ID A0A151MIF6_ALLMI Unreviewed; 1313 AA.
AC A0A151MIF6;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE SubName: Full=Tenascin-N isoform B {ECO:0000313|EMBL:KYO24321.1};
GN Name=TNW {ECO:0000313|EMBL:KYO24321.1};
GN ORFNames=Y1Q_0004345 {ECO:0000313|EMBL:KYO24321.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO24321.1};
RN [1] {ECO:0000313|EMBL:KYO24321.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO24321.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- SIMILARITY: Belongs to the tenascin family.
CC {ECO:0000256|ARBA:ARBA00008673}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO24321.1}.
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DR EMBL; AKHW03006099; KYO24321.1; -; Genomic_DNA.
DR eggNOG; KOG1225; Eukaryota.
DR eggNOG; KOG2579; Eukaryota.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProt.
DR CDD; cd00055; EGF_Lam; 1.
DR CDD; cd00063; FN3; 10.
DR CDD; cd00087; FReD; 1.
DR Gene3D; 3.90.215.10; Gamma Fibrinogen, chain A, domain 1; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 10.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR041161; EGF_Tenascin.
DR InterPro; IPR036056; Fibrinogen-like_C.
DR InterPro; IPR014716; Fibrinogen_a/b/g_C_1.
DR InterPro; IPR002181; Fibrinogen_a/b/g_C_dom.
DR InterPro; IPR020837; Fibrinogen_CS.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR002049; LE_dom.
DR NCBIfam; NF040941; GGGWT_bact; 1.
DR PANTHER; PTHR46708; TENASCIN; 1.
DR PANTHER; PTHR46708:SF5; TENASCIN N; 1.
DR Pfam; PF18720; EGF_Tenascin; 2.
DR Pfam; PF00147; Fibrinogen_C; 1.
DR Pfam; PF00041; fn3; 10.
DR SMART; SM00181; EGF; 3.
DR SMART; SM00186; FBG; 1.
DR SMART; SM00060; FN3; 10.
DR SUPFAM; SSF56496; Fibrinogen C-terminal domain-like; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 6.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS00514; FIBRINOGEN_C_1; 1.
DR PROSITE; PS51406; FIBRINOGEN_C_2; 1.
DR PROSITE; PS50853; FN3; 6.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022530}.
FT DOMAIN 191..279
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 280..373
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 460..549
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 636..725
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 811..900
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 987..1080
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1073..1290
FT /note="Fibrinogen C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51406"
FT REGION 1288..1313
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1313 AA; 146624 MW; 40047ED921C1CFAA CRC64;
MGEAEEGEEQ NIIFRHNIRV LTPKGDCEAL DHLRALLERM EKLEKEVMEL REACNPQKCC
GGGQGISDCS SHGTFIQEIC SCNCDEGWEG SNCSRPSCPN SCSGNGRCVD GKCICHEPYV
GEDCSQRLCP ENCSGNGICN NGVCQCYEEF IGDDCSEKRC PNDCNGNGFC DTGECYCHDG
FVGLDCSQVL TPQNLQLLKT TEGSLTLSWD EVIDVDYYLI SYYPMGYQTS VKQVRVPKGQ
LSYEIVGLHP STTYNITLRH VKKGISSDPE NLQASTALSV VGAIWVTDET EDSLEVEWEN
PPAEVDYYKL RFRSLPGQGE EEVMVPKSSE PKSRYIITGL KPGTVYNITV IYMKDNIEGK
PSSVTGRTGI DGPTNLVTDR VTEDTATISW KGVQAPIDRY MVTYTTADGD SKEVAVRKDK
SMTTLTGLRP GMEYIIYIWA EKGAHQSKRT STKAVTEMDG PTNLVTDQVT EDTATISWKG
VWAPIDRYMV SYTSPDGDAR ELPVGQDRSV HTLTGLRPGV EYTIYIWAEK GTQQSKSTNT
TAVTEIDSPT NLVTDQVTED TATISWRAVQ APIDRYMVSY TSPDGDSREM AVENDRSITT
LMGLRPGMEY IIYIWAEKGT QQSKRADTKA LTEIDSPTNL VTDQVTEDTA TISWKQVQAP
IDRYMVSYAS PDGDKREMAV WKDKSITTLT GLRPGVEYII YIWAEKGTQQ SKREDTRAVT
EIDSPTNLVA DRVTENTATI SWMGVQAPID RYMVSYTSLD GDTREMAAGK DRSITLTGLR
PGMEYIIYIW AEKGTQQSKR ASTEVLTEID GPTNLVTDQV TEDTATILWK QVQAPIDRYM
VSYTSPDGDT REMAVGKDRS ITTLTGLKPG VEYIIYIWAE KGTQQSKRAD TRAVTEIDSP
INLVTDRVTE DTATISWQGV QAPIDRYIVR YTLPDGDAKE MAVGKDKSVT TLTGLTPGME
YIIYIWAEKG AQQSKKANTK ALTEIDPPKN LRVSDVTQST SIVNWTPPTA QIDGYTLTYQ
GVDGTSKEVQ LGPDDQRFML EGLGKGVRYT VYVLAFKGDR RSRKASSSFS TIGFLYPYPA
DCSQMQQNGN ATSGMYTIYL NSDASRPMEV YCDMTTDGGG WIVFQRRNTG ELDFYKRWRN
YVEGFGDPMG EFWLGLDKLH SLTSATPIRY EIRVDLRTSN ESAYAVYDFF QVASSRDRYK
LSVGNYRGTA GDALTYHNGW KFTTWDRDND VALSNCALAH RGAWWYKNCH LANLNGKYGE
TKHSEGVNWE PWKGHEFSIP FTEMKIRPQS SSNEPILGRK KRSLAGKRKK TRV
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