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Database: UniProt
Entry: A0A151MBU5_ALLMI
LinkDB: A0A151MBU5_ALLMI
Original site: A0A151MBU5_ALLMI 
ID   A0A151MBU5_ALLMI        Unreviewed;      1378 AA.
AC   A0A151MBU5;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   25-OCT-2017, entry version 9.
DE   SubName: Full=Two pore calcium channel protein 2 isoform B {ECO:0000313|EMBL:KYO21890.1};
GN   Name=TPCN2 {ECO:0000313|EMBL:KYO21890.1};
GN   ORFNames=Y1Q_0000560 {ECO:0000313|EMBL:KYO21890.1};
OS   Alligator mississippiensis (American alligator).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC   Alligator.
OX   NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO21890.1};
RN   [1] {ECO:0000313|EMBL:KYO21890.1, ECO:0000313|Proteomes:UP000050525}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO21890.1};
RX   PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA   St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y.,
RA   Gongora J., Dalzell P., Moran C., Bed'hom B., Abzhanov A.,
RA   Burgess S.C., Cooksey A.M., Castoe T.A., Crawford N.G., Densmore L.D.,
RA   Drew J.C., Edwards S.V., Faircloth B.C., Fujita M.K., Greenwold M.J.,
RA   Hoffmann F.G., Howard J.M., Iguchi T., Janes D.E., Khan S.Y.,
RA   Kohno S., de Koning A.J., Lance S.L., McCarthy F.M., McCormack J.E.,
RA   Merchant M.E., Peterson D.G., Pollock D.D., Pourmand N., Raney B.J.,
RA   Roessler K.A., Sanford J.R., Sawyer R.H., Schmidt C.J., Triplett E.W.,
RA   Tuberville T.D., Venegas-Anaya M., Howard J.T., Jarvis E.D.,
RA   Guillette L.J.Jr., Glenn T.C., Green R.E., Ray D.A.;
RT   "Sequencing three crocodilian genomes to illuminate the evolution of
RT   archosaurs and amniotes.";
RL   Genome Biol. 13:415-415(2012).
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KYO21890.1}.
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DR   EMBL; AKHW03006283; KYO21890.1; -; Genomic_DNA.
DR   Proteomes; UP000050525; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016810; F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds; IEA:InterPro.
DR   GO; GO:0072345; F:NAADP-sensitive calcium-release channel activity; IEA:InterPro.
DR   GO; GO:0003952; F:NAD+ synthase (glutamine-hydrolyzing) activity; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   GO; GO:0009435; P:NAD biosynthetic process; IEA:InterPro.
DR   CDD; cd00553; NAD_synthase; 1.
DR   Gene3D; 3.40.50.620; -; 1.
DR   Gene3D; 3.60.110.10; -; 1.
DR   InterPro; IPR003010; C-N_Hydrolase.
DR   InterPro; IPR036526; C-N_Hydrolase_sf.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR022310; NAD/GMP_synthase.
DR   InterPro; IPR003694; NAD_synthase.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   InterPro; IPR028798; TPC2.
DR   PANTHER; PTHR10037:SF92; PTHR10037:SF92; 1.
DR   Pfam; PF00795; CN_hydrolase; 1.
DR   Pfam; PF00520; Ion_trans; 2.
DR   Pfam; PF02540; NAD_synthase; 1.
DR   SUPFAM; SSF56317; SSF56317; 1.
DR   TIGRFAMs; TIGR00552; nadE; 1.
DR   PROSITE; PS50263; CN_HYDROLASE; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000050525};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    710    728       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    757    775       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    787    807       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    845    867       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    918    940       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1060   1082       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1094   1113       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1134   1153       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1173   1196       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1208   1228       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1301   1323       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN        5    270       CN hydrolase. {ECO:0000259|PROSITE:
FT                                PS50263}.
SQ   SEQUENCE   1378 AA;  156981 MW;  F90B1EFCA639B5E7 CRC64;
     MARAVTVATC ALNQWALDFD GNLERILRSI EIAKHKGARY RLGPELEICG YGCSDHYYES
     DTLLHSFQVL AKLLESPAAQ DIICDVGMPV MHRNIRYSCR VIFLNKHVEE YFLPRMIQEV
     TGQETVPFGD AVLATKDTCL GTEICEELWA PNSPHIEMGL DGVEIFTNSS GSHHVLQKAY
     IRVDLVNSAT AKNGGIYILA NQKGCDGDRL YYDGCAMISV NGDTVAQGSQ FSLDDVEVLV
     ATLDLEDVRT YRAEISSRNL LASRVNSYPR VKVNFALSCS DEICVSISEP IQWRYHSPEE
     EICLGPACWL WDYLRRSKQA GFLLPLSGGT DSSATACIVY SMCHQVCLAV KNGNQGVLTD
     VRRIVNEDTY TPEVPQEFCR RIFTTCYMAS ENSSQDTRNR AKFLAEQIGS YHINLNIDVA
     VKAIVGIFSI VMGKSPQFRV YGGSSRENLA LQNVQARLRM VLAYLFAQLS LWARGMPGGL
     LVLGSANVDE SLRGYLTKYD CSSADLNPIG GISKTDLKSF LQYCIENFQL TSLRSILSAL
     PTAELEPLAD GQVSQIDEMD MGMTYAELSI YGKLRKVAKA GPYSMFCKLI NMWKEICSPR
     EVASKVKHFF RMYSVNRHKM TTLTPAYHAE NYSPDDNRFD LRPFLYNSAW SWQFRCIDKQ
     VSKLETAGAD CDLYINQAVV FIEDAIQYRS INHRVDSKSL WLYRWYYSRI CQWILGLTIT
     IILGLAFIET PSSLTVTSDI RYRSPAWEPP CGLTESIELL CFLIFIADVS VKSYLIGWEE
     FRKTKWLMAY ILALVVSLTD WTVSMSFSCR ETVRIRRILR PFFLLQNSSM MKKTLKSINS
     TLPEMASVVL LLAVHLSLFT MFGMLLFART KDGQQDKEWL GYFRNLPDAL TSLLVLLTTA
     NNPDVMIPAY SKNRAYSIFF VLFTVLGNLF LMNLLTAIIY NQFRGYLLKS VQSSLLRRRL
     GIRAAFEVLC SLKETPAHTH ELCVNAETLL RVLKKVDMDF GCKHVILRTL RTCPHGLLSA
     VQFQKLFEEL DKDSVKQHPA KPEYQSPFLQ KMQFAFGHPY FSYTGNVVAL ANIISICVVL
     VIDADKQPSE RDDFFLGAIN FFFILYYLLE MLLKIMAMGL RRYLSYPSNR FDGLLTGILL
     VLEISTFAVY GFPHPGWRPE MMGLLSLWDM VRLVNMLIVF RFLRIIPNMK FMALVISTLL
     DLVKNLRAFA GILLVVYYAF ALIGIALFKG AIVPMGNISV VNITSGNNTL QCGTYEQLEY
     WPNNFDDFAA ALVTLWDVMV VNNWQVFLDA FSRYSSPWSK LYFVAWWLIS SVIWVNLFVA
     LLLENFIHKW DRRCQQQSLS EIEYQVTMEL MFRDVLEEPT EEELMEKLYQ HPHLQLCR
//
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