ID A0A151M486_ALLMI Unreviewed; 3459 AA.
AC A0A151M486;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 08-NOV-2023, entry version 25.
DE SubName: Full=WD repeat and FYVE domain-containing protein 3 isoform B {ECO:0000313|EMBL:KYO19281.1};
GN Name=WDFY3 {ECO:0000313|EMBL:KYO19281.1};
GN ORFNames=Y1Q_0016282 {ECO:0000313|EMBL:KYO19281.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO19281.1};
RN [1] {ECO:0000313|EMBL:KYO19281.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO19281.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO19281.1}.
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DR EMBL; AKHW03006640; KYO19281.1; -; Genomic_DNA.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd06071; Beach; 1.
DR CDD; cd15719; FYVE_WDFY3; 1.
DR CDD; cd01201; PH_BEACH; 1.
DR Gene3D; 1.10.1540.10; BEACH domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR000409; BEACH_dom.
DR InterPro; IPR036372; BEACH_dom_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR023362; PH-BEACH_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR46108; BLUE CHEESE; 1.
DR PANTHER; PTHR46108:SF1; WD REPEAT AND FYVE DOMAIN-CONTAINING PROTEIN 3; 1.
DR Pfam; PF02138; Beach; 1.
DR Pfam; PF01363; FYVE; 1.
DR Pfam; PF14844; PH_BEACH; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM01026; Beach; 1.
DR SMART; SM00064; FYVE; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF81837; BEACH domain; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50197; BEACH; 1.
DR PROSITE; PS51783; PH_BEACH; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 2462..2587
FT /note="BEACH-type PH"
FT /evidence="ECO:0000259|PROSITE:PS51783"
FT DOMAIN 2614..2907
FT /note="BEACH"
FT /evidence="ECO:0000259|PROSITE:PS50197"
FT REPEAT 3054..3095
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 3388..3448
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT REGION 2338..2359
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2390..2453
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3202..3269
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2395..2409
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3228..3248
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3459 AA; 388041 MW; 16D957B2D3B2A05C CRC64;
MTQKEQEEKL YMMLPVFNRV FGNAPPSTMT EKFSDLLQFT TQVSRLMVTE IRRRASNKST
EAASRAIVQF LEINQSEEAS RGWMLLTTIN LLASSGQKTV DCMTTMSVPS TLVKCLYLFF
DLPHVPEVVG GAQNELPLAE RRALLQKVFV QILVKLCSFV SPAEELAQKD DLQLLFSAIT
SWCPPYNLPW RKSAGEVLMT ISRHGLSVNV VKYIHEKECL STCVQNMQQS DDLSPLEIVE
MFAGLSCFLK DSSDVSQTLL DDFRIWQGYN FLCDLLLRLE QAKEAESKDA LKDLVNLITS
LTTYGVNELK PAGVTTGAPF LLPGFAVPQP AGKGHSVRNI QAFSVLQNAF LKAKTSYLAQ
IILDAITNIY MADSANYFIL ESQHTLSQFA EKISKIPEVQ TKYFEMLEFV IFSLNYIPCK
ELISVSILLK SSTLYQCSIV AMKTLLKFTR HDYIFKDVFR EVGLLEVMVN ILHKYAALLK
DPTQALNDQG DSRNSSLEDQ KQLALLVMET LTVLLQGSNT NAGIFREFGG ARCVHNIVKY
PQCRPHALMI IQQLVLSPSG EDDMGTLLGL MHSAPPTELQ LKTDILRALL SVLRESHRTR
TVFRKVGGFV YVTSLLVAME RSLCSPPKNG WERVNQNQVF ELLHTVFCTL TAAMRYEPAN
SHFFKTEIQY EKLADAVRLL GCFSDSRKIS PLNVFPSNTQ LFQRLLEDDL ISMDSVSPML
RHCSKLFIYL YKVATDSFDR HAYHSVSAPP VYPPKNITDL KLLTGATSTQ SSDAVIIHPG
AMLAMLDLLA SVGLTTQPER ALDLQFAVAN ILQSLVHTDR NQQVMCEAGL HARLLQRCSA
ALADEDHSLH PPLQRMFERL ASQALEPMVL REFLRLGNPL NCGAWDKKLL KQYRVHKPSS
LSYEPEIRNS MVTSMEGLSS DSMFSLHEDN HYRISRSLLK PAEGSTVPLT RVKCLVSMTT
PHDIRLHGSS VTPAFIEFDT SLEGFGCLFL PSLAPHNAPT NNAVTTGLID GAVVSGIGTG
ERFFPPPSGL SYSTWFCIEH FSTAPNNHPV RLLTIVRRAN SSEQHYVCLA IVLSAKDRSL
IVSTKEELLQ NYVDDFSEES SFYEILPCCA RFRCGDLIVE GQWHHLVLVM SKGMLKNSTA
ALYIDGQLVN TVKLHYIHSS PGGSGSANPP VVSTVYSYIG TPPAQRQLSL LVWRLGPTHF
LEEVLPVSSV STVYELGPNY VGSFQAVYIP CKDSKSEGVS PSPVSLVPEE KVSFGLYALS
VSSLTVARIR KVYNKLDSKA IAKQLAVSSH ENATPVKLLH NSAGHLNGPA RTIGAALIGY
LGVRTFEPKP VATTLQYIGG AAAILGLVAM ASDVEGLYAA VKALVCVVKS NPLASKEMER
IKGYQLLAML LKKKRSLLNS HILHLTFSLV GTVDSGHETS IIPNSTAFQD LLCDFEVWLH
APYELHLSLF EHFIELLTES SEAAKNAKLM REFQLIPKLL LTLRDASLSQ PTIAAVSNVL
SFLLQGFPSS SDLLRFGQFI SSTLPTFAVC EKFVVMEINN EEKPDTGAED DFGGLVSANL
ILLRNRLLDI LLKLLYTSKE KTSVNLQACE ELVRTLGFDW IMMFMEEHLH STTVTGAMRI
LVVLLSNQPI LIKFKEGLSG GGWLDQTDSV LTNKIGTVLG FNVGRSAGGR STLREINRDA
CHFPGFPVLQ SLLPKHTNVP ALYFLLMALF LQQPVTELPE NLQVSAPVII SRCNQGCQFD
LDSIWTFIFG VPASSGTVVS SVHNVCTEAA FLLLGMLRSM LNSPWQSEEE GSWLREYPVT
LMQFFRYLYH NVPDLASLWM SPEFLCALAA TVFPFNIRPY SEMVTDLDDD VGSPAEEFKA
FAADSGMNRS QSEYCNVGSK TYLTNHPAKK FVFDFMRVLI IDNLCLTPAS KQTPLIDLLL
EASPERSTRT QQKEFQTYIL DSVMDHLLAA DVLLGEDASL PITTGGNYHV LVNNVFYFTQ
RVVDKLWQGM FNKESKLLVD FIIQLIAQSK RRSQGLSLDA IYHCLNRTIL YQFSRAHKTV
PQQVALLDSL RVFTVNRNLI LGPGNHDQEF ISCLAHCLIN LHVGSNVDGF GLEAEARMTT
WHIMIPSDIE PDGVYSQDVS EGRQLLLKAV NRVWTELIHS KKQVLEEAFK VTLPVNDRGQ
VDIVVARPCI EEASLKSWQN HLVHERKCIS RGEALVPTTQ SKLSRVSSGF GLSKLTGSRR
NRKESGLHKH NLSTQEISQW MFTHIAVVRD LIDMQYKEHQ ERQQNALKYV TEEWSQIEYE
LLRERGLWGP PIGSHLDKWM LEMTEGPCRM RKKMVRNDMF YIQYPYVPEA EQETNLLSDF
SSKPPETPDD TIPQKKPARY RRAISYDSKE YYMRLASGNP AVIQDTIEEN SEGEATQQEP
EHGEDTIARV KGLVKPPLKR SRSAPDGGDE ENQEQLQEQI SEGSSIDEEE KTDNTTLLRL
LEEGEKIQHM YRCARVQGLD TSEGLLLFGK EHFYVIDGFT MTVTREIRDI ETLPPNMHEP
IIPRGARQGP SQLKRTCSIF AYEDIKEVHK RRYLLQPIAV EVFSGDGRNY LLAFQKGVRN
KVYQRFLAVV PSLTDSSESV SGQRPNTSVE QGSGLLSTLV GEKSVTQRWE RGEISNFQYL
MHLNTLAGRS YNDLMQYPVF PWILADYDSE ELDLTNPKTF RNLAKPMGAQ TDERLAQYKK
RYKDWEDPNG ETPAYHYGTH YSSAMIVASY LVRMEPFTQI FLRLQGGHFD LADRMFHSVR
EAWYSASKHN MADVKELIPE FFYLPEFLLN SNNFDLGCKQ NGTKLGDVIL PPWAKGDPRE
FIRVHREALE CDFVSAHLHE WIDLIFGYKQ QGPAAVEAVN VFHHLFYEGQ VDIYNINDPL
KETATIGFIN NFGQIPKQLF KKPHPPKRVR SRINGETAGM SVPSGSTSDK IFFHHLDNLR
PSFAPVKELK EPVGQIVCTD KGILAVEQNK VLIPPAWNKT FAWGYADLSC RLGTYESDKA
VIVYECLSEW GQILCSICPN PKLVITGGTS TVVCVWEMGT SKEKAKTLAL KQALLGHTDT
VTCLTASIAY HIIVSGSRDR TCIIWDLNKL SFLTQLRGHW APVSALCINE LTGDIVSCAG
TYIHVWSING NPTASVNTFT GRSQQILCCC VSEMNEWDTQ NVIVTGHSDG VVRFWRMEFL
QVPETPAPEP VEILEMQEDC QEAQIGQEAQ EEDSSDSEAD DQCVSRDSKP QESQSQPSST
SQRPRSSSGR AAAAAWSADS GSDDSRRWSD QLSLDEKDGF IFVNYSEGQA KVHPHAQVNH
PHPNYIEVRH YSKLKPGYRW ERQLVFRSKL TMHTAFDRKD NAHPAEITAL GISKDHSRIL
VGDSRGRVFS WSVSDQPGRS AADHWVKDEG GDSCSGCSVR FSLTERRHHC RNCGQLFCQK
CSRFQSEIKR LKISSPVRVC QNCYYNLQHE RGSEEGPRN
//
