ID A0A151MG43_ALLMI Unreviewed; 1508 AA.
AC A0A151MG43;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=Crumbs-like protein 2 isoform A {ECO:0000313|EMBL:KYO23478.1};
GN Name=CRB2 {ECO:0000313|EMBL:KYO23478.1};
GN ORFNames=Y1Q_0005831 {ECO:0000313|EMBL:KYO23478.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO23478.1};
RN [1] {ECO:0000313|EMBL:KYO23478.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO23478.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO23478.1}.
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DR EMBL; AKHW03006215; KYO23478.1; -; Genomic_DNA.
DR STRING; 8496.A0A151MG43; -.
DR eggNOG; KOG1217; Eukaryota.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 18.
DR CDD; cd00110; LamG; 3.
DR Gene3D; 2.60.120.200; -; 3.
DR Gene3D; 2.10.25.10; Laminin; 19.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR001791; Laminin_G.
DR PANTHER; PTHR24049; CRUMBS FAMILY MEMBER; 1.
DR PANTHER; PTHR24049:SF19; PROTEIN CRUMBS HOMOLOG 2; 1.
DR Pfam; PF00008; EGF; 14.
DR Pfam; PF12661; hEGF; 2.
DR Pfam; PF02210; Laminin_G_2; 3.
DR PRINTS; PR00010; EGFBLOOD.
DR SMART; SM00181; EGF; 19.
DR SMART; SM00179; EGF_CA; 18.
DR SMART; SM00282; LamG; 3.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 3.
DR SUPFAM; SSF57196; EGF/Laminin; 13.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 13.
DR PROSITE; PS00022; EGF_1; 15.
DR PROSITE; PS01186; EGF_2; 12.
DR PROSITE; PS50026; EGF_3; 19.
DR PROSITE; PS01187; EGF_CA; 6.
DR PROSITE; PS50025; LAM_G_DOMAIN; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1448..1469
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 96..135
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 137..175
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 177..214
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 216..252
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 254..290
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 292..328
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 330..366
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 368..405
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 407..443
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 445..501
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 503..539
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 541..582
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 601..780
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 782..818
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 824..1000
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 1002..1038
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1064..1239
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 1241..1277
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1279..1314
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1316..1352
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1356..1393
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1395..1431
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 146..163
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 165..174
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 204..213
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 242..251
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 280..289
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 318..327
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 356..365
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 433..442
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 491..500
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 529..538
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 808..817
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1028..1037
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1267..1276
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1283..1293
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1304..1313
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1342..1351
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1383..1392
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1421..1430
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1508 AA; 162357 MW; A9363B230776EBEB CRC64;
MQMYRVPGVP SALAGSEARK VFLKIVRELE GCHNLDYEIS GRNHIFLQNA RSLMHGLLYY
CSSAIQDLRA GTKMAYHAAA LLPVFLLLWG STCAEDVKSC SSSPCQNGGS CEDLGRGYRC
VCPQQPLAYT GTNCELLYDA CAVHACPTNK TCRTVPGLQE YDCICRPGFT GIDCSVNINE
CESNPCKEPH FECVDSVNGY TCQCQTGLTG EGCQTAISLC SSHACLNNGT CVQSAEDYVC
FCPPGFTGDH CEHDVNECAS SPCQNGAICR DMVNEYKCFC VPGFQGYRCE IDINECASRP
CKNNGTCRNE RDHYICECVP GYTDVNCDAE INECDSDPCE NGGTCSDHIG FFTCSCAPGY
EGVQCEVDIN ECLSQPCNNG GKCLDLVNSY QCDCSDTGFE GEHCELDILE CASQPCLNSA
TCLEGVKNYS CACWPGYMGQ RCEEDVDECA TEPCHNGGVC FERSNQSYYG TQPDFPHEFS
YSQAAGFLCW CQPGFEGETC SINIDECESQ PCQHGARCED LVNGFLCHCP PGYSGVECAV
DINECEDGPC EHGAACEDGI ADYTCRCVPS QNGTVWGGKN CSIQLTGCQT HDCQNEALCT
PTTFLPIDMS TGDWSRKDGA GVAVASVSLR FRTTLPDAIL FYRGQEEAYL FLELSGGTLH
AGVQRNNSKS SLALAGLKVD DGQWHKAEVL LQDSVELKLW HESCDAGVCL QSAVVGDSAT
LLPPAFLKAY VGGVDGSGIA NTTRSRQGYI GCLQDLQVDS QAVLPLDLLP NASSLAALGC
DRTEWCQAQP CSHGGSCVDL WATFRCNCSR PYEGLTCSYE YPAATFGLED SSSFASFTLA
DNPMANFSVS FFIRTLKPEG LVLQVHDGTG PCLTVYLKDG RLLLETPSAG PMAFSEVLAD
GKRHLVTLSF REGVAYISHS DREVELGHLG VRPLAVGHEV YVGGLPQQES MGTWGGYFKG
CLQDIQLNNH RLELFAHQAD NYSLPRVAYV GRTTGLVQGC ISDDTCKSKP CHNGGVCTVT
WNDFSCSCPA NFTGKTCEER VWCESAPCPK ATACVDVPAG YVCLANATFY GHAATEFTTN
ASVTRTLSSV RLDFRTRDAD AILLRATEAV GSLQIAIQNS SLLVEMSSGN SIEGASFRSR
MPVTDGAWHT VSLTMEEPSA LSSRWLVHLD SSMNATLQGR AGDLAFLRTN ALIVLAENFT
GCLGEVTIGE IHLPFTAHLP YPQPEQFLQA GGSAIQLGCM GADVCGSSPC LNAGTCEDLF
DSFRCACSAG WAGPLCEANI DDCQASPCVH GTCVDLVADF QCECAPGFVG KKCDVDVDDC
GQHQCLHSGT CVDEVAGYSC KCLPEYSGPR CEWPFPPEQC GKNFTCLNGG KCTSGPWGAN
CTCKPGFTGR NCQININECD PNPCQNGGTC QDAVNKYECV CSASYTGERC DIDKGTPGAF
FPFPLLEVAV PVACGCLLLV IIGLIFMILT ARKRRQSEGT YSPSQQEVAG ARLEMDSVLK
VPPEERLI
//