GenomeNet

Database: UniProt
Entry: A0A151M723_ALLMI
LinkDB: A0A151M723_ALLMI
Original site: A0A151M723_ALLMI 
ID   A0A151M723_ALLMI        Unreviewed;      1551 AA.
AC   A0A151M723;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   24-JAN-2024, entry version 37.
DE   RecName: Full=Rap guanine nucleotide exchange factor 2 {ECO:0000256|ARBA:ARBA00016709};
DE   AltName: Full=Cyclic nucleotide ras GEF {ECO:0000256|ARBA:ARBA00031545};
DE   AltName: Full=Neural RAP guanine nucleotide exchange protein {ECO:0000256|ARBA:ARBA00032021};
DE   AltName: Full=PDZ domain-containing guanine nucleotide exchange factor 1 {ECO:0000256|ARBA:ARBA00030673};
DE   AltName: Full=RA-GEF-1 {ECO:0000256|ARBA:ARBA00029925};
DE   AltName: Full=Ras/Rap1-associating GEF-1 {ECO:0000256|ARBA:ARBA00031980};
GN   Name=RAPGEF2 {ECO:0000313|EMBL:KYO20271.1};
GN   ORFNames=Y1Q_0010813 {ECO:0000313|EMBL:KYO20271.1};
OS   Alligator mississippiensis (American alligator).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC   Alligator.
OX   NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO20271.1};
RN   [1] {ECO:0000313|EMBL:KYO20271.1, ECO:0000313|Proteomes:UP000050525}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO20271.1};
RX   PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA   St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA   Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA   Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA   Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA   Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA   McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA   Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA   Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA   Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA   Ray D.A.;
RT   "Sequencing three crocodilian genomes to illuminate the evolution of
RT   archosaurs and amniotes.";
RL   Genome Biol. 13:415-415(2012).
CC   -!- SUBCELLULAR LOCATION: Cell junction {ECO:0000256|ARBA:ARBA00004282}.
CC       Cell membrane {ECO:0000256|ARBA:ARBA00004236}. Cytoplasm, perinuclear
CC       region {ECO:0000256|ARBA:ARBA00004556}. Endosome
CC       {ECO:0000256|ARBA:ARBA00004177}. Late endosome
CC       {ECO:0000256|ARBA:ARBA00004603}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004370}.
CC   -!- SIMILARITY: Belongs to the RAPGEF2 family.
CC       {ECO:0000256|ARBA:ARBA00010829}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KYO20271.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AKHW03006437; KYO20271.1; -; Genomic_DNA.
DR   RefSeq; XP_019333914.1; XM_019478369.1.
DR   GeneID; 102557740; -.
DR   CTD; 51735; -.
DR   OrthoDB; 5473909at2759; -.
DR   Proteomes; UP000050525; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd00038; CAP_ED; 1.
DR   CDD; cd00992; PDZ_signaling; 1.
DR   CDD; cd01785; RA_PDZ-GEF1; 1.
DR   CDD; cd00155; RasGEF; 1.
DR   CDD; cd06224; REM; 1.
DR   Gene3D; 2.30.42.10; -; 1.
DR   Gene3D; 2.60.120.10; Jelly Rolls; 2.
DR   Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR   Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR018490; cNMP-bd_dom_sf.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR000159; RA_dom.
DR   InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR45161:SF2; CYCLIC NUCLEOTIDE RAS GEF; 1.
DR   PANTHER; PTHR45161; CYTOSKELETON-ASSOCIATED PROTEIN 4; 1.
DR   Pfam; PF00027; cNMP_binding; 1.
DR   Pfam; PF00595; PDZ; 1.
DR   Pfam; PF00788; RA; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   Pfam; PF00618; RasGEF_N; 1.
DR   SMART; SM00100; cNMP; 2.
DR   SMART; SM00228; PDZ; 1.
DR   SMART; SM00314; RA; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SMART; SM00229; RasGEFN; 1.
DR   SUPFAM; SSF51206; cAMP-binding domain-like; 2.
DR   SUPFAM; SSF50156; PDZ domain-like; 1.
DR   SUPFAM; SSF48366; Ras GEF; 1.
DR   SUPFAM; SSF54236; Ubiquitin-like; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
DR   PROSITE; PS50106; PDZ; 1.
DR   PROSITE; PS50200; RA; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
DR   PROSITE; PS50212; RASGEF_NTER; 1.
PE   3: Inferred from homology;
KW   Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW   Endosome {ECO:0000256|ARBA:ARBA00022753};
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW   ECO:0000256|PROSITE-ProRule:PRU00168};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Neurogenesis {ECO:0000256|ARBA:ARBA00022902};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000050525}.
FT   DOMAIN          282..382
FT                   /note="Cyclic nucleotide-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS50042"
FT   DOMAIN          414..527
FT                   /note="N-terminal Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50212"
FT   DOMAIN          532..602
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   DOMAIN          752..838
FT                   /note="Ras-associating"
FT                   /evidence="ECO:0000259|PROSITE:PS50200"
FT   DOMAIN          863..1090
FT                   /note="Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50009"
FT   REGION          178..246
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1077..1103
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1155..1188
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1208..1292
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1475..1496
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1521..1551
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        178..210
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        226..243
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1077..1092
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1170..1188
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1214..1228
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1241..1292
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1521..1543
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1551 AA;  174630 MW;  8111133A4ADA9266 CRC64;
     MGSAVDPKVQ QALRKKPPER SREDLNIIYT YLHGMDILSH LREHQLRIMS SSARYERYKG
     NQVLFCSETI ARCWYILLSG SVLMKDSMFL PPCSFGKQSG GKRGCECIVL EPSEMIVVEN
     SKDNEENILQ REVPIRQSRR RFRKINQRGE RQTITDHVDA SSYLSLPADL TKMQIADNPH
     PQVTHVPSSQ SGCSIASDSG SSSLSDIYQA TESEMGDVDL TGLPEAPVDS EDEEEEEDED
     IDRTSDPLLG RDVVRECLEK EPADKTDDDI EQLLEFMHQL PAFANMTMSV RRELCSVMIF
     EVVEQAGAII LEDGQELDSW YVILNGTVEI SYPDGKTENL CMGNSFGITP SLEKQYMNGV
     VRTKVDDCQF VCIAQQDYWR ILNHVEKNTH KVEEEGEIVM VKEHRELDRS GTRKGHIVIK
     ATPERLITHL IEEHSIVDPT YIEDFLLTYR TFLSSPLEVG DKLLEWFKID SLRDKVTRVV
     LLWVNNHFND FEGDPAMTRF LEEFEKNLEN TKMKGHLRLL NIACAAKAKW RQITLQKASR
     DSPLYFSLLG GSEKGFGIFV ETVETGSKAA EVGLKRGDQI MEVNGQNFEN ITFVKALEIL
     RNNTHLSITV KTNIFVFKEL LSRIGQEKNG VPHIPKIAEK KNNRYSIPDM PGDMEQIFPR
     EKGNKKMKAN TVSGGRNRIK KILDKTRFSI LPPKLFSDGS VSQSQDDSIV GTRQCRHSLA
     IMPVPGTLSS SSPDLLQPTT SILDFSNPSD IPDQVIRVFK ADQQSCYIII SKDTTAKEVV
     SHAVHEFNLT GASETYSLCE VSVSPEGVIK QRRLPDQFSK LADRIQLNGR YYLKNNMETE
     TLCSDEDAQE LLRESQISLL QLSTIEVATQ LSMRDFELFR NIEPTEYIDD LFKLDSKTGN
     AHLKQFEDVI NQETFWVATE ILLEPNQLKR MKIIKHFIKI ALHCRECKNF NSMFAVISGL
     NLASVARLRG TWEKLPSKYE KHFRDLQDLF DPSRNMAKYR NILSSQSMQP PIIPLFPVVK
     KDITFLHEGN DSKVDGLVNF EKLRMIAKEI RQVIRMTSAN MDPAVMFRQR KKRWRSLGSL
     SQGSTNSNML DVQGGAHKKR ARRSSLLNAK KLYEDAQMAR KVKQYLSNLN VETDEEKFQI
     MSLQCEPAYS TLTKNLSERR GGKSSEMSPI PLRSVGQTTK VQQHQQNRMS QVLQVPAVNL
     YPIRKKGPAK DHVTFNTGSP QKSLSLSEEV SKKPAEDAVS MASSLHSSPL ASPQGSPRKV
     GNIQRSDNCS QMNLSGSSSS LASETSNKNS GQRSYGIGYA LIPSAKSDNF SDSSHSEISS
     RSSIVSNCSV DSMSAALQDE RGLPQSLSVV DSVGTERKEH PPPLAEYSQP CPGWPLPRPA
     IIRGLAVTSS MSNEEISHEH ITIEAADSGR GSWTSCSSSS HDNFQNIQIQ KSWDLLNSYR
     HTHLDGPIAE VEPTNCYPEE AYLYSEAFSK NNRQSKTSVE LDQSRQSWAS SSSLSDTYET
     NYGTIKRRGL ENSTMEQTEI LDSKPGTDAT YKTVTSSTEK GLIEDEQVSA V
//
DBGET integrated database retrieval system