ID A0A151MF41_ALLMI Unreviewed; 506 AA.
AC A0A151MF41;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=Ectonucleoside triphosphate diphosphohydrolase 2 {ECO:0000313|EMBL:KYO23121.1};
GN Name=ENTPD2 {ECO:0000313|EMBL:KYO23121.1};
GN ORFNames=Y1Q_0005571 {ECO:0000313|EMBL:KYO23121.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO23121.1};
RN [1] {ECO:0000313|EMBL:KYO23121.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO23121.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- SIMILARITY: Belongs to the GDA1/CD39 NTPase family.
CC {ECO:0000256|ARBA:ARBA00009283, ECO:0000256|RuleBase:RU003833}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO23121.1}.
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DR EMBL; AKHW03006215; KYO23121.1; -; Genomic_DNA.
DR RefSeq; XP_006264909.3; XM_006264847.3.
DR AlphaFoldDB; A0A151MF41; -.
DR STRING; 8496.A0A151MF41; -.
DR GeneID; 102570477; -.
DR KEGG; amj:102570477; -.
DR CTD; 954; -.
DR eggNOG; KOG1386; Eukaryota.
DR OrthoDB; 180318at2759; -.
DR PhylomeDB; A0A151MF41; -.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 1.
DR Gene3D; 3.30.420.40; -; 1.
DR Gene3D; 3.30.420.150; Exopolyphosphatase. Domain 2; 1.
DR InterPro; IPR000407; GDA1_CD39_NTPase.
DR PANTHER; PTHR11782; ADENOSINE/GUANOSINE DIPHOSPHATASE; 1.
DR PANTHER; PTHR11782:SF33; ECTONUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE 2; 1.
DR Pfam; PF01150; GDA1_CD39; 1.
DR PROSITE; PS01238; GDA1_CD39_NTPASE; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW Hydrolase {ECO:0000256|RuleBase:RU003833, ECO:0000313|EMBL:KYO23121.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 475..497
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT ACT_SITE 171
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR600407-1"
FT BINDING 210..214
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR600407-2"
SQ SEQUENCE 506 AA; 56021 MW; 3EE43BE61D1358E7 CRC64;
MRQRAGSMVP RRVLAALLLL CLAGVVGILL LCLPTTDLRQ PPGFKYGIVL DAGSSHTAMF
VYKWPADKEN DTGIVSQHSM CDVKGGGISS YAKEPSGAGN SLKLCLNQAL KDVPKEKHSV
TPLYLGATAG MRLLNITNSQ ESHDVLSSVT SMLKSYPFDF RGAKILSGED EGVFGWVTAN
YLLENFIKYG WIGQWIHPKK GTLGAMDLGG ASTQITFETM EQIENPQNEV TLRLYGQTYK
VYTHSFLCYG RDQVLKRLLS KVLKAEEYKP DISNPCWPKG YRKQLSLGDV YNSPCTSTEQ
PNNYDSKAAV TMVGSGDAAK CRLHVESLFR FSNCSFSRCS FDGIFQPSVS GNFIAFSAFF
YTVNFIQSVM KRHVASPRDL EEAAQAICNT TWSQLVELAP GQEKRLPDYC ITSTFVYLLT
TKGYQFDDST FSNIAFQKKA GDTSIGWALG YMLNLTNMIP ADEAGFRKGT EYSSWVVLIL
LFVVIILIAL AAIFCLVRPN KERDAI
//
