNIWK NMAVLLFSLT FHECNSKTEN MPIPVAALFK DIIKEEALTM GYDVNKFLDS
SSARAFSSYA GNALQEGQAA APLSSYQKVW ETFANQTALE RDSFLSDVFP SGFLWGVSTG
AFNIEGGWAE DGKGESIWDQ FGHQGHAYMN QTADVACDSY HKTNYDVYLL RGLQSKLYKF
SISWSRIFPS GIKASLNPRG VDYYNKLINS LQDSNIEPMI TLFHWDLPQA LQDLGGWQND
SIVDAFAAYA DFCFATFGDR VKLWITFHEP WVISYAGYGT GKHPPGIVNP GVASYKVAHT
ILKAHAKAWR LYDDKYRSQQ HGKVGLVLNS DWAEPRSPAS LDDVKAAERY MHFMLGWFAH
PIFVNGDYPD ILKSQIQQTN QHCSSPVAHL PSFTEEEKLL VKGTADFFGL SHYTSQLVSA
GANDTCSPAY ENFGNFSQHV DPAWPQTVSS WIRVVPWGLR RLLNFVSQEY TGTKVPIYIA
GSGMPTGAGG DAVNDTERMD YFRLYINEAL KAVKLDAVDV QSYIVRSLID GFEGPVGYSQ
RFGLHHVEFG DSNRQRTPKK SAYYFSNIIE KNGFPSKVLH RSFKPVTFDT ALPMRLLGLP
ASEVPSKAKV VWEKFSPQTK FERDMYFYGN FPGDFVWGVS TSAYQIEGGW DADGKGPSIW
DNFTHIPGNI KNSDTGDIAC DSYHKVDEDL YMLRALGVKS YRFSLSWPRI FPTGRNDSIN
SHGVDYYNRL IDGLTANNIT PMVTLYHWDL PQALQDIGGW ENESLIDLFN SFADFCFQTF
GDRVKFWMTL NEPYVSAWIA YGVGEFPPNV KNDPGYAPYK IAHTLLKAHA RVYHTYDRKY
RASQRGVISL SLNADWVEPK TLDDPRDTEA ADRSLQFMLG WFAHPIFKNG DYPEAMKWTV
GNRSELQNLP LSRLPAFTAQ ERGYIRGTAD VFCINTYTSS IVKHKTPKLK PFSYEDDQEL
SSEVDSSWPT SALANMRPVA WGLRRLLNWI KEEYNNPPIY ITENGVGIKA TPDVDDTNRI
FYYKTYIDEA LKASRLDGVN LRGYIAWSLM DSFEWVNGYD PRFGLHQVDF KNPSRPRTPK
RSALYYAEVI RNNGIPLPKE DEFVYGEFPK NFSWSVASAA YQIEGAWRED GKGLSIWDQF
AHTPLKISND ETADIACDSY HKIEEDLASL KGLKVTHYRF SISWSRVLPD GTTKLINEVG
LNYYERLIDA LLAADIKPQV TIYHWDLPQA LQNIGGWENE TIVQRFKEYA EVLFQRLGDK
VKFWITLNEP YIIANLGYGY GTSAPGISFR PGRAPYIVGH NLLKAHAEVW HLYNTTYRPK
QRGLISITIN SDWAEPRNPD KQEDIDAARR YVQFYGGWFA HPIFKNGDYN EVMKRRIRER
SLAQGLNESR LPEFTESEKQ RIKGTFDYFG FNHYTTILAS NLNYAAGISS YDSDRGVASI
TDRSWLGSGS FWLKVTPFGF RKILRWIKEE YNNPPIYVTE NGISERGYTG LNDTWRMHYY
KSYINEALKA VVLDGVDLRG YTAWSLMDNF EWATGFAERF GLYYTNYTDP ALPRIPKESA
SYYSSIIQCN GFPDPATGPH PCLQPQPEGD YPKESTNHHT
//
