ID A0A151M723_ALLMI Unreviewed; 1551 AA.
AC A0A151M723;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 24-JAN-2024, entry version 37.
DE RecName: Full=Rap guanine nucleotide exchange factor 2 {ECO:0000256|ARBA:ARBA00016709};
DE AltName: Full=Cyclic nucleotide ras GEF {ECO:0000256|ARBA:ARBA00031545};
DE AltName: Full=Neural RAP guanine nucleotide exchange protein {ECO:0000256|ARBA:ARBA00032021};
DE AltName: Full=PDZ domain-containing guanine nucleotide exchange factor 1 {ECO:0000256|ARBA:ARBA00030673};
DE AltName: Full=RA-GEF-1 {ECO:0000256|ARBA:ARBA00029925};
DE AltName: Full=Ras/Rap1-associating GEF-1 {ECO:0000256|ARBA:ARBA00031980};
GN Name=RAPGEF2 {ECO:0000313|EMBL:KYO20271.1};
GN ORFNames=Y1Q_0010813 {ECO:0000313|EMBL:KYO20271.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO20271.1};
RN [1] {ECO:0000313|EMBL:KYO20271.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO20271.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- SUBCELLULAR LOCATION: Cell junction {ECO:0000256|ARBA:ARBA00004282}.
CC Cell membrane {ECO:0000256|ARBA:ARBA00004236}. Cytoplasm, perinuclear
CC region {ECO:0000256|ARBA:ARBA00004556}. Endosome
CC {ECO:0000256|ARBA:ARBA00004177}. Late endosome
CC {ECO:0000256|ARBA:ARBA00004603}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
CC -!- SIMILARITY: Belongs to the RAPGEF2 family.
CC {ECO:0000256|ARBA:ARBA00010829}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO20271.1}.
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DR EMBL; AKHW03006437; KYO20271.1; -; Genomic_DNA.
DR RefSeq; XP_019333914.1; XM_019478369.1.
DR GeneID; 102557740; -.
DR CTD; 51735; -.
DR OrthoDB; 5473909at2759; -.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd01785; RA_PDZ-GEF1; 1.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 2.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR45161:SF2; CYCLIC NUCLEOTIDE RAS GEF; 1.
DR PANTHER; PTHR45161; CYTOSKELETON-ASSOCIATED PROTEIN 4; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00100; cNMP; 2.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00314; RA; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 2.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 3: Inferred from homology;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Neurogenesis {ECO:0000256|ARBA:ARBA00022902};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525}.
FT DOMAIN 282..382
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 414..527
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 532..602
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 752..838
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 863..1090
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 178..246
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1077..1103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1155..1188
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1208..1292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1475..1496
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1521..1551
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 178..210
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 226..243
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1077..1092
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1170..1188
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1214..1228
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1241..1292
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1521..1543
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1551 AA; 174630 MW; 8111133A4ADA9266 CRC64;
MGSAVDPKVQ QALRKKPPER SREDLNIIYT YLHGMDILSH LREHQLRIMS SSARYERYKG
NQVLFCSETI ARCWYILLSG SVLMKDSMFL PPCSFGKQSG GKRGCECIVL EPSEMIVVEN
SKDNEENILQ REVPIRQSRR RFRKINQRGE RQTITDHVDA SSYLSLPADL TKMQIADNPH
PQVTHVPSSQ SGCSIASDSG SSSLSDIYQA TESEMGDVDL TGLPEAPVDS EDEEEEEDED
IDRTSDPLLG RDVVRECLEK EPADKTDDDI EQLLEFMHQL PAFANMTMSV RRELCSVMIF
EVVEQAGAII LEDGQELDSW YVILNGTVEI SYPDGKTENL CMGNSFGITP SLEKQYMNGV
VRTKVDDCQF VCIAQQDYWR ILNHVEKNTH KVEEEGEIVM VKEHRELDRS GTRKGHIVIK
ATPERLITHL IEEHSIVDPT YIEDFLLTYR TFLSSPLEVG DKLLEWFKID SLRDKVTRVV
LLWVNNHFND FEGDPAMTRF LEEFEKNLEN TKMKGHLRLL NIACAAKAKW RQITLQKASR
DSPLYFSLLG GSEKGFGIFV ETVETGSKAA EVGLKRGDQI MEVNGQNFEN ITFVKALEIL
RNNTHLSITV KTNIFVFKEL LSRIGQEKNG VPHIPKIAEK KNNRYSIPDM PGDMEQIFPR
EKGNKKMKAN TVSGGRNRIK KILDKTRFSI LPPKLFSDGS VSQSQDDSIV GTRQCRHSLA
IMPVPGTLSS SSPDLLQPTT SILDFSNPSD IPDQVIRVFK ADQQSCYIII SKDTTAKEVV
SHAVHEFNLT GASETYSLCE VSVSPEGVIK QRRLPDQFSK LADRIQLNGR YYLKNNMETE
TLCSDEDAQE LLRESQISLL QLSTIEVATQ LSMRDFELFR NIEPTEYIDD LFKLDSKTGN
AHLKQFEDVI NQETFWVATE ILLEPNQLKR MKIIKHFIKI ALHCRECKNF NSMFAVISGL
NLASVARLRG TWEKLPSKYE KHFRDLQDLF DPSRNMAKYR NILSSQSMQP PIIPLFPVVK
KDITFLHEGN DSKVDGLVNF EKLRMIAKEI RQVIRMTSAN MDPAVMFRQR KKRWRSLGSL
SQGSTNSNML DVQGGAHKKR ARRSSLLNAK KLYEDAQMAR KVKQYLSNLN VETDEEKFQI
MSLQCEPAYS TLTKNLSERR GGKSSEMSPI PLRSVGQTTK VQQHQQNRMS QVLQVPAVNL
YPIRKKGPAK DHVTFNTGSP QKSLSLSEEV SKKPAEDAVS MASSLHSSPL ASPQGSPRKV
GNIQRSDNCS QMNLSGSSSS LASETSNKNS GQRSYGIGYA LIPSAKSDNF SDSSHSEISS
RSSIVSNCSV DSMSAALQDE RGLPQSLSVV DSVGTERKEH PPPLAEYSQP CPGWPLPRPA
IIRGLAVTSS MSNEEISHEH ITIEAADSGR GSWTSCSSSS HDNFQNIQIQ KSWDLLNSYR
HTHLDGPIAE VEPTNCYPEE AYLYSEAFSK NNRQSKTSVE LDQSRQSWAS SSSLSDTYET
NYGTIKRRGL ENSTMEQTEI LDSKPGTDAT YKTVTSSTEK GLIEDEQVSA V
//