GenomeNet

Database: UniProt
Entry: A0A151MIB9_ALLMI
LinkDB: A0A151MIB9_ALLMI
Original site: A0A151MIB9_ALLMI 
ID   A0A151MIB9_ALLMI        Unreviewed;      2286 AA.
AC   A0A151MIB9;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   25-OCT-2017, entry version 11.
DE   RecName: Full=Voltage-dependent R-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   ORFNames=Y1Q_0004297 {ECO:0000313|EMBL:KYO24256.1};
OS   Alligator mississippiensis (American alligator).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC   Alligator.
OX   NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO24256.1};
RN   [1] {ECO:0000313|EMBL:KYO24256.1, ECO:0000313|Proteomes:UP000050525}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO24256.1};
RX   PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA   St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y.,
RA   Gongora J., Dalzell P., Moran C., Bed'hom B., Abzhanov A.,
RA   Burgess S.C., Cooksey A.M., Castoe T.A., Crawford N.G., Densmore L.D.,
RA   Drew J.C., Edwards S.V., Faircloth B.C., Fujita M.K., Greenwold M.J.,
RA   Hoffmann F.G., Howard J.M., Iguchi T., Janes D.E., Khan S.Y.,
RA   Kohno S., de Koning A.J., Lance S.L., McCarthy F.M., McCormack J.E.,
RA   Merchant M.E., Peterson D.G., Pollock D.D., Pourmand N., Raney B.J.,
RA   Roessler K.A., Sanford J.R., Sawyer R.H., Schmidt C.J., Triplett E.W.,
RA   Tuberville T.D., Venegas-Anaya M., Howard J.T., Jarvis E.D.,
RA   Guillette L.J.Jr., Glenn T.C., Green R.E., Ray D.A.;
RT   "Sequencing three crocodilian genomes to illuminate the evolution of
RT   archosaurs and amniotes.";
RL   Genome Biol. 13:415-415(2012).
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1E
CC       gives rise to R-type calcium currents. R-type calcium channels
CC       belong to the 'high-voltage activated' (HVA) group and are blocked
CC       by nickel, and partially by omega-agatoxin-IIIA (omega-Aga-IIIA).
CC       They are however insensitive to dihydropyridines (DHP), omega-
CC       conotoxin-GVIA (omega-CTx-GVIA), and omega-agatoxin-IVA (omega-
CC       Aga-IVA). Calcium channels containing alpha-1E subunit could be
CC       involved in the modulation of firing patterns of neurons which is
CC       important for information processing.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KYO24256.1}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AKHW03006099; KYO24256.1; -; Genomic_DNA.
DR   Proteomes; UP000050525; Unassembled WGS sequence.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005449; VDCC_R_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF57; PTHR10037:SF57; 1.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01633; RVDCCALPHA1.
DR   SMART; SM01062; Ca_chan_IQ; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000050525};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM     93    110       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    130    150       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    162    180       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    221    240       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    295    316       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    328    350       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    477    496       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    502    521       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    603    625       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    681    703       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1132   1150       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1202   1219       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1263   1285       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1375   1400       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1456   1474       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1486   1509       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1515   1533       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1580   1598       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1673   1697       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1713   1748       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      699    726       {ECO:0000256|SAM:Coils}.
FT   COILED     1076   1098       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2286 AA;  259120 MW;  E84E6A8AC67E265F CRC64;
     MARFGEAVAG RLGSADGGSE QSRSRPGAAA PAGGTPGAFK QTKAQRARTM ALYNPIPVRQ
     NCFTVNRSLF LFGEDNVVRK YAKKLIDWPP FEYMILATII ANCIVLALEQ HLPGDDKTPM
     SRRLEKTEPY FIGIFCFEAG IKIVALGFVF HKGSYLRNGW NVMDFIVVLS GILATAGTHF
     NTHVDLRTLR AVRVLRPLKL VSGIPSLQIV LKSIMKAMVP LLQIGLLLFF AILMFAIIGL
     EFYSGKLHRA CYANNSGELE ELDPPHPCGV QGCPPGYECK EWIGPNDGIT QFDNILFAVL
     TVFQCITMEG WTTVLYNTND ALGATWNWLY FIPLIIIGSF FVLNLVLGVL SGEFAKERER
     VENRRAFMKL RRQQQIEREL NGYRAWIDKA EEVMLAEENK NAGTSALEVL RRATIKRNRT
     EAMNRDSSDE HCVDISSVGT PLARSSIKSA KVDGASYFRH KERLLRISVR HMVKSQVFYW
     IVLSLVALNT ACVAIVHHNQ PLWLTHLLYY AEFLFLGLFL LEMSLKMYGM GPRLYFHSSF
     NCFDCGVTVG SIFEVVWAIF RPGTSFGISV LRALRLLRIF KITKYWASLR NLVVSLMSSM
     KSIISLLFLL FLFIVVFALL GMQLFGGRFN FMDGTPSANF DTFPAAIMTV FQILTGEDWN
     EVMYNGIRSQ GGVRSGMWSS IYFIILTLFG NYTLLNVFLA IAVDNLANAQ ELTKDEQEEE
     EAFNQKHALQ KAKEVSPMSA PNMPTVERDR RRRHHMSMWE PRSSQLRERR RRHHMSVWEQ
     RTSQLRRHMQ MSSQEGINKD EPPLLNPHAS IFRRKKPGEN VASDKPEEEQ GGKAEQPQVE
     GLEQPTTGTN VSASEDKRSP SPRAKRERDQ WHQKSCHGNC DPTEQDGSGG GGSGFEDRAR
     LRQSQRRSRH RRVRTEGKEP AGALESRSTS QDTGLEDANP AEGQQKRNEG GKEENLIQGE
     QAGEELKRTN GIPANEAEVP GATKDRSPPK VPHELNQGNN VSLTEQDCSS LDTSDQALLG
     GLQMEMSRAI SRSEPDLSSI TANTEKATES TTIMIDVQDS TVVQISNKTD GEASPLKEAE
     TKEDEEEAEK KKRKKEKSSE TGKAMVPHSS MFIFSTTNPV RRACHYIVNL RYFEMCILLV
     IAASSIALAA EDPVLTNSDR NKVLRYFDYV FTGVFTFEMV IKMIDQGLIL QDGSYFRDLW
     NILDFIVVVG ALVAFALATN KGRDIKTIKS LRVLRVLRPL KTIKRLPKLK AVFDCVVTSL
     KNVFNILIVY KLFMFIFAVI AVQLFKGKFF YCTDSSKDTE KDCIGNYVDH EKNKMEVKCR
     EWKRHEFHYD NIIWALLTLF TVSTGEGWPQ VLQHSVDVTE EDRGPSRSNR MEMSIFYVVY
     FVVFPFFFVN IFVALIIITF QEQGDKMMEE CSLEKNERAC IDFAISAKPL TRYMPQNRHT
     FQYRVWHFVV SPSFEYTIMA MIALNTVVLM MKYYSAPYTY ELALKYLNIA FTMVFSLECV
     LKIIAFGFLN YFRDTWNIFD FITVIGSITE IILTDTKLVN TSGFNMSFLK LFRAARLIKL
     LRQGYTIRIL LWTFVQSFKA LPYVCLLIAM LFFIYAIIGM QVFGNIKLDE GSHINRHNNF
     RSFLASLMLL FRSATGEAWQ EIMLSCLEGK GCEPDTTATS GQNENERCGT DLAYVYFVSF
     IFFCSFLMLN LFVAVIMDNF EYLTRDSSIL GPHHLDEFVR IWAEYDRAAC GRIHYTEMYE
     MLTLMSPPLG LGKRCPSKVA YKRLVLMNMP VAEDMTVHFT STLMALIRTA LDIKIAKGGA
     DWQQLDSELQ KEILTIWPHL SQKMLDLLVP MPKTSDLTVG KIYAAMMIMD YYKQSKAKKQ
     RQQLEEQKNA PMFQRMEPSS LPQEIISNAK ALPYLQQDTL SGLSSRSGFP SLSPLSPQEI
     FQLACMDPTH GQYQEHQSLE PEVREFKRVQ PSNRGNYLPV DTQERAVSGR ASSMPRLTVD
     PQVVTDTSSM RRSFSTIRDK RTNSSWLDEF SMERSSENTY KSRRRSYHSS LQLTARRLNA
     DSGHRSDTHR SGGRERGRSK ERKHLLSPDI SRCNSEERSP QADCESPERR RQSRSPSEGR
     SQTPNRQGTG SLSESSIPSI SDTSTPRRGR RQLPPVPPKP RPFISYTSMM QHAGDTSPQP
     DESEGGSPLL SKALETNDTC LTESSSSPQG KQSRHSTPQR YISEPYLALH DDSHASDCGE
     EETLTFEAAV ATSLGRSNTI GSAPPMRHSW QMPNGHYRRR RRGAAQGVMC GASIDVLSDT
     EEDDKC
//
DBGET integrated database retrieval system