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Database: UniProt
Entry: A0A151MF55_ALLMI
LinkDB: A0A151MF55_ALLMI
Original site: A0A151MF55_ALLMI 
ID   A0A151MF55_ALLMI        Unreviewed;      2359 AA.
AC   A0A151MF55;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   20-DEC-2017, entry version 12.
DE   RecName: Full=Voltage-dependent N-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   ORFNames=Y1Q_0005596 {ECO:0000313|EMBL:KYO23156.1};
OS   Alligator mississippiensis (American alligator).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC   Alligator.
OX   NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO23156.1};
RN   [1] {ECO:0000313|EMBL:KYO23156.1, ECO:0000313|Proteomes:UP000050525}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO23156.1};
RX   PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA   St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y.,
RA   Gongora J., Dalzell P., Moran C., Bed'hom B., Abzhanov A.,
RA   Burgess S.C., Cooksey A.M., Castoe T.A., Crawford N.G., Densmore L.D.,
RA   Drew J.C., Edwards S.V., Faircloth B.C., Fujita M.K., Greenwold M.J.,
RA   Hoffmann F.G., Howard J.M., Iguchi T., Janes D.E., Khan S.Y.,
RA   Kohno S., de Koning A.J., Lance S.L., McCarthy F.M., McCormack J.E.,
RA   Merchant M.E., Peterson D.G., Pollock D.D., Pourmand N., Raney B.J.,
RA   Roessler K.A., Sanford J.R., Sawyer R.H., Schmidt C.J., Triplett E.W.,
RA   Tuberville T.D., Venegas-Anaya M., Howard J.T., Jarvis E.D.,
RA   Guillette L.J.Jr., Glenn T.C., Green R.E., Ray D.A.;
RT   "Sequencing three crocodilian genomes to illuminate the evolution of
RT   archosaurs and amniotes.";
RL   Genome Biol. 13:415-415(2012).
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1B
CC       gives rise to N-type calcium currents. N-type calcium channels
CC       belong to the 'high-voltage activated' (HVA) group and are blocked
CC       by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin-
CC       IIIA (omega-Aga-IIIA). They are however insensitive to
CC       dihydropyridines (DHP), and omega-agatoxin-IVA (omega-Aga-IVA).
CC       Calcium channels containing alpha-1B subunit may play a role in
CC       directed migration of immature neurons.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KYO23156.1}.
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DR   EMBL; AKHW03006215; KYO23156.1; -; Genomic_DNA.
DR   Proteomes; UP000050525; Unassembled WGS sequence.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005447; VDCC_N_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF161; PTHR10037:SF161; 1.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01631; NVDCCALPHA1.
DR   SMART; SM01062; Ca_chan_IQ; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000050525};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM     89    106       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    127    148       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    160    180       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    215    237       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    291    312       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    324    346       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    475    495       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    501    518       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    600    622       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    678    700       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1168   1187       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1207   1228       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1240   1258       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1301   1323       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1413   1438       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1494   1512       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1524   1547       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1616   1643       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1703   1727       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1743   1778       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      354    374       {ECO:0000256|SAM:Coils}.
FT   COILED      709    736       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2359 AA;  267514 MW;  A3DAF3B09574BF16 CRC64;
     MARFGEELPS RYGGGGPAAA GRGSSRQGGP QPGQRVYKQS MAQRARTMAL YNPIPVKQNC
     FTVNRSLFIF SEDNIIRKYA KRITEWPPFE YMILATIIAN CIVLALEQHL PDGDKTPMSE
     RLDDTEPYFI GIFCFEAGIK IIALGFVFHK GSYLRNGWNV MDFVVVLTGI LATAGTDFDL
     RTLRAVRVLR PLKLVSGIPS LQVVLKSIMK AMVPLLQIGL LLFFAIVMFA IIGLEFYMGK
     FHKTCFSNET GEEVGDFPCG EELPARQCES GSTCRKYWQG PNYGITNFDN ILFSVLTVFQ
     CITMEGWTDI LYNTNDAAGN TWNWLYFIPL IIIGSFFMLN LVLGVLSGEF AKERERVENR
     RAFLKLRRQQ QIERELNGYL EWIFKAEEVM LAEEDKNAEE KSPLDVLKRA TIKKSKNDLI
     HAEEGEDHFT DICSVGSPFA RASLKSGKNE SSSYFRRKEK MFRFFIRRMV KAQSFYWIVL
     CVVTLNTLCV AMVHYAQPEK LTTALYFAEF VFLGLFLTEM SLKMYGLGPR NYFHSSFNCF
     DFGVIVGSIF EVIWAAVKPG TSFGISVLRA LRLLRIFKVT KYWNSLRNLV VSLLNSMKSI
     ISLLFLLFLF IVVFALLGMQ LFGGQFNFQD ETPTTNFDTF PAAILTVFQI LTGEDWNAVM
     YHGIESQGGV HSGMFSCVYF IVLTLFGNYT LLNVFLAIAV DNLANAQELT KDEEEMEEAT
     NQKLALQKAK EVAEVSPISA ANISIAAFVK QTRGTVSRSS SVSSVNSPKQ QNSSKSKSVW
     EQRTSQIRIH NFRASCEALY NELDPEERVR YATTLHIRPD MKTHLDRPLV VEPRTEGRNN
     VNKLSPGDVQ DIEQTKAISA ECAEAPRKHH RHRDKDKTGE QEKSDMTKDE NGESGTNNKE
     ERHRQHRSRS KEAEGSSKEG KIERSRGQEA GKRHHRRGSV EEGAEKEHRR HRTHRHSAER
     QGKEGNGTIN GARTERRSRH RGGSRSGNRE GDPGSKGENG EEPHRRHRFR NRALSTYDPV
     EKENGEKEGD VGEKDHRNHQ PKENQCEIEA GASVSVVPVQ TLPSTYLQKV PEQPEDADNQ
     KNVTRMTQPP LDKTTTVNIP VTITAPPGET TVIPMNSVEF ESKTEEKKDV DGDDLTKNGP
     KPILPYSSMF ILSPTNPIRR LFHYIVNLRY FEMVILIVIA LSSIALAAED PVQAESPRND
     ALKYLDYIFT GVFTFEMVIK MIDLGLLLHP GSYFRDLWNI LDFIVVSGAL VAFAFSGTKG
     KDINTIKSLR VLRVLRPLKT IKRLPKLKAV FDCVVNSLKN VLNILIVYML FMFIFAVIAV
     QLFKGRFFYC TDESKELEKD CRGQYLDYEK SEVEAKPRQW KKYEFHYDNV LWALLTLFTV
     STGEGWPTVL KHSVDATYEE QGPSPGYRME MSIFYVVYFV VFPFFFVNIF VALIIITFQE
     QGDKVMSECS LEKNERACID FAISAKPLTR YMPQNKQSFQ YKMWKFVVSP PFEYFIMVMI
     ALNTIVLMMK FYDAPEAYEE MLKCLNIVFT SMFSMECVLK IIAFGVLNYF RDAWNVFDFV
     TVLGSITDIL VTEIADNFIN LSFLRLFRAA RLIKLLRQGY TIRILLWTFV QSFKALPYVC
     LLIAMLFFIY AIIGMQVFGN IALDDDSSIN RHNNFRTFLQ ALMLLFRSAT GEGWHEIMLS
     CLSNRACDPR SGLTKDECGS DFAYFYFVSF IFLCSFLMLN LFVAVIMDNF EYLTRDSSIL
     GPHHLDEFVR VWAEYDPAAC GRISYTDMYE MLRHMSPPLG LGKKCPARVA YKRLVRMNMP
     ISDQDLTVHF TSTLMALIRT ALEIKLASGG VKQHQCDAEL RKEISLVWPN LSQKTLDLLV
     PPHKPDEMTV GKVYAALMIF DFYKQNKNSR EQVHQPPGGL CQTGPVSLFH PLKATLEQTQ
     PPAFNNAKAF LRQKSSASLN NGGTLPAPEG GIKESSSWGI QRTQDIFYET RTPAFERGHS
     EEIPIERTSK QVVEMREISP TLANGEHQPG LESQGRAASM PRLAAETQRS KARSPGSYLA
     PIPDTSPMKR SISTLTPQRP HPMHLYNYSL ERMPPDQVHH HHHHRCHRRK EKKQKSMDRP
     SYHLADGDAV AQPGETSSRD KKQERGRSQE RKQHSSSSSE KQRFYSCDRY GSRDHSQPKS
     AEHSRPTSPN GGPEQGPHRQ GSGSVNGSPL MSTSGASTPC RGRRQLPQTP LTPRPSITYK
     TANSSPVHFT SFQTGLPTFS PGRLSRGLSE HNALLRGDSQ NHSHTMVARI GSDPYLGHRD
     DSDSPYRVVP EDTLTFEEAV ATNSGRSSRT SYVSSLTSQS HQIRRVPNGY HYTLGLNTGP
     GTGSRGRSYY HEADEDDWC
//
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