ID A0A151M500_ALLMI Unreviewed; 758 AA.
AC A0A151M500;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Breast cancer anti-estrogen resistance protein 3 {ECO:0008006|Google:ProtNLM};
GN ORFNames=Y1Q_0007516 {ECO:0000313|EMBL:KYO19595.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO19595.1};
RN [1] {ECO:0000313|EMBL:KYO19595.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO19595.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO19595.1}.
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DR EMBL; AKHW03006584; KYO19595.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A151M500; -.
DR STRING; 8496.A0A151M500; -.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001784; F:phosphotyrosine residue binding; IEA:InterPro.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd10337; SH2_BCAR3; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR044102; SH2_SHEP1/BCAR3/NSP1.
DR PANTHER; PTHR14247:SF10; BREAST CANCER ANTI-ESTROGEN RESISTANCE PROTEIN 3; 1.
DR PANTHER; PTHR14247; BREAST CANCER ANTI-ESTROGEN RESISTANCE PROTEIN 3 HOMOLOG-LIKE PROTEIN; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00017; SH2; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50001; SH2; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191}.
FT DOMAIN 85..184
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 478..748
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 233..349
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 233..253
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 280..316
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 332..346
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 758 AA; 85862 MW; 4545CAAEF5ED7D82 CRC64;
MGTLPYSRTP RQQASLIQDV IEEYPLQDRK SEKFHLRDQN MLDPAMEYVK FSKERQIMDI
TPEKLKKELE EELQLSSEDL RSHAWYHGRI PRQVAESLVQ RDGDFLIRDS LSSPGNFVLT
CQWKNISQHF KINRTVVRLS EAYCRVQYQF ELESFDSIPG LVRYHVGNRK PISKQSGAII
FQPINRTVPL RCLEEKYGVS PVRQRECSIS EGKSEAAKRL SLNVCGVQSR EHSLTRGNLL
RNKEKSGSQP ASLDHVQEKR FPLKAHQSES YLPIGSRHPS QVPETGTGSC PNSPISPFRT
GSEPTLSPTV VQRVASDSQA GEALRGSDSQ LCPKPPPKPS KVPLLKPPQS PLAWHSSEAH
YCELNPATPM DCGAAKQPSC QKSSYVEHLT AKENGALSFR NSETNYLILE DDASQRSMDP
LAAQNAMAEE GSMYVAPVLE TVSSFKPNDF ESKLLPLENK PLETSMLKRV KELFTNNDPK
IIAQHILRMD CKVARILEVS EEMRRIMGVS SGLELITLPY GHQLRLDLIE RHNTMAIGIA
VDILGCTGNL EERAATLNRI IQVAVELKDV LGDLYAFSAI MKALEMPQIS RLEQTWTTLR
HHYTQMAITY EKQLKPFSKA LHEGKETMCS PPNIVTVPLL MPLVTLMERQ AVTFEGMDLW
ENTDQSCEIM LKHLTAARSI AQHADMYRLT AERILEGFQP DEEMSEIFKT EFQMRLLWGS
KGAQVNQRER YEKFNQILNA LSRKLEPPPV KQVMKSEA
//
