ID A0A151MB52_ALLMI Unreviewed; 2029 AA.
AC A0A151MB52;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=TOG domain-containing protein {ECO:0000259|SMART:SM01349};
GN ORFNames=Y1Q_0000466 {ECO:0000313|EMBL:KYO21757.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO21757.1};
RN [1] {ECO:0000313|EMBL:KYO21757.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO21757.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- SIMILARITY: Belongs to the TOG/XMAP215 family.
CC {ECO:0000256|ARBA:ARBA00025722}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO21757.1}.
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DR EMBL; AKHW03006283; KYO21757.1; -; Genomic_DNA.
DR STRING; 8496.A0A151MB52; -.
DR eggNOG; KOG1820; Eukaryota.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0000776; C:kinetochore; IEA:UniProtKB-KW.
DR GO; GO:0061863; F:microtubule plus end polymerase; IEA:InterPro.
DR GO; GO:0051010; F:microtubule plus-end binding; IEA:InterPro.
DR GO; GO:0030951; P:establishment or maintenance of microtubule cytoskeleton polarity; IEA:InterPro.
DR GO; GO:0046785; P:microtubule polymerization; IEA:InterPro.
DR GO; GO:0007051; P:spindle organization; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 5.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR024395; CLASP_N_dom.
DR InterPro; IPR034085; TOG.
DR InterPro; IPR045110; XMAP215.
DR InterPro; IPR048491; XMAP215_CLASP_TOG.
DR PANTHER; PTHR12609:SF0; CYTOSKELETON-ASSOCIATED PROTEIN 5; 1.
DR PANTHER; PTHR12609; MICROTUBULE ASSOCIATED PROTEIN XMAP215; 1.
DR Pfam; PF12348; CLASP_N; 1.
DR Pfam; PF21041; XMAP215_CLASP_TOG; 4.
DR SMART; SM01349; TOG; 5.
DR SUPFAM; SSF48371; ARM repeat; 2.
PE 3: Inferred from homology;
KW Kinetochore {ECO:0000256|ARBA:ARBA00022838};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525}.
FT DOMAIN 1..220
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT DOMAIN 263..497
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT DOMAIN 580..812
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT DOMAIN 843..1075
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT DOMAIN 1184..1422
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT REGION 499..572
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 806..838
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1071..1150
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1413..1450
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1989..2029
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1096..1110
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1431..1450
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1991..2014
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2029 AA; 224741 MW; 05D7005BAB4A4E2C CRC64;
MKLPIDQKCE HKLWKARLNG YEEALKLFQK IDDEKSPEWS KYLGLIKKFV TDSNAVAQLK
GLEAALAYVE NAHVAGKTTG EVVSGVVNKV FNQPKARAKE LGIDMCLMYI EIEKGEPVQE
ELLKGLDNKN PKIIVACIET LRKALSEFGS KIISLKPIIK VLPKLFESRE KAVRDEAKLL
AVEIYRWIRD ALRPPLQNIN SVQLKELEEE WVKVQPAAPK QTRFLRSQQE LKAKFEQQQA
AGGDADGGGD DGDEVVPQVD AYELLEAVEI LSKLPKDFYD KIEAKKWQER KEALEAVEIL
VKNPKLEAGD YADLVRVLKK VVGKDTNVML VALAAKCLAG LATGLRKKFG QYAGHVVPTI
LEKFKEKKPQ VVQALQEAID AIFLTTTLQN ISEDVLAVMD NKNPTIKQQT SLFIARSFRH
CTPSTLPKNL LKPFCAALLK HINDSAPEVR DAAFEALGTA LKVAGEKAVN PFLTDVDKLK
LDRIKECAEK VELACGKKAG GAADKKEGKT LPGKTPVVSG AAGDKDTKET SAKSGPPKKA
PVVKPGGPPK KGKPAATAGM GGAGTKGKKG PETKEIFESE LSIEVCEEKA AAVLPASCIQ
QLDSGNWKER LACMEEFQKA VELMEKNEMP CQALVRMLAK KPGWKETNFQ VMQMKLHIVA
LIAQKGNFSK TSAQIVLDGL VDKIGDVKCG SNAKEAMTAI AEACQLPWTA EQVMAMAFSQ
KNPKNQSETL NWLSNAIKEF GFSGLNVKAF ISNVKTALAA TNPAVRTSAI TLLGVMYLYV
GPPLRMFFED EKPALLSQID AEFEKMQGQT TPAPTRGVSR HSGGNGDDGE EEEQEDVGSD
VVDLLPRADI SEKITSELVS KIGDKNWKIR KEGLDEVASI INDAKFIQPN LGELPAALKS
RLNDSNKILV QQTLSILQQL AIAVGPNIRQ HVKNLGIPII TVLGDSKNNV RATALATVNA
WAEQTGMKEW LEGEDLSEEL KKENPFLRQE LLGWLAEKLP TLRSVPSDLL LCVPHLYSCL
EDRNGDVRKK AQDALPFFMM HLGFEKMAKA TGKLKPTSKD QVLTMLEKAK ANMPAKPAAP
AKASSRMAGG AAPAKFQSTS APTDDSGSST MEYKPDPKKA KAGGAASKAK GIQGKKVPSK
PNLKEDEDKS GPVFIIVPNG KEQRMRDEKG LKVLKWNFTT PRDEYIEQLK TQMSSCVARW
LQDEMFHADF QHHNKALTVM IEHLESEKDG IISCLDLILK WLTLRFFETN TSVLMKALEY
LKLLFTLLSQ EEYHLTENEA SSFIPYLILK VGEPKDVVRK DVRAILNRMC LIYPASKMFT
FLMEGTKSKN SKQRAECLEE LGCLVESYGM NVCQPTPGKA LKEMAAHIGD RDNTVRNAAL
NTIVTVYNVH GDQVFKLIGN LSEKDMSMLE ERIKRSAKRP AAAPARQVEE KPQRLQTTSA
NTSMLRKGSA EDMSSKLSQA RNMSGHSETM HAVPREFQLD LDEIENDNGT VRCEMPTLVQ
HKLDDIFEPV LIPEPKIRAV SPHFDDMHSN TASTINFVIS QVASGDINTS IQALAQIDEV
LRQEDKAEAM SGHIDQFLIA TFMQLRLIYN THMADEKLDK DEIVKLYSCI IGNMISLFQI
ESLAREASTG VLKDLMHGLI TLMLDSRVED LEEGQQVIRS VNLLVVKVLE KSDQTNILSA
LLVLLQDSLL ATASSPKFSE LVMKCLWRMV RLLPETINSI NLDRILLDIH VFMKVFPKEK
LKQCKSEFPI RTLKTLLHTL CKLKGPKILD HLTMIDNKNE SELEAHLCRV MKHSMDQTGS
KADKDTEKGA SHIDEKASKA KVNDILAEIF KKIGSKENTK EGLAELYEYK KKYSDADIEP
FLKNSSQFFQ SYVERGLRLI EMEREGKGRI PSSTGISPQM EVTCVPTSTS TVSSSIGNTN
GEEVGPSVYL ERLKILRQRC GLDNAKQEDR APLTSLLSKP AVPTVASSTD MLHSKLSQLR
ESREQYQHLD LDSNQTHSSG IGTTTSSSST AANIDDLKKR LERIKSSRK
//
