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Database: UniProt
Entry: A0A151M2W1_ALLMI
LinkDB: A0A151M2W1_ALLMI
Original site: A0A151M2W1_ALLMI 
ID   A0A151M2W1_ALLMI        Unreviewed;      4987 AA.
AC   A0A151M2W1;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   25-OCT-2017, entry version 9.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:KYO18849.1};
GN   ORFNames=Y1Q_0009256 {ECO:0000313|EMBL:KYO18849.1};
OS   Alligator mississippiensis (American alligator).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC   Alligator.
OX   NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO18849.1};
RN   [1] {ECO:0000313|EMBL:KYO18849.1, ECO:0000313|Proteomes:UP000050525}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO18849.1};
RX   PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA   St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y.,
RA   Gongora J., Dalzell P., Moran C., Bed'hom B., Abzhanov A.,
RA   Burgess S.C., Cooksey A.M., Castoe T.A., Crawford N.G., Densmore L.D.,
RA   Drew J.C., Edwards S.V., Faircloth B.C., Fujita M.K., Greenwold M.J.,
RA   Hoffmann F.G., Howard J.M., Iguchi T., Janes D.E., Khan S.Y.,
RA   Kohno S., de Koning A.J., Lance S.L., McCarthy F.M., McCormack J.E.,
RA   Merchant M.E., Peterson D.G., Pollock D.D., Pourmand N., Raney B.J.,
RA   Roessler K.A., Sanford J.R., Sawyer R.H., Schmidt C.J., Triplett E.W.,
RA   Tuberville T.D., Venegas-Anaya M., Howard J.T., Jarvis E.D.,
RA   Guillette L.J.Jr., Glenn T.C., Green R.E., Ray D.A.;
RT   "Sequencing three crocodilian genomes to illuminate the evolution of
RT   archosaurs and amniotes.";
RL   Genome Biol. 13:415-415(2012).
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KYO18849.1}.
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DR   EMBL; AKHW03006780; KYO18849.1; -; Genomic_DNA.
DR   Proteomes; UP000050525; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000050525};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4298   4316       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4520   4540       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4594   4613       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4730   4751       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4788   4809       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4864   4887       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      151    206       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      213    258       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      266    321       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      327    384       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      392    449       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      652    850       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1066   1263       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1397   1602       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     4041   4076       EF-hand. {ECO:0000259|PROSITE:PS50222}.
SQ   SEQUENCE   4987 AA;  567180 MW;  B35EBF5FD8CA907D CRC64;
     MAARLHADQG SARDSGSRWI PPPCLVFPVF LLGQEQLRLD PIWHVEQAWL GPDQVVQWEA
     NLDDEVVLQC TATVHKEQQK LCLAAEGFGN RLCFLESTSN SKNVPPDLSI CTFVLEQSLS
     VRALQEMLAN TEEKAEGLVD VEKWTAQGGG HRTLLYGHAI LLRHSYSGMY LCCLSTSRSS
     MDKLAFDVGL QEDTTGEACW WTIHPASKQR SEGEKVRVGD DLILVSISSE RYLHLSYGNG
     SLHVDAAFQQ TLWSVAPISS GSEVAQGYLI GGDVLRLLHG HMDECLTVPS GEHGEELRRT
     VHYEGGAVSI HARSLWRLET LRVAWSGSHI RWGQPFRLRH ITTGKYLSLL DDKSLLLTDK
     EQADVKSTAF CFRSSKEKLD VGIRKEVDGM GAPEIKYGDS VCYIQHIDTG LWLTYQSVDA
     KSVRMGSVQR KAIMHHEGHM DDGLTLSRSQ HEESRTARVI RSTVFLFNRF IRGLDALSKK
     AKSSTVDLPI ESVSLSLQDL IGYFHPPDEH LEHEDKQNRL RALKNRQNLF QEEGMINLVL
     ECIDRLHVYS SAAHFADVAG KEAGETWKSI LNSLYELLAA LIRGNRKNCA QFSGSLDWLI
     SRLERLEASS GILEVLHCVL VESPEALNII KEGHIKSIIC LLDKHGRNHK VLDVLCSLCV
     CHGVAVRSNQ HLICDNLLPG RDLLLQTRLV NHVSSMRPNI FLGISEGSAQ YRKWYYELMV
     DHVEPFVTAE ATHLRVGWAS TEGYSPYPGG GAEWGGNGVG DDLYSYGFDG LHLWSGCVAR
     TVNSPNQHLL KTDDVVSCCL DLSAPSISFR INGQPVQGMF ENFNIDGLFF PVVSFSAGIK
     VRFLLGGRHG EFKFLPPPGY APCFEAVLPK EKLKVEQSRE YKQDRNGTKD LLGPTISLSQ
     AAFTPIPVDT SQIVLPPHLE RIREKLAENI HELWVMNKIE LGWQYGPVRD DNKRQHPCLV
     EFSKLPEQER NYNLQMSLET LKTLLALGCH VGITDEHAEE KVKKVKLPKN YQLSSGYKPT
     PMDLSSIKLT PSQEAMVDKL AENAHNVWAR DRIRQGWTYG IQQDVKNRRN PRLVPYALLD
     DRTKKSNKDS LREAVRTLLG YGYNLEAPDQ DHATRSDVYS GIMEKFRIFR TEKTYAVKSG
     KWYFEFEAVT AGDMRVGWTR PGCLPDQELG ADEQAFVFDG FKAQRWHQGN EHFGRSWLAG
     DVVGCMVDMN EHTMMFTLNG EILLDDSGSE LAFKDFEVGD GFIPVCSLGS SQVGRMNFGK
     DVSTLKYFTI CGLQEGYEPF AVNTNRDITM WLSKRLPQFL PVPPNHEHIE VMRIDGTIDS
     CPCLKVTKKS FGSNSKTDVM FFRLSMPIEC AEVFSKTPAG GLPGSGLFGP KNDLEDYDAD
     SDFEVLMKTA HGHLVPDRVE REKEAAKPEF NNHKDYTQEK PSRLKQRFML RRTKPDYSTS
     HSARLTEDVL ADDRDDYDYL MQTSTYYYSV RIFPGQEPAN VWVGWITSDF HQYDTTFDLD
     RVRTVTVTLG DEKGKVHESI KRSNCYMVCA GESMSPGQGR NNNGLEIGCL VDAASGLVTF
     TANGKELSTY YQVEPSTKLF PAVFAQATSP NVFQFELGRI KNVMPLSAGL FKSEHKNPVP
     QCPPRLHVQF LTHVLWSRVP NHFLKVDVSR VSERQGWMIQ CLDPLQFMAL HVPEENRSID
     ILELTEQEEL LKFHYHALRL YSAVCALGNN RVAHAMCSHV DESQLLYAIE NKYMPGLLRT
     GYYDLLIDIH LNTYATARLM MNNEFIVPMT DETKSITLFP DENKKHGLPG IGLSTSLRPR
     MQFSSPSFVS ISSECYQFSP EFPLEILKAK TIEMLTEAVQ EGSLHVRDPV GGSTEFLFVP
     LIKLFYTLLI MGVFHNGDLK HILQLIEPRV FKEDTSQEDE NEMPEKELTT KELKPEGGEE
     EARGEQVPKE GLLQMKLPEP VKLQMCHLLQ YLCDCQIRHR IEAIVAFSDD FVAKLQENQR
     FRYNEVMQAL NMSAALTARK TKEFRSPPQE QINMLLNFKD DKSDCPCPEE IRDQLLDFHE
     DLMTHCGIEL DEDGALDGSS DLTIRGRLLY LVEKMTYLKK KQTEKPTDNH SKKPSTLQQL
     ISDTMVRWAQ ESVIEDPELV RAMFVLLHRQ YDGIGGLVRT LPKTYTINSV SVEDTINLLA
     SLGQIRSLLS VRMGKEEEKL MIRGLGDIMN NKVFYQHPNL MRALGMHETV MEVMVNVLGG
     GESKEITFPK MVANCCRFLC YFCRISRQNQ KAMFDHLSYL LENSSVGLAS PSMRGSTPLD
     VAAASVMDNN ELALALREPD LEKVVRYLAG CGLQSCPLLI SKGYPDIGWN PVEGERYLDF
     LRFAVFCNGE SVEENANVVV RLLIRRPECF GPALRGEGGN GLLAAMEEAI KISEDPTRDG
     PSPSNGSCKT LEMEEQEDDT IHVGNAIMTF YAALIDLLGR CAPEMHLIHA GKGEAIRIRS
     ILRSLIPLED LVGVISIPFH MPTIAKDGTV VEPDMSAGFC PDHKAAMVLF LDRVYGIEDQ
     DFLLHLLEVG FLPDLRAAAS LDTAALSATD MALALNRYLC TAVLPLLTRC APLFAGTEHH
     ASLIDSLLHT VYRLSKGCSL TKAQRDSIEE CLLSICGQLR PSMMQHLLRR LVFDVPLLNE
     HAKMPLKLLT NHYERCWKYY CLPGGWGNFG AASEEELHLS RKLFWGIFDA LSQKKYEQEL
     FKLALPCLSA VAGALPPDYM ESNYVSMMEK QSSMDSDGNF NPQPVDTSNS TIPEKLEYFI
     NKYAEHSHDK WSMEKFANGW IYGEMYSESA KVQPLMKQYK LLSEKEKEIY RWPIKESLKT
     MLAWGWRIER TREGDTMALY NRTRRISQTS QVSVDTAHGY SPRAIDMSNV TLSRDLHAMA
     EMMAENYHNI WAKKKKMELE AKVGGGNHPL LVPYDTLTAK EKAKDREKAQ DILKFLQING
     YIVSRGLKDL ELDTPSIEKR FAYSFLQQLI RYVDEAHQYI LEFDGGSRGK GEHFPYEQEI
     KFFAKVVLPL IDQYFKNHRL YFLSAASRPL STGGHASNKE KEMVTSLFCK LGVLVRHRIS
     LFGNDATSIV NCLHILGQTL DARTVMKTGL ESVKMALRAF LDNAAEDLEK TMENLKQGQF
     THTRNQPKGV TQIINYTTVA LLPVLSSLFE HIGQHQFGED LILEDVQVSC YRILASLYAL
     GTSKSIYVER QRSALGECLA AFAGAFPVAF LETHLNKHNM YSIYNTKCAR DRAALDLPTS
     VDEVCPNIPS LEKLMEEIVE LAESGIRYTQ MPHIMEVILP MLCSYMSHWW EHGPENNPEK
     AEMCCTGLTS EHMNTLLGNI LKIIYNNLGI DEGAWMKRLA VFSQPIISKA KPQLLKTHFL
     PLMDKLKKKA AMVISDEEHL RAEGRGDMSE AELLILDEFT TLARDLYAFY PLLIRFVDYN
     RAKWLKEPNP EAEELFRMVA DVFIYWSKSH NFKREEQNFV VQNEINNMSF LITDTKSKMS
     KAAVSDQERK KMKRKGDRYS TQTSLIVAAL KRLLPIGLNI CAPGDQELIA LAKTRFSMKD
     TEDEVRDIIR SNLHLQGKLE DPAIRWQMAL YKDLPNRTEN TSDPEKTVER VLDIANVLFH
     LEQVEHPQRS KKAVWHKLLS KQRKRAVVAC FRMAPLYNLP RHRAVNLFLQ GYEKSWIETE
     EHYFEDKLIE DLARPGEEPP EEEESIKRVD PLHQLILLFS RTALTEKCKL EEDFLYMAYA
     DIMAKVTGSQ RSKEKEMEKQ KLLYQQARLH DRGAAEMVLQ TISASKGEMG PMVAATLKLG
     IAILNGGNST VQQKMLDYLK DKKDVGFFQS LAGLMQFCSV LDLNAFERQN KAEGLGMVTE
     EGSGEKVMQD DEFTCDLFRF LQLLCEGHNS DFQNYLRTQT GNNTTVNIII STVDYLLRVQ
     ESISDFYWYY SGKDVIDEQG QRNFSKAIQV AKQVFNTLTE YIQGPCTGNQ QSLAHSRLWD
     AVVGFLHVFA HMQMKLSQDS SQIELLKELM DLQKDMVVML LSMLEGNVVN GTIGKQMVDM
     LVESSNNVEM ILKFFDMFLK LKDLTSSDAF KEYDPDGKGV ISKRDFQKAM ESHKHYTQSE
     TEFLLSCAEP DENETLDYEE FVKRFHEPAK DIGFNVAVLL TNLSEHMPHD TRLQTFLELA
     ESVLNYFQPF LGRIEIMGSA KRIERVYFEI SESSRTQWEK PQVKESKRQF IFDVVNEGGE
     KEKMELFVNF CEDTIFEMQL AAQISESDLS ERSANKEESE KDKLEEQDPR MGFFSLVTVK
     SALVALKYNI MTLMKMLSVK SLKKQMKKMK KMTMKDMVTA FFSSYWSILM GLLHFTSSVF
     RGFFRIMYSL LLGGSLVEGA KKIKVAELLA NMPDPTQDEV RGEGEEGERK PTETALPAED
     LTDLTALSDD GDLLSDIFGL DLKREGGQYK LIPHNPNAGL SDLLSTPSLL PLPEVQEKVQ
     EQKVKEDEKD EKEESKSEPE KAEGEDGEKE EKTKDEKGKQ KLRQLHTHRY GEPEVQESAF
     WKKIIAYQQK LLNYFARNFY NMRMLALFVA FAINFILLFY KVSTSSVTEE KEVHVVHAGE
     NSKLNSLESG SHRIITVHYV LEESSGYMEP TLRILAILHT VISFFCIIGY YCLKVPLVIF
     KREKEVARKL EFDGLYITEQ PSEDDIKGQW DRLVINTQSF PNNYWDKFVK RKVMDKYGEF
     YGRDRISELL GMDKAALDFS DAREKKKPKK DSSLSAVLNS IDVKYQMWKL GVVFTDNSFL
     YLAWYMTMSV LGHYNNFFFA AHLLDIAMGF KTLRTILSSV THNGKQLVLT VGLLAVVVYL
     YTVVAFNFFR KFYNKSEDGD MPDMKCDDML TCYMFHMYVG VRAGGGIGDE IEDPAGDEYE
     IYRIIFDITF FFFVIVILLA IIQGLIIDAF GELRDQQEQV KEDMETKCFI CGIGNDYFDT
     VPHGFETHTL QEHNLANYLF FLMYLINKDE TEHTGQESYV WKMYQERCWE FFPAGDCFRK
     QYEDQLN
//
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