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Database: UniProt
Entry: A0A151MF56_ALLMI
LinkDB: A0A151MF56_ALLMI
Original site: A0A151MF56_ALLMI 
ID   A0A151MF56_ALLMI        Unreviewed;      2363 AA.
AC   A0A151MF56;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   25-OCT-2017, entry version 11.
DE   RecName: Full=Voltage-dependent N-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   ORFNames=Y1Q_0005596 {ECO:0000313|EMBL:KYO23157.1};
OS   Alligator mississippiensis (American alligator).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC   Alligator.
OX   NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO23157.1};
RN   [1] {ECO:0000313|EMBL:KYO23157.1, ECO:0000313|Proteomes:UP000050525}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO23157.1};
RX   PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA   St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y.,
RA   Gongora J., Dalzell P., Moran C., Bed'hom B., Abzhanov A.,
RA   Burgess S.C., Cooksey A.M., Castoe T.A., Crawford N.G., Densmore L.D.,
RA   Drew J.C., Edwards S.V., Faircloth B.C., Fujita M.K., Greenwold M.J.,
RA   Hoffmann F.G., Howard J.M., Iguchi T., Janes D.E., Khan S.Y.,
RA   Kohno S., de Koning A.J., Lance S.L., McCarthy F.M., McCormack J.E.,
RA   Merchant M.E., Peterson D.G., Pollock D.D., Pourmand N., Raney B.J.,
RA   Roessler K.A., Sanford J.R., Sawyer R.H., Schmidt C.J., Triplett E.W.,
RA   Tuberville T.D., Venegas-Anaya M., Howard J.T., Jarvis E.D.,
RA   Guillette L.J.Jr., Glenn T.C., Green R.E., Ray D.A.;
RT   "Sequencing three crocodilian genomes to illuminate the evolution of
RT   archosaurs and amniotes.";
RL   Genome Biol. 13:415-415(2012).
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1B
CC       gives rise to N-type calcium currents. N-type calcium channels
CC       belong to the 'high-voltage activated' (HVA) group and are blocked
CC       by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin-
CC       IIIA (omega-Aga-IIIA). They are however insensitive to
CC       dihydropyridines (DHP), and omega-agatoxin-IVA (omega-Aga-IVA).
CC       Calcium channels containing alpha-1B subunit may play a role in
CC       directed migration of immature neurons.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KYO23157.1}.
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DR   EMBL; AKHW03006215; KYO23157.1; -; Genomic_DNA.
DR   Proteomes; UP000050525; Unassembled WGS sequence.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005447; VDCC_N_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF161; PTHR10037:SF161; 1.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01631; NVDCCALPHA1.
DR   SMART; SM01062; Ca_chan_IQ; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000050525};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM     89    106       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    127    148       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    160    180       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    215    237       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    291    312       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    324    346       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    500    520       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    526    543       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    625    647       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    703    725       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1172   1191       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1211   1232       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1244   1262       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1305   1327       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1417   1442       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1498   1516       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1528   1551       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1620   1647       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1707   1731       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1747   1782       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      734    761       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2363 AA;  267698 MW;  E667B9B9F073710C CRC64;
     MARFGEELPS RYGGGGPAAA GRGSSRQGGP QPGQRVYKQS MAQRARTMAL YNPIPVKQNC
     FTVNRSLFIF SEDNIIRKYA KRITEWPPFE YMILATIIAN CIVLALEQHL PDGDKTPMSE
     RLDDTEPYFI GIFCFEAGIK IIALGFVFHK GSYLRNGWNV MDFVVVLTGI LATAGTDFDL
     RTLRAVRVLR PLKLVSGIPS LQVVLKSIMK AMVPLLQIGL LLFFAIVMFA IIGLEFYMGK
     FHKTCFSNET GEEVGDFPCG EELPARQCES GSTCRKYWQG PNYGITNFDN ILFSVLTVFQ
     CITMEGWTDI LYNTNDAAGN TWNWLYFIPL IIIGSFFMLN LVLGVLSGEF AKERERVENR
     RAFLKLRRQQ QIERELNGYL EWIFKAEEVM LAEEDKNAEE KSPLDGRAAS EGPIQPGTAP
     AETSGGSSYN MLKRATIKKS KNDLIHAEEG EDHFTDICSV GSPFARASLK SGKNESSSYF
     RRKEKMFRFF IRRMVKAQSF YWIVLCVVTL NTLCVAMVHY AQPEKLTTAL YFAEFVFLGL
     FLTEMSLKMY GLGPRNYFHS SFNCFDFGVI VGSIFEVIWA AVKPGTSFGI SVLRALRLLR
     IFKVTKYWNS LRNLVVSLLN SMKSIISLLF LLFLFIVVFA LLGMQLFGGQ FNFQDETPTT
     NFDTFPAAIL TVFQILTGED WNAVMYHGIE SQGGVHSGMF SCVYFIVLTL FGNYTLLNVF
     LAIAVDNLAN AQELTKDEEE MEEATNQKLA LQKAKEVAEV SPISAANISI AAKQQNSSKS
     KSVWEQRTSQ IRIHNFRASC EALYNELDPE ERVRYATTLH IRPDMKTHLD RPLVVEPRTE
     GRNNVNKLSP GDVQDIEQTK AISAECAEAP RKHHRHRDKD KTGEQEKSDM TKDENGESGT
     NNKEERHRQH RSRSKEAEGS SKEGKIERSR GQEAGKRHHR RGSVEEGAEK EHRRHRTHRH
     SAERQGKEGN GTINGARTER RSRHRGGSRS GNREGDPGSK GENGEEPHRR HRFRNRALST
     YDPVEKENGE KEGDVGEKDH RNHQPKENQC EIEAGASVSV VPVQTLPSTY LQKVPEQPED
     ADNQKNVTRM TQPPLDKTTT VNIPVTITAP PGETTVIPMN SVEFESKTEE KKDVDGDDLT
     KNGPKPILPY SSMFILSPTN PIRRLFHYIV NLRYFEMVIL IVIALSSIAL AAEDPVQAES
     PRNDALKYLD YIFTGVFTFE MVIKMIDLGL LLHPGSYFRD LWNILDFIVV SGALVAFAFS
     GTKGKDINTI KSLRVLRVLR PLKTIKRLPK LKAVFDCVVN SLKNVLNILI VYMLFMFIFA
     VIAVQLFKGR FFYCTDESKE LEKDCRGQYL DYEKSEVEAK PRQWKKYEFH YDNVLWALLT
     LFTVSTGEGW PTVLKHSVDA TYEEQGPSPG YRMEMSIFYV VYFVVFPFFF VNIFVALIII
     TFQEQGDKVM SECSLEKNER ACIDFAISAK PLTRYMPQNK QSFQYKMWKF VVSPPFEYFI
     MVMIALNTIV LMMKFYDAPE AYEEMLKCLN IVFTSMFSME CVLKIIAFGV LNYFRDAWNV
     FDFVTVLGSI TDILVTEIAD NFINLSFLRL FRAARLIKLL RQGYTIRILL WTFVQSFKAL
     PYVCLLIAML FFIYAIIGMQ VFGNIALDDD SSINRHNNFR TFLQALMLLF RSATGEGWHE
     IMLSCLSNRA CDPRSGLTKD ECGSDFAYFY FVSFIFLCSF LMLNLFVAVI MDNFEYLTRD
     SSILGPHHLD EFVRVWAEYD PAACGRISYT DMYEMLRHMS PPLGLGKKCP ARVAYKRLVR
     MNMPISDQDL TVHFTSTLMA LIRTALEIKL ASGGVKQHQC DAELRKEISL VWPNLSQKTL
     DLLVPPHKPD EMTVGKVYAA LMIFDFYKQN KNSREQVHQP PGGLCQTGPV SLFHPLKATL
     EQTQPPAFNN AKAFLRQKSS ASLNNGGTLP APEGGIKESS SWGIQRTQDI FYETRTPAFE
     RGHSEEIPIE RTSKQVVEMR EISPTLANGE HQPGLESQGR AASMPRLAAE TQRSKARSPG
     SYLAPIPDTS PMKRSISTLT PQRPHPMHLY NYSLERMPPD QVHHHHHHRC HRRKEKKQKS
     MDRPSYHLAD GDAVAQPGET SSRDKKQERG RSQERKQHSS SSSEKQRFYS CDRYGSRDHS
     QPKSAEHSRP TSPNGGPEQG PHRQGSGSVN GSPLMSTSGA STPCRGRRQL PQTPLTPRPS
     ITYKTANSSP VHFTSFQTGL PTFSPGRLSR GLSEHNALLR GDSQNHSHTM VARIGSDPYL
     GHRDDSDSPY RVVPEDTLTF EEAVATNSGR SSRTSYVSSL TSQSHQIRRV PNGYHYTLGL
     NTGPGTGSRG RSYYHEADED DWC
//
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